Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive

Science

Volumn 350, Issue 6259, 2015, Pages 442-445

  Miyata, Haruhiko ^a   Satouh, Yuhkoh ^a   Mashiko, Daisuke ^a,b   Muto, Masanaga ^a,c   Nozawa, Kaori ^a,b   Shiba, Kogiku ^d   Fujihara, Yoshitaka ^a   Isotani, Ayako ^c   Inaba, Kazuo ^d   Ikawa, Masahito ^a,b,c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; TACROLIMUS; CALCINEURIN; CYCLOSPORIN; MALE CONTRACEPTIVE AGENT; PPP3CC PROTEIN, MOUSE; PPP3R2 PROTEIN, MOUSE;

CONTRACEPTIVE USE; DRUG; FERTILITY; GENE EXPRESSION; HOMINID; IMMUNOASSAY; INHIBITION; MALE; MOTILITY; PROTEIN; REPRODUCTIVE BIOLOGY; RODENT; SPERM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTRACEPTION; CONTROLLED STUDY; GENE; HUMAN; HUMAN CELL; MALE; MALE FERTILITY; MOUSE; NONHUMAN; PPP3CC GENE; PRIORITY JOURNAL; SPERMATOGENESIS; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; ANIMAL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; EPIDIDYMIS; FERTILITY; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; MALE INFERTILITY; PHYSIOLOGY; SPERMATOZOON; TESTIS;

MUS;

ANIMALS; CALCINEURIN; CALCINEURIN INHIBITORS; CONTRACEPTIVE AGENTS, MALE; CYCLOSPORINE; EPIDIDYMIS; FERTILITY; HEK293 CELLS; HUMANS; INFERTILITY, MALE; MALE; MICE; MICE, KNOCKOUT; SPERM MOTILITY; SPERMATOZOA; TACROLIMUS; TESTIS;

EID: 84944720225     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad0836     Document Type: Article

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