Bone loss after bariatric surgery: Discordant results between DXA and QCT bone density

Journal of Bone and Mineral Research

Volumn 29, Issue 3, 2014, Pages 542-550

  Yu, Elaine W ^a   Bouxsein, Mary L ^a   Roy, Adam E ^a   Baldwin, Chantel ^a   Cange, Abby ^a   Neer, Robert M ^a   Kaplan, Lee M ^a   Finkelstein, Joel S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

bone metabolism; dual energy X ray absorptiometry; gastric bypass; osteoporosis; quantitative computed tomography; soft tissue artifact

Indexed keywords

BONE METABOLISM; DUAL-ENERGY X-RAY ABSORPTIOMETRY; GASTRIC BYPASS; OSTEOPOROSIS; QUANTITATIVE COMPUTED TOMOGRAPHY; SOFT TISSUE ARTIFACT;

ABSORPTIOMETRY, PHOTON; ADULT; BARIATRIC SURGERY; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY, MORBID; OSTEOPOROSIS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84894456561     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2063     Document Type: Article

References (39)

1. Flegal KM, Carroll MD, Ogden CL, Curtin LR., Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010; 303 (3): 235-41.
2. Buchwald H, Oien DM., Metabolic/bariatric surgery Worldwide 2008. Obes Surg. 2009; 19 (12): 1605-11.
3. Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012; 366 (17): 1567-76.
4. Mingrone G, Panunzi S, De Gaetano A, et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012; 366 (17): 1577-85.
5. Sjöström L, Peltonen M, Jacobson P, et al. Bariatric surgery,long-term cardiovascular events. JAMA. 2012; 307 (1): 56-65.
6. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007; 357 (8): 741-52.
7. Coates PS, Fernstrom JD, Fernstrom MH, Schauer PR, Greenspan SL., Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass. J Clin Endocrinol Metab. 2004; 89 (3): 1061-5.
8. von Mach MA, Stoeckli R, Bilz S, Kraenzlin M, Langer I, Keller U., Changes in bone mineral content after surgical treatment of morbid obesity. Metab Clin Exp. 2004; 53 (7): 918-21.
9. Johnson JM, Maher JW, Samuel I, Heitshusen D, Doherty C, Downs RW., Effects of gastric bypass procedures on bone mineral density, calcium, parathyroid hormone, and vitamin D. J Gastrointest Surg. 2005; 9 (8): 1106-10; discussion 1110-1.
10. Pereira FA, de Castro JAS, dos Santos JE, Foss MC, Paula FJA., Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling. Braz J Med Biol Res. 2007; 40 (4): 509-17.
11. Mahdy T, Atia S, Farid M, Adulatif A., Effect of Roux-en Y gastric bypass on bone metabolism in patients with morbid obesity: mansoura experiences. Obes Surg. 2008; 18 (12): 1526-31.
12. Fleischer J, Stein EM, Bessler M, et al. The decline in hip bone density after gastric bypass surgery is associated with extent of weight loss. J Clin Endocrinol Metab. 2008; 93 (10): 3735-40.
13. Carrasco F, Ruz M, Rojas P, et al. Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after bariatric surgery. Obes Surg. 2009; 19 (1): 41-6.
14. Vilarrasa N, San José P, García I, et al. Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up. Obes Surg. 2011; 21 (4): 465-72.
15. Duran de Campos C, Dalcanale L, Pajecki D, Garrido AB, Halpern A., Calcium intake and metabolic bone disease after eight years of Roux-en-Y gastric bypass. Obes Surg. 2008; 18 (4): 386-90.
16. Bernstein CN, Leslie WD, Leboff MS., AGA technical review on osteoporosis in gastrointestinal diseases. Gastroenterology. 2003; 124 (3): 795-841.
17. Lalmohamed A, De Vries F, Bazelier MT, et al. Risk of fracture after bariatric surgery in the United Kingdom: population based,retrospective cohort study. BMJ. 2012; 345: e5085.
18. Melton LJ 3rd, Crowson CS, Khosla S, O'Fallon WM., Fracture risk after surgery for peptic ulcer disease: a population-based cohort study. Bone. 1999; 25 (1): 61-7.
19. Nilsson BE, Westlin NE., The fracture incidence after gastrectomy. Acta Chir Scand. 1971; 137 (6): 533-4.
20. Brzozowska MM, Sainsbury A, Eisman JA, Baldock PA, Center JR., Bariatric surgery, bone loss, obesity and possible mechanisms. Obes Rev. 2013; 14 (1): 52-6.
21. Bolotin HH., DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling. Bone. 2007; 41 (1): 138-54.
22. Yu EW, Thomas BJ, Brown JK, Finkelstein JS., Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT. J Bone Miner Res. 2012; 27 (1): 119-2.
23. Binkley N, Krueger D, Vallarta-Ast N., An overlying fat panniculus affects femur bone mass measurement. J Clin Densitom. 2003; 6 (3): 199-204.
24. Evans EM, Mojtahedi MC, Kessinger RB, Misic MM., Simulated change in body fatness affects Hologic QDR 4500A whole body and central DXA bone measures. J Clin Densitom. 2006; 9 (3): 315-22.
25. Tothill P, Laskey MA, Orphanidou CI, van Wijk M., Anomalies in dual energy X-ray absorptiometry measurements of total-body bone mineral during weight change using Lunar, Hologic and Norland instruments. Br J Radiol. 1999; 72 (859): 661-9.
26. Svendsen OL, Haarbo J, Hassager C, Christiansen C., Accuracy of measurements of body composition by dual-energy x-ray absorptiometry in vivo. Am J Clin Nutr. 1993; 57 (5): 605-8.
27. Kriska AM, Knowler WC, LaPorte RE, et al. Development of questionnaire to examine relationship of physical activity and diabetes in Pima Indians. Diabetes Care. 1990; 13 (4): 401-11.
28. Knapp KM, Welsman JR, Hopkins SJ, Fogelman I, Blake GM., Obesity increases precision errors in dual-energy X-ray absorptiometry measurements. J Clin Densitom. 2012; 15 (3): 315-9.
29. Nelson L, Gulenchyn KY, Atthey M, Webber CE., Is a fixed value for the least significant change appropriate ? J Clin Densitom. 2010; 13 (1): 18-23.
30. Blake GM, Parker JC, Buxton FM, Fogelman I., Dual X-ray absorptiometry: a comparison between fan beam and pencil beam scans. Br J Radiol. 1993; 66 (790): 902-6.
31. Gluer CC, Reiser UJ, Davis CA, Rutt BK, Genant HK., Vertebral mineral determination by quantitative computed tomography (QCT): accuracy of single and dual energy measurements. J Comput Assist Tomogr. 1988; 12 (2): 242-58.
32. Sran MM, Khan KM, Keiver K, Chew JB, McKay HA, Oxland TR., Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume. Eur Spine J. 2005; 14 (10): 971-6.
33. Weigert JM, Cann CE., Dual-energy X-ray absorptiometry (DXA) in obese patients: are normal values really normal ? J Women's Imaging. 1999; 1 (1): 11-7.
34. Barrett JF, Keat N., Artifacts in CT: recognition and avoidance. Radiographics. 2004; 24 (6): 1679-91.
35. Sowers MF, Zheng H, Greendale GG, Neer RM, Ellis J, Johnson S, Finkelstein JS., Changes in bone resorption across the menopause transition: effects of reproductive hormones, body size, and ethnicity. J Clin Endocrinol Metab. 2013; 98 (7): 2854-63.
36. Villareal DT, Fontana L, Weiss EP, et al. Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med. 2006; 166 (22): 2502-10.
37. Shane E., Bone loss and turnover after cardiac transplantation. J Clin Endocrinol Metab. 1997; 82 (5): 1497-506.
38. Smith SM, Wastney ME, O'Brien KO, et al. Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the mir space station. J Bone Miner Res. 2005; 20 (2): 208-18.
39. Bruno C, Fulford AD, Potts JR, et al. Serum markers of bone turnover are increased at six and 18 months after Roux-en-Y bariatric surgery: correlation with the reduction in leptin. J Clin Endocrinol Metab. 2010; 95 (1): 159-66.