A poxviral-based cancer vaccine targeting the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model

Oncotarget

Volumn 6, Issue 29, 2015, Pages 28194-28210

  Kwilas, Anna R ^a   Ardiani, Andressa ^a   Dirmeier, Ulrike ^b,c   Wottawah, Cornelia ^b,c   Schlom, Jeffery ^a   Hodge, James W ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Bavarian Nordic GmbH   (Germany)

^c NONE   (United States)

Author keywords

Immunotherapy; Metastasis; TRICOM; Twist; Vaccine

Indexed keywords

B7 ANTIGEN; CANCER VACCINE; ENZALUTAMIDE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MODIFIED VACCINIA VIRUS ANKARA VACCINE; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; RECOMBINANT VACCINE; RV-TRICOM; TWIST RELATED PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER MODEL; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TARGETING; FEMALE; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MALE; METASTASIS INHIBITION; MONOTHERAPY; MOUSE; NONHUMAN; POXVIRIDAE; PROSTATE CANCER; TRANSGENE; TUMOR MICROENVIRONMENT; TWIST GENE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MAMMARY NEOPLASMS, ANIMAL; METABOLISM; METASTASIS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TRANSGENIC MOUSE; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR VOLUME; VACCINATION; VACCINIA VIRUS;

ANIMALS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MALE; MAMMARY NEOPLASMS, ANIMAL; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASM METASTASIS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TUMOR BURDEN; TWIST-RELATED PROTEIN 1; VACCINATION; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 84944463330     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4442     Document Type: Article

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