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Volumn 37, Issue 1, 2016, Pages 61-69

The role of astrocytes in the progression of brain cancer: complicating the picture of the tumor microenvironment

Author keywords

Astrocytes; Glioma; Invasion; Proliferation; Reactive gliosis

Indexed keywords

GELATINASE A; INTERLEUKIN 10; INTERLEUKIN 6; MATRIX METALLOPROTEINASE 14; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; GLIAL FIBRILLARY ACIDIC PROTEIN;

EID: 84944909152     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4242-0     Document Type: Review
Times cited : (91)

References (51)
  • 1
    • 84964267278 scopus 로고    scopus 로고
    • Median cancer survival times. Macmillan Cancer Support. 2011
    • Median cancer survival times. Macmillan Cancer Support. 2011.
  • 2
    • 84964267280 scopus 로고    scopus 로고
    • Glioblastoma and malignant astrocytoma. American Brain Tumor Association. 2014
    • Glioblastoma and malignant astrocytoma. American Brain Tumor Association. 2014.
  • 4
    • 84887586764 scopus 로고    scopus 로고
    • Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology
    • PID: 2407032
    • Chaichana KL, Gadkaree S, Rao K, Link T, Rigamonti D, Purtell M, et al. Patients undergoing surgery of intracranial metastases have different outcomes based on their primary pathology. Neurol Res. 2013;35:1059–69.
    • (2013) Neurol Res , vol.35 , pp. 1059-1069
    • Chaichana, K.L.1    Gadkaree, S.2    Rao, K.3    Link, T.4    Rigamonti, D.5    Purtell, M.6
  • 6
    • 84875954974 scopus 로고    scopus 로고
    • The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches
    • PID: 2359639
    • O’Brien ER, Howarth C, Sibson NR. The role of astrocytes in CNS tumors: pre-clinical models and novel imaging approaches. Front Cell Neurosci. 2013;7:40.
    • (2013) Front Cell Neurosci , vol.7 , pp. 40
    • O’Brien, E.R.1    Howarth, C.2    Sibson, N.R.3
  • 7
    • 84889095438 scopus 로고    scopus 로고
    • Review: molecular mechanism of microglia stimulated glioblastoma invasion
    • COI: 1:CAS:528:DC%2BC3sXhvFOhs77F, PID: 2393317
    • Coniglio SJ, Segall JE. Review: molecular mechanism of microglia stimulated glioblastoma invasion. Matrix Biol. 2013;32:372–80.
    • (2013) Matrix Biol , vol.32 , pp. 372-380
    • Coniglio, S.J.1    Segall, J.E.2
  • 8
    • 84864709456 scopus 로고    scopus 로고
    • Li W, Graeber MB. The molecular profile of microglia under the influence of glioma. Neuro-oncology. 2012:nos116
    • Li W, Graeber MB. The molecular profile of microglia under the influence of glioma. Neuro-oncology. 2012:nos116.
  • 10
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: cellular and molecular cues to biological function
    • COI: 1:CAS:528:DyaK2sXnvFWnt7c%3D, PID: 941667
    • Ridet J, Privat A, Malhotra S, Gage F. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997;20:570–7.
    • (1997) Trends Neurosci , vol.20 , pp. 570-577
    • Ridet, J.1    Privat, A.2    Malhotra, S.3    Gage, F.4
  • 11
    • 84860322835 scopus 로고    scopus 로고
    • Genomic analysis of reactive astrogliosis
    • COI: 1:CAS:528:DC%2BC38XmvFehs70%3D, PID: 2255304
    • Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, et al. Genomic analysis of reactive astrogliosis. J Neurosci. 2012;32:6391–410.
    • (2012) J Neurosci , vol.32 , pp. 6391-6410
    • Zamanian, J.L.1    Xu, L.2    Foo, L.C.3    Nouri, N.4    Zhou, L.5    Giffard, R.G.6
  • 12
    • 77951735629 scopus 로고    scopus 로고
    • IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1
    • COI: 1:CAS:528:DC%2BC3cXmvFyqsbY%3D, PID: 2042880
    • Li R, Li G, Deng L, Liu Q, Dai J, Shen J, et al. IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1. Oncol Rep. 2010;23:1553–9.
    • (2010) Oncol Rep , vol.23 , pp. 1553-1559
    • Li, R.1    Li, G.2    Deng, L.3    Liu, Q.4    Dai, J.5    Shen, J.6
  • 13
    • 0034703250 scopus 로고    scopus 로고
    • Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system
    • COI: 1:CAS:528:DC%2BD3cXmslyis70%3D, PID: 1100796
    • Rathke-Hartlieb S, Budde P, Ewert S, Schlomann U, Staege MS, Jockusch H, et al. Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system. FEBS Lett. 2000;481:227–34.
    • (2000) FEBS Lett , vol.481 , pp. 227-234
    • Rathke-Hartlieb, S.1    Budde, P.2    Ewert, S.3    Schlomann, U.4    Staege, M.S.5    Jockusch, H.6
  • 14
    • 79951672873 scopus 로고    scopus 로고
    • Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis
    • COI: 1:CAS:528:DC%2BC3cXhsFCru7zI, PID: 2095389
    • Seike T, Fujita K, Yamakawa Y, Kido MA, Takiguchi S, Teramoto N, et al. Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. Clin Exp Metastasis. 2011;28:13–25.
    • (2011) Clin Exp Metastasis , vol.28 , pp. 13-25
    • Seike, T.1    Fujita, K.2    Yamakawa, Y.3    Kido, M.A.4    Takiguchi, S.5    Teramoto, N.6
  • 15
    • 77955100047 scopus 로고    scopus 로고
    • GDF-15 contributes to proliferation and immune escape of malignant gliomas
    • COI: 1:CAS:528:DC%2BC3cXpsVCis7g%3D, PID: 2053473
    • Roth P, Junker M, Tritschler I, Mittelbronn M, Dombrowski Y, Breit SN, et al. GDF-15 contributes to proliferation and immune escape of malignant gliomas. Clin Cancer Res. 2010;16:3851–9.
    • (2010) Clin Cancer Res , vol.16 , pp. 3851-3859
    • Roth, P.1    Junker, M.2    Tritschler, I.3    Mittelbronn, M.4    Dombrowski, Y.5    Breit, S.N.6
  • 17
    • 84872790252 scopus 로고    scopus 로고
    • Astrocytes enhance the invasion potential of glioblastoma stem-like cells
    • COI: 1:CAS:528:DC%2BC3sXhvF2gtbo%3D, PID: 2334996
    • Rath BH, Fair JM, Jamal M, Camphausen K, Tofilon PJ. Astrocytes enhance the invasion potential of glioblastoma stem-like cells. PLoS One. 2013;8, e54752.
    • (2013) PLoS One , vol.8
    • Rath, B.H.1    Fair, J.M.2    Jamal, M.3    Camphausen, K.4    Tofilon, P.J.5
  • 18
    • 84890467312 scopus 로고    scopus 로고
    • Targeting the PDGF signaling pathway in tumor treatment
    • PID: 2435940
    • Heldin C-H. Targeting the PDGF signaling pathway in tumor treatment. Cell Commun Signal. 2013;11:97.
    • (2013) Cell Commun Signal , vol.11 , pp. 97
    • Heldin, C.-H.1
  • 19
    • 84880698423 scopus 로고    scopus 로고
    • Carcinoma cells misuse the host tissue damage response to invade the brain
    • PID: 2383264
    • Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, et al. Carcinoma cells misuse the host tissue damage response to invade the brain. Glia. 2013;61:1331–46.
    • (2013) Glia , vol.61 , pp. 1331-1346
    • Chuang, H.N.1    van Rossum, D.2    Sieger, D.3    Siam, L.4    Klemm, F.5    Bleckmann, A.6
  • 20
    • 84925010154 scopus 로고    scopus 로고
    • Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages toll-like receptor 2 signaling
    • PID: 2545239
    • Hu F, a Dzaye OD, Hahn A, Yu Y, Scavetta RJ, Dittmar G, et al. Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages toll-like receptor 2 signaling. Neuro-Oncology. 2015;17:200–10.
    • (2015) Neuro-Oncology , vol.17 , pp. 200-210
    • Hu, F.1    a Dzaye, O.D.2    Hahn, A.3    Yu, Y.4    Scavetta, R.J.5    Dittmar, G.6
  • 21
    • 0034282497 scopus 로고    scopus 로고
    • Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase
    • COI: 1:CAS:528:DC%2BD3cXmsFWhsrY%3D, PID: 1098728
    • Marchetti D, Li J, Shen R. Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res. 2000;60:4767–70.
    • (2000) Cancer Res , vol.60 , pp. 4767-4770
    • Marchetti, D.1    Li, J.2    Shen, R.3
  • 22
    • 77956416659 scopus 로고    scopus 로고
    • Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression
    • COI: 1:CAS:528:DC%2BC3cXptV2js7w%3D, PID: 2062211
    • Huang J-Y, Cheng Y-J, Lin Y-P, Lin H-C, Su C-C, Juliano R, et al. Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression. J Immunol. 2010;185:1450–9.
    • (2010) J Immunol , vol.185 , pp. 1450-1459
    • Huang, J.-Y.1    Cheng, Y.-J.2    Lin, Y.-P.3    Lin, H.-C.4    Su, C.-C.5    Juliano, R.6
  • 23
    • 84880101415 scopus 로고    scopus 로고
    • Venero JL. A brief overview of multitalented microglia
    • Joseph B, Venero JL. A brief overview of multitalented microglia. Microglia, Springer, 2013, pp 3–8.
    • (2013) Microglia, Springer , pp. 3-8
    • Joseph, B.1
  • 25
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communication elements: the revolution continues
    • COI: 1:CAS:528:DC%2BD2MXmvVGht7Y%3D, PID: 1602509
    • Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci. 2005;6:626–40.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2
  • 28
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • COI: 1:CAS:528:DC%2BD2MXhtlaktbjP, PID: 1637194
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006;7:41–53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 29
    • 34248581586 scopus 로고    scopus 로고
    • The human subventricular zone: a source of new cells and a potential source of brain tumors
    • PID: 1745937
    • Quiñones-Hinojosa A, Chaichana K. The human subventricular zone: a source of new cells and a potential source of brain tumors. Exp Neurol. 2007;205:313–24.
    • (2007) Exp Neurol , vol.205 , pp. 313-324
    • Quiñones-Hinojosa, A.1    Chaichana, K.2
  • 30
    • 53949093698 scopus 로고    scopus 로고
    • Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization
    • PID: 1864911
    • Fitzgerald DP, Palmieri D, Hua E, Hargrave E, Herring JM, Qian Y, et al. Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization. Clin Exp Metastasis. 2008;25:799–810.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 799-810
    • Fitzgerald, D.P.1    Palmieri, D.2    Hua, E.3    Hargrave, E.4    Herring, J.M.5    Qian, Y.6
  • 31
    • 0028351179 scopus 로고
    • Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF‐α, BFGF, il‐2] on glioma spheroid growth, migration and invasion
    • COI: 1:CAS:528:DyaK2cXivFGnsbk%3D, PID: 831430
    • Pedersen PH, Ness GO, Engebraaten O, Bjerkvig R, Lillehaug JR, Laerum OD. Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF‐α, BFGF, il‐2] on glioma spheroid growth, migration and invasion. Int J Cancer. 1994;56:255–61.
    • (1994) Int J Cancer , vol.56 , pp. 255-261
    • Pedersen, P.H.1    Ness, G.O.2    Engebraaten, O.3    Bjerkvig, R.4    Lillehaug, J.R.5    Laerum, O.D.6
  • 33
    • 84927689875 scopus 로고    scopus 로고
    • Astrocytes facilitate melanoma brain metastasis via secretion of IL‐23
    • COI: 1:CAS:528:DC%2BC2MXms1Wjsbs%3D, PID: 2563923
    • Klein A, Schwartz H, Sagi‐Assif O, Meshel T, Izraely S, Menachem SB, et al. Astrocytes facilitate melanoma brain metastasis via secretion of IL‐23. J Pathol. 2015;236(1):116–27.
    • (2015) J Pathol , vol.236 , Issue.1 , pp. 116-127
    • Klein, A.1    Schwartz, H.2    Sagi‐Assif, O.3    Meshel, T.4    Izraely, S.5    Menachem, S.B.6
  • 34
    • 0038719646 scopus 로고    scopus 로고
    • Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator–plasmin cascade
    • PID: 1276409
    • Le DM, Besson A, Fogg DK, Choi K-S, Waisman DM, Goodyer CG, et al. Exploitation of astrocytes by glioma cells to facilitate invasiveness: a mechanism involving matrix metalloproteinase-2 and the urokinase-type plasminogen activator–plasmin cascade. J Neurosci. 2003;23:4034–43.
    • (2003) J Neurosci , vol.23 , pp. 4034-4043
    • Le, D.M.1    Besson, A.2    Fogg, D.K.3    Choi, K.-S.4    Waisman, D.M.5    Goodyer, C.G.6
  • 35
    • 79952371255 scopus 로고    scopus 로고
    • Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
    • COI: 1:CAS:528:DC%2BC3MXjt1Kht7k%3D, PID: 2139019
    • Kim S-J, Kim J-S, Park ES, Lee J-S, Lin Q, Langley RR, et al. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia. 2011;13:286–98.
    • (2011) Neoplasia , vol.13 , pp. 286-298
    • Kim, S.-J.1    Kim, J.-S.2    Park, E.S.3    Lee, J.-S.4    Lin, Q.5    Langley, R.R.6
  • 36
    • 84961290723 scopus 로고    scopus 로고
    • Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes
    • Chen W, Wang D, Du X, He Y, Chen S, Shao Q, et al. Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes. Med Oncol. 2015;32:1–13.
    • (2015) Med Oncol , vol.32 , pp. 1-13
    • Chen, W.1    Wang, D.2    Du, X.3    He, Y.4    Chen, S.5    Shao, Q.6
  • 37
    • 77956855574 scopus 로고    scopus 로고
    • Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels
    • COI: 1:CAS:528:DC%2BC3cXhtFGmtrfE, PID: 2082405
    • Lin Q, Balasubramanian K, Fan D, Kim S-J, Guo L, Wang H, et al. Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels. Neoplasia. 2010;12:748–54.
    • (2010) Neoplasia , vol.12 , pp. 748-754
    • Lin, Q.1    Balasubramanian, K.2    Fan, D.3    Kim, S.-J.4    Guo, L.5    Wang, H.6
  • 38
    • 84922762369 scopus 로고    scopus 로고
    • Role of the endothelin axis in astrocyte-and endothelial cell-mediated chemoprotection of cancer cells
    • PID: 2500809
    • Kim SW, Choi HJ, Lee H-J, He J, Wu Q, Langley RR, et al. Role of the endothelin axis in astrocyte-and endothelial cell-mediated chemoprotection of cancer cells. Neuro-Oncology. 2014;16:1585–98.
    • (2014) Neuro-Oncology , vol.16 , pp. 1585-1598
    • Kim, S.W.1    Choi, H.J.2    Lee, H.-J.3    He, J.4    Wu, Q.5    Langley, R.R.6
  • 39
    • 0034651980 scopus 로고    scopus 로고
    • Interleukin‐6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway
    • COI: 1:CAS:528:DC%2BD3cXpvVektA%3D%3D, PID: 1063919
    • Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC. Interleukin‐6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway. Prostate. 2000;42:239–42.
    • (2000) Prostate , vol.42 , pp. 239-242
    • Lou, W.1    Ni, Z.2    Dyer, K.3    Tweardy, D.J.4    Gao, A.C.5
  • 40
    • 33947414063 scopus 로고    scopus 로고
    • Significance of interleukin-6 (IL-6) in breast cancer (review)
    • PID: 1692717
    • Knüpfer H, Preiß R. Significance of interleukin-6 (IL-6) in breast cancer (review). Breast Cancer Res Treat. 2007;102:129–35.
    • (2007) Breast Cancer Res Treat , vol.102 , pp. 129-135
    • Knüpfer, H.1    Preiß, R.2
  • 41
    • 0034833541 scopus 로고    scopus 로고
    • Temozolomide for treating brain metastases: seminars in oncology
    • COI: 1:CAS:528:DC%2BD3MXntFGht7o%3
    • Abrey LE, Christodoulou C. Temozolomide for treating brain metastases: seminars in oncology. Elsevier. 2001;28:34–42.
    • (2001) Elsevier , vol.28 , pp. 34-42
    • Abrey, L.E.1    Christodoulou, C.2
  • 42
    • 0034005995 scopus 로고    scopus 로고
    • Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma
    • COI: 1:CAS:528:DC%2BD3cXjs1Wmsr8%3D, PID: 1079480
    • Agarwala SS, Kirkwood JM. Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma. Oncologist. 2000;5:144–51.
    • (2000) Oncologist , vol.5 , pp. 144-151
    • Agarwala, S.S.1    Kirkwood, J.M.2
  • 43
    • 34250221510 scopus 로고    scopus 로고
    • Increased permeability of the blood–brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm
    • PID: 1753817
    • Gerstner ER, Fine RL. Increased permeability of the blood–brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm. J Clin Oncol. 2007;25:2306–12.
    • (2007) J Clin Oncol , vol.25 , pp. 2306-2312
    • Gerstner, E.R.1    Fine, R.L.2
  • 44
    • 84907997688 scopus 로고    scopus 로고
    • Chapter seven—delivery of chemotherapeutics across the blood–brain barrier: challenges and advances
    • Advances in pharmacology, Academic Pres
    • Doolittle ND, Muldoon LL, Culp AY, Neuwelt EA. Chapter seven—delivery of chemotherapeutics across the blood–brain barrier: challenges and advances. In: Thomas PD, editors. Advances in pharmacology. Academic Press, 2014, Volume 71, pp 203–243.
    • (2014) Thomas PD, editors , vol.71 , pp. 203-243
    • Doolittle, N.D.1    Muldoon, L.L.2    Culp, A.Y.3    Neuwelt, E.A.4
  • 45
    • 42549164808 scopus 로고    scopus 로고
    • 2+ for cancer cell proliferation and survival
    • COI: 1:CAS:528:DC%2BD1cXltVGluro%3D, PID: 1843225
    • 2+ for cancer cell proliferation and survival. Nat Rev Cancer. 2008;8:361–75.
    • (2008) Nat Rev Cancer , vol.8 , pp. 361-375
    • Roderick, H.L.1    Cook, S.J.2
  • 46
    • 33847052535 scopus 로고    scopus 로고
    • Mechanisms of malignant glioma immune resistance and sources of immunosuppression
    • PID: 1681032
    • Gomez GG, Kruse CA. Mechanisms of malignant glioma immune resistance and sources of immunosuppression. Gene Ther Mol Biol. 2006;10:133.
    • (2006) Gene Ther Mol Biol , vol.10 , pp. 133
    • Gomez, G.G.1    Kruse, C.A.2
  • 47
    • 14644414825 scopus 로고    scopus 로고
    • New insights into the molecular mechanism of interleukin-10-mediated immunosuppression
    • PID: 1552291
    • Grütz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol. 2005;77:3–15.
    • (2005) J Leukoc Biol , vol.77 , pp. 3-15
    • Grütz, G.1
  • 48
    • 70349097179 scopus 로고    scopus 로고
    • Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
    • PID: 1930637
    • Zhang L, Alizadeh D, Van Handel M, Kortylewski M, Yu H, Badie B. Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice. Glia. 2009;57:1458–67.
    • (2009) Glia , vol.57 , pp. 1458-1467
    • Zhang, L.1    Alizadeh, D.2    Van Handel, M.3    Kortylewski, M.4    Yu, H.5    Badie, B.6
  • 49
    • 0028807156 scopus 로고
    • Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro
    • COI: 1:STN:280:DyaK287lvF2ntQ%3D%3D, PID: 858415
    • Hishii M, Nitta T, Ishida H, Ebato M, Kurosu A, Yagita H, et al. Human glioma-derived interleukin-10 inhibits antitumor immune responses in vitro. Neurosurgery. 1995;37:1160–7.
    • (1995) Neurosurgery , vol.37 , pp. 1160-1167
    • Hishii, M.1    Nitta, T.2    Ishida, H.3    Ebato, M.4    Kurosu, A.5    Yagita, H.6
  • 50
    • 42149111675 scopus 로고    scopus 로고
    • Inhibition of stat3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
    • COI: 1:CAS:528:DC%2BD1cXhsVSht7c%3D, PID: 1825041
    • Fujita M, Zhu X, Sasaki K, Ueda R, Low KL, Pollack IF, et al. Inhibition of stat3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J Immunol. 2008;180:2089–98.
    • (2008) J Immunol , vol.180 , pp. 2089-2098
    • Fujita, M.1    Zhu, X.2    Sasaki, K.3    Ueda, R.4    Low, K.L.5    Pollack, I.F.6
  • 51
    • 78651490601 scopus 로고    scopus 로고
    • Non-invasive quantification of brain tumor-induced astrogliosis
    • PID: 2124749
    • Lee J, Borboa AK, Baird A, Eliceiri BP. Non-invasive quantification of brain tumor-induced astrogliosis. BMC Neurosci. 2011;12:9.
    • (2011) BMC Neurosci , vol.12 , pp. 9
    • Lee, J.1    Borboa, A.K.2    Baird, A.3    Eliceiri, B.P.4


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