Bronchial reactivity, inflammatory and allergic parameters, and vitamin D levels in children with asthma

Respiratory Care

Volumn 60, Issue 8, 2015, Pages 1157-1163

  Dabbah, Husein ^a,b   Bar Yoseph, Ronen ^c   Livnat, Galit ^c   Hakim, Fahed ^c   Bentur, Lea ^c,d  

^a WESTERN GALILEE HOSPITAL   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

^c MEYER CHILDREN S HOSPITAL   (Israel)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Airway hyper responsiveness; Allergic parameters; Asthma; Fractional exhaled NO; High sensitivity C reactive protein; Vitamin D

Indexed keywords

IMMUNOGLOBULIN E; METHACHOLINE; NITRIC OXIDE; VITAMIN D; AUTACOID; BIOLOGICAL MARKER; BRONCHOCONSTRICTING AGENT; C REACTIVE PROTEIN; METHACHOLINE CHLORIDE;

ADOLESCENT; ADULT; ALLERGIC RHINITIS; ARTICLE; ASTHMA; BRONCHUS REACTIVITY; CHILD; CONTROLLED STUDY; EOSINOPHIL COUNT; FEMALE; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; RADIOIMMUNOASSAY; SPIROMETRY; VITAMIN BLOOD LEVEL; BLOOD; COMPLICATION; EOSINOPHIL; HYPERSENSITIVITY; INHALATION TEST; LEUKOCYTE COUNT; PATHOPHYSIOLOGY; PROCEDURES; RESPIRATORY EXCRETION;

ADOLESCENT; ASTHMA; BIOMARKERS; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; C-REACTIVE PROTEIN; CHILD; EOSINOPHILS; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; INFLAMMATION MEDIATORS; LEUKOCYTE COUNT; MALE; METHACHOLINE CHLORIDE; NITRIC OXIDE; PULMONARY ELIMINATION; SPIROMETRY; VITAMIN D;

EID: 84944746393     PISSN: 00201324     EISSN: 19433654     Source Type: Journal    
DOI: 10.4187/respcare.03763     Document Type: Article

References (46)

1. Boulet LP, FitzGerald JM, Reddel HK. The revised 2014 GINA strategy report: opportunities for change. Curr Opin Pulm Med 2015; 21(1):1-7.
2. Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH, Sterk PJ. External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma. Thorax 2015;70(2):115-120.
3. Lloyd CM, Hessel EM. Functions of T cells in asthma: more than just TH2 cells. Nat Rev Immunol 2010;10(12):838-848.
4. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59(5):469-478.
5. Moorman JE, Rudd RA, Johnson CA, King M, Minor P, Bailey C, et al. National surveillance for asthma–United States, 1980-2004. MMWR CDC Surveill Summ 2007;56(8):1-54.
6. Holick MF. Vitamin D deficiency in 2010: health benefits of vitamin D and sunlight: a D-bate. Nat Rev Endocrinol 2011;7(2):73-75.
7. Djennane M, Lebbah S, Roux C, Djoudi H, Cavalier E, Souberbielle JC. Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency. Osteoporos Int 2014;25(5):1493-1502.
8. Vu LH, Whiteman DC, van der Pols JC, Kimlin MG, Neale RE. Serum vitamin D levels in office workers in a subtropical climate. Photochem Photobiol 2011;87(3):714-720.
9. Freishtat RJ, Iqbal SF, Pillai DK, Klein CJ, Ryan LM, Benton AS, Teach SJ. High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr 2010;156(6):948-952.
10. Alyasin S, Momen T, Kashef S, Alipour A, Amin R. The relationship between serum 25 hydroxyvitamin D levels and asthma in children. Allergy Asthma Immunol Res 2011;3(4):251-255.
11. Camargo CA Jr, Rifas-Shiman SL, Litonjua AA, Rich-Edwards JW, Weiss ST, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr 2007;85(3):788-795.
12. Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 2007;85(3):853-859.
13. Hollams EM, Hart PH, Holt BJ, Serralha M, Parsons F, de Klerk NH, et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur Respir J 2011;38(6):1320-1327.
14. Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 2010;126(1):52e5-58e5.
15. Brehm JM, Celedón JC, Soto-Quiros ME, Avila L, Hunninghake GM, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med 2009;179(9):765-771.
16. Burns JS, Dockery DW, Neas LM, Schwartz J, Coull BA, Raizenne M, Speizer FE. Low dietary nutrient intakes and respiratory health in adolescents. Chest 2007;132(1):238-245.
17. Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011;158(3):437-441.
18. Chinellato I, Piazza M, Sandri M, Peroni DG, Cardinale F, Piacentini GL, Boner AL. Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma. Eur Respir J 2011;37(6): 1366-1370.
19. Bratke K, Wendt A, Garbe K, Kuepper M, Julius P, Lommatzsch M, Virchow JC. Vitamin D binding protein and vitamin D in human allergen-induced endobronchial inflammation. Clin Exp Immunol 2014;177(1):366-372.
20. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 2002;109(1):45-60.
21. Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010;125(5):995-1000.
22. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995;152(3):1107-1136.
23. Quanjer PH, Borsboom GJ, Brunekreef B, Zach M, Forche G, Cotes JE, et al. Spirometric reference values for white European children and adolescents: Polgar revisited. Pediatr Pulmonol 19(2)95;19:135-142.
24. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing—1999. Am J Respir Crit Care Med 2000;161(1):309-329.
25. American Thoracic Society, European Respiratory Society. ATS/ ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171(8):912-930.
26. Hossein-nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS ONE 2013;8(3):e58725.
27. Lemire JM, Archer DC, Beck L, Spiegelberg HL. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 1995;125(6 Suppl):1704S–1708S.
28. Somashekar AR, Prithvi AB, Gowda MN. Vitamin D levels in children with bronchial asthma. J Clin Diagn Res 2014;8(10):PC04-PC07.
29. Yao TC, Tu YL, Chang SW, Tsai HJ, Gu PW, Ning HC, et al. Serum 25-hydroxyvitamin D levels in relation to lung function and exhaled nitric oxide in children. J Pediatr 2014;165(6):1098-1103.
30. Niruban SJ, Alagiakrishnan K, Beach J, Senthilselvan A. Association of vitamin D with respiratory outcomes in Canadian children. Eur J Clin Nutr 2014;68(12):1334-1340.
31. Wu AC. Effect of vitamin D and inhaled corticosteroid treatment on lung function in children. Am J Respir Crit Care Med 2012;186(6): 508-513.
32. Devereux G, Wilson A, Avenell A, McNeill G, Fraser WD. A case control study of vitamin D status and asthma in adults. Allergy 2010;65(5):666-667.
33. Krobtrakulchai W, Praikanahok J, Visitsunthorn N, Vichyanond P, Manonukul K, Pratumvinit B, Jirapongsananuruk O. The effect of vitamin D status on pediatric asthma at a university hospital, Thailand. Allergy Asthma Immunol Res 2013;5(5):289-294.
34. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med 2010;181(7):699-704.
35. Bar Yoseph R, Bentur L, Goldbart A, Livnat G, Hakim F, Weisman Y, Tiosano D. A mutated vitamin D receptor in hereditary vitamin D-resistant rickets prevents induction of bronchial hyperreactivity and inflammation. J Clin Endocrinol Metab 2014;99(9):E1610–E1616.
36. Bar Yoseph R, Livnat G, Schnapp Z, Hakim F, Dabbah H, Goldbart A, Bentur L. The effect of vitamin D on airway reactivity and inflammation in asthmatic children: a double-blind placebo-controlled trial. Pediatr Pulmonol 2014. doi: 10.1002/ppul.23076.
37. Sunyer J, Pistelli R, Plana E, Andreani M, Baldari F, Kolz M, et al. Systemic inflammation, genetic susceptibility and lung function. Eur Respir J 2008;32(1):92-97.
38. Yao TC, Tu YL, Chang SW, Tsai HJ, Gu PW, Ning HC, et al. Suboptimal vitamin D status in a population-based study of Asian children: prevalence and relation to allergic diseases and atopy. PLoS ONE 2014;9(6):e99105.
39. Dogru M, Kirmizibekmez H, Yesiltepe Mutlu RG, Aktas A, Ozturkmen S. Clinical effects of vitamin D in children with asthma. Int Arch Allergy Immunol 2014;164(4):319-325.
40. Uysalol M, Mutlu LC, Saracoglu GV, Karasu E, Guzel S, Kayaoglu S, Uzel N. Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Ital J Pediatr 2013;39:78.
41. Rajabbik MH, Lotfi T, Alkhaled L, Fares M, El-Hajj Fuleihan G, Mroueh S, Akl EA. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol 2014;10(1):31.
42. Wjst M. The vitamin D slant on allergy. Pediatr Allergy Immunol 2006;17(7):477-483.
43. Lange NE, Litonjua A, Hawrylowicz CM, Weiss S. Vitamin D, the immune system and asthma. Expert Rev Clin Immunol 2009;5(6): 693-702.
44. Hyppönen E, Sovio U, Wjst M, Patel S, Pekkanen J, Hartikainen AL, Ja¨rvelinb MR. Infant vitamin D supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann NY Acad Sci 2004;1037:84-95.
45. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA 2014;311(20):2083-2091.
46. Iordanidou M, Paraskakis E, Giannakopoulou E, Tavridou A, Gentile G, Borro M, et al. Vitamin D receptor ApaI a allele is associated with better childhood asthma control and improvement in ability for daily activities. OMICS 2014;18(11):673-681.