High cell density culture with S. cerevisiae CEN.PK113-5D for IL-1β production: Optimization, modeling, and physiological aspects

Bioprocess and Biosystems Engineering

Volumn 38, Issue 2, 2015, Pages 251-261

  Landi, Carmine ^a   Paciello, Lucia ^a   De Alteriis, Elisabetta ^b   Brambilla, Luca ^c   Parascandola, Palma ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Auxotrophic yeasts; High cell density cultures; Metabolic shift; S. cerevisiae; Yeast growth modeling

Indexed keywords

BATCH DATA PROCESSING; BATCH REACTORS; CELLS; CYTOLOGY; GLUCOSE; METABOLISM; POPULATION STATISTICS; YEAST;

FED-BATCH PROCESS; HIGH CELL DENSITY CULTURES; METABOLIC SHIFT; PHYSIOLOGICAL MARKERS; RECOMBINANT STRAINS; S.CEREVISIAE; SPECIFIC GROWTH RATE; YEAST GROWTH;

PHYSIOLOGY;

ACETIC ACID; ALCOHOL; GLUCOSE; INTERLEUKIN 1BETA; OXYGEN; REACTIVE OXYGEN METABOLITE; METHANOL; RECOMBINANT PROTEIN;

ALCOHOL CONSUMPTION; ALCOHOL PRODUCTION; ARTICLE; BIOMASS FERMENTATION; BIOMASS PRODUCTION; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE OPTIMIZATION; CYTOKINE PRODUCTION; FED BATCH CULTURE; FED BATCH REACTOR; FUNGAL STRAIN; GLUCOSE INTAKE; HUMAN; NONHUMAN; OXYGEN SUPPLY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE CEN.PK113-5D; BATCH CELL CULTURE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL COUNT; CLASSIFICATION; COMPUTER SIMULATION; GENETIC ENHANCEMENT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PROCEDURES; SPECIES DIFFERENCE;

BATCH CELL CULTURE TECHNIQUES; CELL COUNT; CELL PROLIFERATION; COMPUTER SIMULATION; GENETIC ENHANCEMENT; GLUCOSE; HUMANS; INTERLEUKIN-1BETA; METHANOL; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SPECIES SPECIFICITY;

EID: 84944675989     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-014-1264-8     Document Type: Article

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