Low hemoglobin levels are associated with lower cerebral saturations and poor outcome after cardiac arrest

Resuscitation

Volumn 96, Issue , 2015, Pages 280-286

  Ameloot, K ^a   Genbrugge, C ^a,b   Meex, I ^a,b   Janssens, S ^c   Boer, W ^a   Mullens, W ^a,b   Ferdinande, B ^a   Dupont, M ^a   Dens, J ^a,b   De Deyne, C ^a,b  

^a DEPARTMENT OF CARDIOLOGY   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Cerebral saturation; Hemoglobin; Post cardiac arrest

Indexed keywords

HEMOGLOBIN;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; BRAIN OXYGEN TENSION; FEMALE; HEART ARREST; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOTHERMIA; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; OXYGEN SATURATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY ARTERY CATHETER; THERMAL REGULATING SYSTEM; BELGIUM; BLOOD; BRAIN; COMPLICATION; FOLLOW UP; INCIDENCE; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSIOLOGY; PROGNOSIS; SURVIVAL RATE; TRENDS;

BELGIUM; BRAIN; BRAIN ISCHEMIA; FEMALE; FOLLOW-UP STUDIES; HEART ARREST; HEMOGLOBINS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PROGNOSIS; PROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84944885682     PISSN: 03009572     EISSN: 18731570     Source Type: Journal    
DOI: 10.1016/j.resuscitation.2015.08.015     Document Type: Article

References (36)

1. Ameloot K., Meex I., Genbrugge C., et al. Hemodynamic targets during therapeutic hypothermia after cardiac arrest: a prospective observational study. Resuscitation 2015, 91:56-62.
2. Coetzee A., Swanepoel C. The oxyhemoglobin dissociation curve before, during and after cardiac surgery. Scand J Clin Lab Invest Suppl 1990, 203:149-153.
3. Hébert P.C., Wells G., Blajchman M.A., et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340:409-417.
4. Villanueva C., Colomo A., Bosch A., et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013, 368:11-21.
5. Carson J.L., Terrin M.L., Noveck H., et al. FOCUS Investigators. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011, 365:2453-2462.
6. Holst L.B., Haase N., Wetterslev J., et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 2014, 371:1381-1391. Scandinavian Critical Care Trials Group.
7. Carson J.L., Carless P.A., Hebert P.C. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2012, 4:CD002042.
8. Hébert P.C., Carson J.L. Transfusion threshold of 7g per deciliter - the new normal. N Engl J Med 2014, 371:1459-1461.
9. Meex I., Dens J., Jans F., et al. Cerebral tissue oxygen saturation during therapeutic hypothermia in post-cardiac arrest patients. Resuscitation 2013, 84:788-793.
10. Ameloot K., Meex I., Genbrugge C., et al. Accuracy of continuous thermodilution cardiac output monitoring by pulmonary artery catheter during therapeutic hypothermia in post-cardiac arrest patients. Resuscitation 2014, 85:1263-1268.
11. De Groot V., Beckerman H., Lankhorst G.J., Bouter L.M. How to measure comorbidity. A critical review of available methods. J Clin Epidemiol 2003, 56:221-229.
12. SOS-KANTO Study Group Relationship between the hemoglobin level at hospital arrival and post-cardiac arrest neurologic outcome. Am J Emerg Med 2012, 30:770-774.
13. Borgstrom L., Johannsson H., Siesjo B.K. The influence of acute normovolemic anemia on cerebral blood flow and oxygen consumption of anesthetized rats. Acta Physiol Scand 1975, 93:505-514.
14. Hare G.M., Mazer C.D., Hutchison J.S., et al. Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma. J Appl Physiol 2007, 103:1021-1029.
15. Zygun D.A., Nortje J., Hutchinson P.J., Timofeev I., Menon D.K., Gupta A.K. The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury. Crit Care Med 2009, 37:1074-1078.
16. Smith M.J., Stiefel M.F., Magge S., et al. Packed red blood cell transfusion increases local cerebral oxygenation. Crit Care Med 2005, 33:1104-1108.
17. Oddo M., Levine J.M., Kumar M., et al. Anemia and brain oxygen after severe traumatic brain injury. Intensive Care Med 2012, 38:1497-1504.
18. Tango H.K., Schmidt A.P., Mizumoto N., Lacava M., Cruz R.J., Auler J.O. Low hematocrit levels increase intracranial pressure in an animal model of cryogenic brain injury. J Trauma 2009, 66:720-726.
19. Marik P.E., Corwin H.L. Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36:2667-2674.
20. Carson J.L., Duff A., Poses R.M., et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996, 348:1055-1060.
21. Wu W.C., Rathore S.S., Wang Y., Radford M.J., Krumholz H.M. Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med 2001, 345:1230-1236.
22. Rao S.V., Jollis J.G., Harrington R.A., et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 2004, 292:1555-1562.
23. Salisbury A.C., Reid K.J., Marso S.P., et al. Blood transfusion during acute myocardial infarction: association with mortality and variability across hospitals. J Am Coll Cardiol 2014, 64:811-819.
24. Sekhon M.S., McLean N., Henderson W.R., Chittock D.R., Griesdale D.E. Association of hemoglobin concentration and mortality in critically ill patients with severe traumatic brain injury. Crit Care 2012, 16:R128.
25. Griesdale D.E., Sekhon M.S., Menon D.K., et al. Hemoglobin area and time index above 90g/L are associated with improved 6-month functional outcomes in patients with severe traumatic brain injury. Neurocrit Care 2014.
26. Carlson A.P., Schermer C.R., Lu S.W. Retrospective evaluation of anemia and transfusion in traumatic brain injury. J Trauma 2006, 61:567-571.
27. McIntyre L.A., Fergusson D.A., Hutchison J.S., et al. Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 2006, 5:4-9.
28. Warner M.A., O'Keeffe T., Bhavsar P., et al. Transfusions and long-term functional outcomes in traumatic brain injury. J Neurosurg 2010, 113:539-546.
29. Robertson C.S., Hannay H.J., Yamal J.M., et al. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA 2014, 312:36-47.
30. Korosue K., Heros R.C. Mechanism of cerebral blood flow augmentation by hemodilution in rabbits. Stroke 1992, 23:1487-1492.
31. Murphy G.J., Pike K., Rogers C.A., et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 2015, 372:997-1008.
32. Kwok CH C., Sherwood M., Watson S., et al. Blood transfusion after percutaneous coronary intervention and risk of subsequent adverse outcomes. A systematic review and meta-analysis. JACC: Cardiovasc Intervent 2015, 8:436-446.
33. Silvain J., Abtan J., Kerneis M., et al. Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: the TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry). J Am Coll Cardiol 2014, 63:1289-1296.
34. Hedström M., Flordal P.A., Ahl T., Svensson J., Dalén N. Autologous blood transfusion in hip replacement. No effect on blood loss but less increase of plasminogen activator inhibitor in a randomized series of 80 patients. Acta Orthop Scand 1996, 67:317-320.
35. Welch H.G., Meehan K.R., Goodnough L.T. Prudent strategies for elective red blood cell transfusion. Ann Intern Med 1992, 116:393-402.
36. Reynolds J.D., Ahearn G.S., Angelo M., Zhang J., Cobb F., Stamler J.S. S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A 2007, 104:17058-17062.