Relationship Between Bariatric Surgery and Bone Mineral Density: a Meta-analysis

Obesity Surgery

Volumn 26, Issue 7, 2016, Pages 1414-1421

  Ko, Byung Joon ^a   Myung, Seung Kwon ^b   Cho, Kyung Hwan ^c   Park, Yong Gyu ^d   Kim, Sin Gon ^c   Kim, Do Hoon ^c   Kim, Seon Mee ^c  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

Bariatric surgery; Bone density; DXA; Meta analysis

Indexed keywords

BARIATRIC SURGERY; BONE DENSITY; COCHRANE LIBRARY; EMBASE; FEMUR NECK; GASTRIC BANDING; HUMAN; LUMBAR SPINE; MEDLINE; META ANALYSIS; MORBID OBESITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; REVIEW; ROUX Y ANASTOMOSIS; SLEEVE GASTRECTOMY; STOMACH BYPASS; FEMORAL NECK; LUMBAR VERTEBRA; OSTEOPOROSIS; PHOTON ABSORPTIOMETRY;

ABSORPTIOMETRY, PHOTON; BARIATRIC SURGERY; BONE DENSITY; FEMUR NECK; HUMANS; LUMBAR VERTEBRAE; OBESITY, MORBID; OSTEOPOROSIS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES;

EID: 84944707598     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-015-1928-8     Document Type: Review

References (37)

1. Angrisani L, Santonicola A, Iovino P, et al. Bariatric Surgery Worldwide 2013. Obes Surg. 2015;25(11):2166–8.
2. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292(14):1724–37.
3. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122(3):248–56. e5.
4. Goldner WS, O’Dorisio TM, Dillon JS, et al. Severe metabolic bone disease as a long-term complication of obesity surgery. Obes Surg. 2002;12(5):685–92.
5. Carrasco F, Ruz M, Rojas P, et al. Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery. Obes Surg. 2009;19(1):41–6.
6. Shaker JL, Norton AJ, Woods MF, et al. Secondary hyperparathyroidism and osteopenia in women following gastric exclusion surgery for obesity. Osteoporos Int. 1991;1(3):177–81.
7. Ricci TA, Heymsfield SB, Pierson Jr RN, et al. Moderate energy restriction increases bone resorption in obese postmenopausal women. Am J Clin Nutr. 2001;73(2):347–52.
8. Parfitt AM, Podenphant J, Villanueva AR, et al. Metabolic bone disease with and without osteomalacia after intestinal bypass surgery: a bone histomorphometric study. Bone. 1985;6(4):211–20.
9. Ammann P, Rizzoli R. Bone strength and its determinants. Osteoporos Int. 2003;14 Suppl 3:S13–8.
10. Lewiecki EM. Bone densitometry and vertebral fracture assessment. Curr Osteoporos Rep. 2010;8(3):123–30.
11. Bolotin HH. DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling. Bone. 2007;41(1):138–54.
12. Scibora LM, Ikramuddin S, Buchwald H, et al. Examining the link between bariatric surgery, bone loss, and osteoporosis: a review of bone density studies. Obes Surg. 2012;22(4):654–67.
13. Viegas M, Vasconcelos RS, Neves AP, et al. Bariatric surgery and bone metabolism: a systematic review. Arq Bras Endocrinol Metabol. 2010;54(2):158–63.
14. Rodriguez-Carmona Y, Lopez-Alavez FJ, Gonzalez-Garay AG, et al. Bone mineral density after bariatric surgery. A systematic review. Int J Surg. 2014;12(9):976–82.
15. Liu C, Wu D, Zhang JF, et al. Changes in bone metabolism in morbidly obese patients after bariatric surgery: a meta-analysis. Obes Surg. 2015.
16. Stein EM, Carrelli A, Young P, et al. Bariatric surgery results in cortical bone loss. J Clin Endocrinol Metab. 2013;98(2):541–9.
17. Fleischer J, Stein EM, Bessler M, et al. The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss. J Clin Endocrinol Metab. 2008;93(10):3735–40.
18. Yu EW, Bouxsein ML, Roy AE, et al. Bone loss after bariatric surgery: discordant results between DXA and QCT bone density. J Bone Miner Res. 2014;29(3):542–50.
19. Abegg K, Gehring N, Wagner CA, et al. Roux-en-Y gastric bypass surgery reduces bone mineral density and induces metabolic acidosis in rats. Am J Physiol Regul Integr Comp Physiol. 2013;305(9):R999–R1009.
20. Yu EW, Bouxsein ML, Putman MS, et al. Two-year changes in bone density after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2015;100(4):1452–9. doi:10.1210/jc.2014-4341.
21. Slater GH, Ren CJ, Siegel N, et al. Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J Gastrointest Surg. 2004;8(1):48–55. discussion 4-5.
22. Stemmer K, Bielohuby M, Grayson BE, et al. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rats. Endocrinology. 2013;154(6):2015–24.
23. Cornish J, Callon KE, Bava U, et al. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol. 2002;175(2):405–15.
24. Holloway WR, Collier FM, Aitken CJ, et al. Leptin inhibits osteoclast generation. J Bone Miner Res. 2002;17(2):200–9.
25. Terra X, Auguet T, Guiu-Jurado E, et al. Long-term changes in leptin, chemerin and ghrelin levels following different bariatric surgery procedures: Roux-en-Y gastric bypass and sleeve gastrectomy. Obes Surg. 2013;23(11):1790–8.
26. Biver E, Salliot C, Combescure C, et al. Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96(9):2703–13.
27. Olbers T, Bjorkman S, Lindroos A, et al. Body composition, dietary intake, and energy expenditure after laparoscopic Roux-en-Y gastric bypass and laparoscopic vertical banded gastroplasty: a randomized clinical trial. Ann Surg. 2006;244(5):715–22.
28. Chaston TB, Dixon JB, O’Brien PE. Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes. 2007;31(5):743–50.
29. Ott MT, Fanti P, Malluche HH, et al. Biochemical evidence of metabolic bone disease in women following Roux-Y gastric bypass for morbid obesity. Obes Surg. 1992;2(4):341–8.
30. Guney E, Kisakol G, Ozgen G, et al. Effect of weight loss on bone metabolism: comparison of vertical banded gastroplasty and medical intervention. Obes Surg. 2003;13(3):383–8.
31. Goode LR, Brolin RE, Chowdhury HA, et al. Bone and gastric bypass surgery: effects of dietary calcium and vitamin D. Obes Res. 2004;12(1):40–7.
32. Von Mach MA, Stoeckli R, Bilz S, et al. Changes in bone mineral content after surgical treatment of morbid obesity. Metabolism. 2004;53(7):918–21.
33. Pereira FA, de Castro JA, dos Santos JE, et al. Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling. Braz J Med Biol Res. 2007;40(4):509–17.
34. Valderas JP, Velasco S, Solari S, et al. Increase of bone resorption and the parathyroid hormone in postmenopausal women in the long-term after roux-en-y gastric bypass. Obes Surg. 2009;19(8):1132–8.
35. de Vasconcelos RS, Viegas M, Marques TF, et al. Factors associated with secondary hyperparathyroidism in premenopausal women undergoing Roux-en-y gastric bypass for the treatment of obesity. Arq Bras Endocrinol Metabol. 2010;54(2):233–8.
36. Hintze LJ, Cremon AS, Bevilaqua CA, et al. Factors associated with bone mineral density in women who underwent bariatric surgery. Acta Sci Health Sci. 2014;36(1):105–12.
37. Costa TL, Paganotto M, Radominski RB, et al. Calcium metabolism, vitamin D and bone mineral density after bariatric surgery. Osteoporosis Int. 2015;26(2):757–64.