Cancer vaccines targeting the epithelial-mesenchymal transition: Tissue distribution of brachyury and other drivers of the mesenchymal-like phenotype of carcinomas

Seminars in Oncology

Volumn 39, Issue 3, 2012, Pages 358-366

  Hamilton, Duane H ^a   Litzinger, Mary T ^a   Fernando, Romaine I ^a   Huang, Bruce ^a   Palena, Claudia ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRACHYURY; CANCER VACCINE; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOMA; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TUMOR BIOPSY;

ANIMALS; CANCER VACCINES; CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; FETAL PROTEINS; HUMANS; NEOPLASM INVASIVENESS; PHENOTYPE; T-BOX DOMAIN PROTEINS;

EID: 84861157570     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2012.02.005     Document Type: Article

References (63)

1. J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 2002 442 454
2. P. Savagner Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition Bioessays 23 2001 912 923 (Pubitemid 32972691)
3. R. Kalluri, R.A. Weinberg The basics of epithelial-mesenchymal transition J Clin Invest 119 2009 1420 1428
4. J.P. Thiery, J.P. Sleeman Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 7 2006 131 142 (Pubitemid 43278296)
5. T.T. Onder, P.B. Gupta, S.A. Mani, J. Yang, E.S. Lander, R.A. Weinberg Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways Cancer Res 68 2008 3645 3654
6. M. Guarino, B. Rubino, G. Ballabio The role of epithelial-mesenchymal transition in cancer pathology Pathology 39 2007 305 318 (Pubitemid 46897605)
7. S.A. Mani, W. Guo, M.J. Liao The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715 (Pubitemid 351636299)
8. K. Polyak, R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat Rev Cancer 9 2009 265 273
9. S. Thomson, E. Buck, F. Petti Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition Cancer Res 65 2005 9455 9462 (Pubitemid 41508014)
10. A. Cano, M.A. Perez-Moreno, I. Rodrigo The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat Cell Biol 2 2000 76 83
11. M.J. Blanco, G. Moreno-Bueno, D. Sarrio Correlation of Snail expression with histological grade and lymph node status in breast carcinomas Oncogene 21 2002 3241 3246 (Pubitemid 34548095)
12. V. Bolos, H. Peinado, M.A. Perez-Moreno, M.F. Fraga, M. Esteller, A. Cano The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors J Cell Sci 116 2003 499 511 (Pubitemid 36231290)
13. J.Y. Shih, M.F. Tsai, T.H. Chang Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma Clin Cancer Res 11 2005 8070 8078
14. J. Yang, S.A. Mani, J.L. Donaher Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 2004 927 939 (Pubitemid 38798858)
15. W.K. Kwok, M.T. Ling, T.W. Lee Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target Cancer Res 65 2005 5153 5162 (Pubitemid 40827324)
16. C. Palena, D.E. Polev, K.Y. Tsang The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy Clin Cancer Res 13 2007 2471 2478 (Pubitemid 46698599)
17. R.I. Fernando, M. Litzinger, P. Trono, D.H. Hamilton, J. Schlom, C. Palena The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells J Clin Invest 120 2010 533 544
18. S. Elloul, M.B. Elstrand, J.M. Nesland Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma Cancer 103 2005 1631 1643 (Pubitemid 40490024)
19. M. Shioiri, T. Shida, K. Koda, K. Oda Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients Br J Cancer 94 2006 1816 1822 (Pubitemid 43882571)
20. K. Shibata, H. Kajiyama, K. Ino Twist expression in patients with cervical cancer is associated with poor disease outcome Ann Oncol 19 2008 81 85
21. N. Kilic, S. Feldhaus, E. Kilic Brachyury expression predicts poor prognosis at early stages of colorectal cancer Eur J Cancer 47 2011 1080 1085
22. A. Zhang, G. Chen, L. Meng Antisense-Snail transfer inhibits tumor metastasis by inducing E-cadherin expression Anticancer Res 28 2008 621 628 (Pubitemid 351578901)
23. M.A. Smit, T.R. Geiger, J.Y. Song, I. Gitelman, D.S. Peeper A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis Mol Cell Biol 29 2009 3722 3737
24. A.E. Parent, C. Choi, K. Caudy, T. Gridley, D.F. Kusewitt The developmental transcription factor slug is widely expressed in tissues of adult mice J Histochem Cytochem 52 2004 959 965 (Pubitemid 38857160)
25. W.A. Paznekas, K. Okajima, M. Schertzer, S. Wood, E.W. Jabs Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P) Genomics 62 1999 42 49
26. S.M. Wang, V.W. Coljee, R.J. Pignolo, M.O. Rotenberg, V.J. Cristofalo, F. Sierra Cloning of the human twist gene: its expression is retained in adult mesodermally-derived tissues Gene 187 1997 83 92 (Pubitemid 27110438)
27. G.A. Calin, C.M. Croce MicroRNA signatures in human cancers Nat Rev Cancer 6 2006 857 866 (Pubitemid 44629897)
28. R.S. Pillai MicroRNA function: multiple mechanisms for a tiny RNA? RNA 11 2005 1753 1761 (Pubitemid 41720024)
29. J.R. Gingrich, R.J. Barrios, R.A. Morton Metastatic prostate cancer in a transgenic mouse Cancer Res 56 1996 4096 4102 (Pubitemid 26304996)
30. K. Raina, S. Rajamanickam, R.P. Singh, G. Deep, M. Chittezhath, R. Agarwal Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model Cancer Res 68 2008 6822 6830
31. S.E. Moody, C.J. Sarkisian, K.T. Hahn Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis Cancer Cell 2 2002 451 461 (Pubitemid 41043950)
32. S.E. Moody, D. Perez, T.C. Pan The transcriptional repressor Snail promotes mammary tumor recurrence Cancer Cell 8 2005 197 209 (Pubitemid 41317591)
33. K.E. Inman, K.M. Downs Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation Gene Expr Patterns 6 2006 783 793 (Pubitemid 44309433)
34. B.A. Foster, J.R. Gingrich, E.D. Kwon, C. Madias, N.M. Greenberg Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model Cancer Res 57 1997 3325 3330 (Pubitemid 27355467)
35. T. Reya, S.J. Morrison, M.F. Clarke, I.L. Weissman Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111 (Pubitemid 33041634)
36. X. Li, M.T. Lewis, J. Huang Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy J Natl Cancer Inst 100 2008 672 679
37. S. Bao, Q. Wu, R.E. McLendon Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature 444 2006 756 760 (Pubitemid 44949604)
38. M. Dean, T. Fojo, S. Bates Tumour stem cells and drug resistance Nat Rev Cancer 5 2005 275 284 (Pubitemid 40488633)
39. M. Diehn, M.F. Clarke Cancer stem cells and radiotherapy: new insights into tumor radioresistance J Natl Cancer Inst 98 2006 1755 1757 (Pubitemid 46017927)
40. C.J. Creighton, X. Li, M. Landis Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features Proc Natl Acad Sci U S A 106 2009 13820 13825
41. A.T. Collins, P.A. Berry, C. Hyde, M.J. Stower, N.J. Maitland Prospective identification of tumorigenic prostate cancer stem cells Cancer Res 65 2005 10946 10951 (Pubitemid 41713363)
42. A. Eramo, F. Lotti, G. Sette Identification and expansion of the tumorigenic lung cancer stem cell population Cell Death Differ 15 2008 504 514 (Pubitemid 351267301)
43. P.C. Hermann, S.L. Huber, T. Herrler Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Cell Stem Cell 1 2007 313 323 (Pubitemid 47355323)
44. C.A. O'Brien, A. Pollett, S. Gallinger, J.E. Dick A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Nature 445 2007 106 110 (Pubitemid 46067310)
45. E.H. Huang, M.J. Hynes, T. Zhang Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis Cancer Res 69 2009 3382 3389
46. C. Ginestier, M.H. Hur, E. Charafe-Jauffret ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 1 2007 555 567 (Pubitemid 350056407)
47. E. Charafe-Jauffret, C. Ginestier, F. Iovino Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature Cancer Res 69 2009 1302 1313
48. U.I. Ezeh, P.J. Turek, R.A. Reijo, A.T. Clark Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma Cancer 104 2005 2255 2265 (Pubitemid 41579973)
49. C.R. Jeter, M. Badeaux, G. Choy Functional evidence that the self-renewal gene NANOG regulates human tumor development Stem Cells 27 2009 993 1005
50. M. Monk, C. Holding Human embryonic genes re-expressed in cancer cells Oncogene 20 2001 8085 8091 (Pubitemid 34028332)
51. D.A. Hess, T.E. Meyerrose, L. Wirthlin Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity Blood 104 2004 1648 1655 (Pubitemid 39202270)
52. M. Peichev, A.J. Naiyer, D. Pereira Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors Blood 95 2000 952 958 (Pubitemid 30062717)
53. N. Uchida, D.W. Buck, D. He Direct isolation of human central nervous system stem cells Proc Natl Acad Sci U S A 97 2000 14720 14725 (Pubitemid 32016642)
54. A.H. Yin, S. Miraglia, E.D. Zanjani AC133, a novel marker for human hematopoietic stem and progenitor cells Blood 90 1997 5002 5012 (Pubitemid 28007217)
55. P.V. Bhat, H. Samaha Kinetic properties of the human liver cytosolic aldehyde dehydrogenase for retinal isomers Biochem Pharmacol 57 1999 195 197 (Pubitemid 29056181)
56. M.B. Kastan, E. Schlaffer, J.E. Russo, O.M. Colvin, C.I. Civin, J. Hilton Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells Blood 75 1990 1947 1950
57. P.B. Gupta, C.L. Chaffer, R.A. Weinberg Cancer stem cells: mirage or reality? Nat Med 15 2009 1010 1012
58. J.P. Thiery Epithelial-mesenchymal transitions in development and pathologies Curr Opin Cell Biol 15 2003 740 746 (Pubitemid 37487967)
59. P.B. Gupta, T.T. Onder, G. Jiang Identification of selective inhibitors of cancer stem cells by high-throughput screening Cell 138 2009 645 659
60. P.W. Kantoff, C.S. Higano, N.D. Shore Sipuleucel-T immunotherapy for castration-resistant prostate cancer N Engl J Med 363 2010 411 422
61. P.W. Kantoff, T.J. Schuetz, B.A. Blumenstein Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer J Clin Oncol 28 2010 1099 1105
62. C.M. Fillmore, C. Kuperwasser Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy Breast Cancer Res 10 2008 R25
63. M. Todaro, M.P. Alea, A.B. Di Stefano Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4 Cell Stem Cell 1 2007 389 402 (Pubitemid 47506537)