Rotenone attenuates renal injury in aldosterone-infused rats by inhibiting oxidative stress, mitochondrial dysfunction, and inflammasome activation

Medical Science Monitor

Volumn 21, Issue , 2015, Pages 3136-3143

  Ding, Wei ^a   Xu, Chengyan ^b   Wang, Bin ^b   Zhang, Minmin ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Aldosterone; Inflammasomes; Reactive oxygen species; Renal insufficiency, chronic

Indexed keywords

ALDOSTERONE; CONNECTIVE TISSUE GROWTH FACTOR; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; MALONALDEHYDE; ROTENONE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; MITOCHONDRIAL DNA; NLRP3 PROTEIN, RAT; REACTIVE OXYGEN METABOLITE; RELA PROTEIN, RAT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEINURIA; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; FOCAL GLOMERULOSCLEROSIS; INJURIES; KIDNEY; METABOLISM; MITOCHONDRION; PATHOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ALDOSTERONE; ANIMALS; CARRIER PROTEINS; DNA, MITOCHONDRIAL; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; IMMUNOHISTOCHEMISTRY; INFLAMMASOMES; INFLAMMATION; KIDNEY; MALE; MALONDIALDEHYDE; MICROSCOPY, ELECTRON; MITOCHONDRIA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OXIDATIVE STRESS; PROTEINURIA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; ROTENONE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TRANSCRIPTION FACTOR RELA;

EID: 84944768888     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.895945     Document Type: Article

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