Glutamine and skeletal muscle

Glutamine in Clinical Nutrition

Volumn , Issue , 2015, Pages 499-511

  Tirapegui, Julio ^a   Cruzat, Vinicius Fernandes ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Amino acids; Glutamate; Glutathione; Heat shock proteins; Supplementation

Indexed keywords

EID: 84944549075     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4939-1932-1_38     Document Type: Chapter

References (48)

1. Curi R, Lagranha CJ, Doi SQ, Sellitti DF, Procopio J, Pithon-Curi TC. Glutamine-dependent changes in gene expression and protein activity. Cell Biochem Funct. 2005;23:77-84.
2. Newsholme P, Procopio J, Lima MMR, Pithon-Curi TC, Curi R. Glutamine and glutamate - their central role in cell metabolism and function. Cell Biochem Funct. 2003;21:1-9.
3. Neu J, Shenoy V, Chakrabarti R. Glutamine nutrition and metabolism: where do we go from here? FASEB J. 1996;10:829-37.
4. Labow BI, Souba WW, Abcouwer SF. Mechanisms governing the expression of the enzymes of glutamine metabolism-glutaminase and glutamine synthetase. J Nutr. 2001;131 Suppl 9:2467S-74.
5. Rogero MM, Borelli P, Vinolo MA, Fock RA, Pires ISD, Tirapegui J. Dietary glutamine supplementation affects macrophage function, hematopoiesis and nutritional status in early weaned mice. Clin Nutr. 2008;27:386-97.
6. Flaring UB, Rooyackers OE, Wernerman J, Hammarqvist F. Glutamine attenuates post-traumatic glutathione depletion in human muscle. Clin Sci. 2003;104:275-82.
7. Cruzat VF, Tirapegui J. Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise. Nutrition. 2009;25:428-35.
8. Shimomura Y, Murakami T, Nakai N, Nagasaki M, Harris RA. Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise. J Nutr. 2004;134:1583S-7.
9. Newsholme P, Lima MMR, Porcopio J, et al. Glutamine and glutamate as vital metabolites. Braz J Med Biol Res. 2003;36:153-63.
10. Walsh NP, Blannin AK, Clark AM, Cook L, Robson PJ, Gleeson M. The effects of high-intensity intermittent exercise on the plasma concentrations of glutamine and organic acids. Eur J Appl Physiol Occup Physiol. 1998;77:434-8.
11. Rowbottom DG, Keast D, Morton AR. The emerging role of glutamine as an indicator of exercise stress and overtraining. Sports Med. 1996;21:80-97.
12. Manso Filho HC, McKeever KH, Gordon ME, et al. Developmental changes in the concentrations of glutamine and other amino acids in plasma and skeletal muscle of the standard bred foal. J Anim Sci. 2009;87:2528-35.
13. Graham TE, MacLean DA. Ammonia and amino acid metabolism in skeletal muscle: human, rodent and canine models. Med Sci Sports Exerc. 1998;30:34-46.
14. Curi R, Newsholme P, Procopio J, Lagranha C, Gorjao R, Pithon-Curi TC. Glutamine, gene expression, and cell function. Front Biosci. 2007;12:344-57.
15. Usher-Smith JA, Huang CLH, Fraser JA. Control of cell volume in skeletal muscle. Biol Rev. 2009;84:143-59.
16. Galley HF. Oxidative stress and mitochondrial dysfunction in sepsis. Br J Anaesth. 2011;107:57-64.
17. Whillier S, Garcia B, Chapman BE, Kuchel PW, Raftos JE. Glutamine and alpha-ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes. FEBS J. 2011;278:3152-63.
18. Dam A, Mitchell A, Rush JE, Quadrilatero J. Elevated skeletal muscle apoptotic signaling following glutathione depletion. Apoptosis. 2012;17:48-60.
19. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-47.
20. Cruzat VF, Rogero MM, Ou AK, Pires ISO, Tirapegui J. Effect of alanyl-glutamine supplementation on muscle damage in rats submitted to exhaustive exercise. Ann Nutr Metab. 2007;51:386-7.
21. Lamb GD, Westerblad H. Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle. J Physiol. 2011;589:2119-27.
22. Powers SK, Talbert EE, Adhihetty PJ. Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J Physiol. 2011;589(Pt 9):2129-38.
23. Kim M, Wischmeyer PE. Glutamine. World Rev Nutr Diet. 2013;105:90-6.
24. Heck TG, Scholer CM, de Bittencourt PI. HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain? Cell Biochem Funct. 2011;29:215-26.
25. Xue H, Slavov D, Wischmeyer PE. Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. J Biol Chem. 2012;287:40400-13.
26. Singleton KD, Wischmeyer PE. Glutamine’s protection against sepsis and lung injury is dependent on heat shock protein 70 expression. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1839-45.
27. Meador BM, Huey KA. Glutamine preserves skeletal muscle force during an inflammatory insult. Muscle Nerve. 2009;40:1000-7.
28. Lightfoot A, McArdle A, Griffiths RD. Muscle in defense. Crit Care Med. 2009;37:S384-90.
29. Rogero MM, Borges MC, Fock RA, et al. Glutamine in vitro supplementation decreases glucose utilization by the glycolytic pathway in Lps-activated peritoneal macrophages. Ann Nutr Metab. 2009;55:455.
30. Nässl A-M, Rubio-Aliaga I, Fenselau H, Marth MK, Kottra G, Daniel H. Amino acid absorption and homeostasis in mice lacking the intestinal peptide transporter PEPT1. Am J Physiol Gastrointest Liver Physiol. 2011; 301:G128-37.
31. Ingersoll SA, Ayyadurai S, Charania MA, Laroui H, Yan Y, Merlin D. The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2012;302:G484-92.
32. Rogero MM, Tirapegui J, Pedrosa RG, de Castro IA, Pires ISD. Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats submitted to exhaustive exercise. Nutrition. 2006;22:564-71.
33. Cruzat VF, Rogero MM, Tirapegui J. Effects of supplementation with free glutamine and the dipeptide alanylglutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochem Funct. 2010;28:24-30.
34. Ziegler TR, Young LS, Benfell K, et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Intern Med. 1992;116:821-8.
35. Grau T, Bonet A, Minambres E, et al. The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients. Crit Care Med. 2011;39:1263-8.
36. Wernerman J. Clinical use of glutamine supplementation. J Nutr. 2008;138:2040S-4.
37. Krause MS, de Bittencourt PIHJ. Type 1 diabetes: can exercise impair the autoimmune event? The L-arginine/glutamine coupling hypothesis. Cell Biochem Funct. 2008;26:406-33.
38. Newsholme P, Krause M, Newsholme EA, Stear SJ, Burke LM, Castell LM. A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part18. Br J Sports Med. 2011; 45:230-2.
39. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr. 2001;131(9 Suppl):2515S-22.
40. Newsholme P, Abdulkader F, Rebelato E, et al. Amino acids and diabetes: implications for endocrine, metabolic and immune function. Front Biosci. 2011;16:315-39.
41. Menge BA, Schrader H, Ritter PR, et al. Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes. Regul Pept. 2010;160(1-3):75-80.
42. Krause M, Rodrigues-Krause J, O’Hagan C, et al. Differential nitric oxide levels in the blood and skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a preliminary study. Metabolism. 2012;61:1528-37.
43. Rodrigues-Krause J, Krause M, O’Hagan C, et al. Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter? Cell Stress Chaperones. 2012;17:293-302.
44. Rogero MM, Tirapegui J, Pedrosa RG, Pires ISD, de Castro IA. Plasma and tissue glutamine response to acute and chronic supplementation with L-glutamine and L-alanyl-L-glutamine in rats. Nutr Res. 2004;24:261-70.
45. Newsholme P, Bender K, Kiely A, Brennan L. Amino acid metabolism, insulin secretion and diabetes. Biochem SocTrans. 2007;35(Pt 5):1180-6.
46. Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci. 2005;108:185-94.
47. Cunningham GA, McClenaghan NH, Flatt PR, Newsholme P. L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis. Clin Sci. 2005;109:447-55.
48. Harris RC, Hoffman JR, Allsopp A, Routledge NB. L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutr Res. 2012;32:272-7.