The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

Science

Volumn 350, Issue 6259, 2015, Pages 455-459

  Hung, T ^a   Pratt, G A ^b   Sundararaman, B ^b   Towsend, M J ^a   Chaivorapol, C ^a   Bhangale, T ^a   Graham, R R ^a   Ortmann, W ^a   Criswell, L A ^c   Yeo, G W ^b,d,e   Behrens, T W ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUTOANTIGEN; RNA BINDING PROTEIN; RO 60 ANTIGEN; UNCLASSIFIED DRUG; ANTIGEN ANTIBODY COMPLEX; AUTOANTIBODY; INTERFERON; RIBONUCLEOPROTEIN; RNA; SMALL CYTOPLASMIC RNA; TROVE2 PROTEIN, HUMAN;

ANTIBODY; ANTIGEN; BLOOD; CELLS AND CELL COMPONENTS; DISABILITY; GENE EXPRESSION; HOMINID; PROTEIN; RNA; SECRETION;

ALU SEQUENCE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RETROPOSON; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM;

ALU ELEMENTS; ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; AUTOANTIGENS; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, SYSTEMIC; RIBONUCLEOPROTEINS; RNA; RNA, SMALL CYTOPLASMIC; SJOGREN'S SYNDROME; TRANSCRIPTION, GENETIC;

EID: 84944810495     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7442     Document Type: Article

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