A phase II study of active immunotherapy with PANVACTM or autologous, cultured dendritic cells infected with PANVACTM after complete resection of hepatic metastases of colorectal carcinoma

Clinical Colorectal Cancer

Volumn 5, Issue 5, 2006, Pages 368-371

  Lou, Emil ^a   Marshall, John ^b   Aklilu, Mebea ^c   Cole, David ^d   Chang, David ^e   Morse, Michael ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c WAKE FOREST BAPTIST HEALTH   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e UNIVERSITY OF TEXAS   (United States)

Author keywords

Granulocyte monocyte colony stimulating factor; Performance status; Pox vectors

Indexed keywords

ANTINEOPLASTIC AGENT; DENDRITIC CELL VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PANVAC; VIRUS VACCINE;

ACTIVE IMMUNIZATION; ARTICLE; CANCER PATIENT; CANCER RECURRENCE; CANCER SURVIVAL; CELL CULTURE; CLINICAL TRIAL; COLORECTAL CARCINOMA; DENDRITIC CELL; DRUG HYPERSENSITIVITY; DRUG SAFETY; FOLLOW UP; FOWLPOX VIRUS; HUMAN; IMMUNOHISTOCHEMISTRY; INJECTION SITE ERYTHEMA; INJECTION SITE INDURATION; LIVER FUNCTION TEST; LIVER METASTASIS; LYMPHOCYTIC INFILTRATION; PHYSICAL EXAMINATION; RANDOMIZATION; SURVIVAL RATE; T LYMPHOCYTE; TREATMENT OUTCOME; TREATMENT PLANNING; VACCINIA VIRUS; VIRUS VECTOR;

EID: 33244454544     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2006.n.009     Document Type: Article

References (15)

1. Jaeck D, Bachellier P, Guiguet M, et al. Long-term survival following resection of colorectal hepatic metastases. Association Francaise de Chirurgie. Br J Surg 1997; 84:977-980.
2. Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999; 230:309-318.
3. Gayowski TJ, Iwatsuki S, Madariaga. JR, et al. Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery 1994; 116:703-710.
4. Lorenz M, Muller HH, Schramm H, et al. Randomized trial of surgery versus surgery followed by adjuvant hepatic arterial infusion with 5-fluorouracil and folinic acid for liver metastases of colorectal cancer. Ann Surg 1998; 228:756-762.
5. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med 1999; 341:2039-2048.
6. Kemeny MM, Adak S, Gray B, et al. Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy-an intergroup study. J Clin Oncol 2002; 20:1499-1505.
7. Nordlinger B, Rougier P. Liver metastases from colorectal cancer: the turning point. J Clin Oncol 2002; 20:1442-1445.
8. Nagorsen D, Scheibenbogen C, Marincola FM, et al. Natural T cell immunity against cancer. Clin Cancer Res 2003; 9:4296-4303.
9. Mazzaferro V, Coppa J, Carrabba MG, et al. Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin Cancer Res 2003; 9:3235-3245.
10. Hanna MG Jr, Hoover HC Jr, Vermorken JB, et al. Adjuvant active specific immunnotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise. Vaccine 2001; 19:576-2582.
11. Levy B, Deeken JF, Holt G, et al. Immunologic therapies for gastrointestinal cancers. Clin Colorectal Cancer 2005; 5:37-49.
12. Marshall JM, Gulley JL, Arlen PM, et al. Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D))-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J Clin Oncol 2005; 23:720-731.
13. Adams S, O'Neill DW, Bhardwaj N. Recent advances in dendritic cell biology. J Clin Immunol 2005; 25:177-188.
14. Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005; 5:296-306.
15. Tsang KY, Palena C, Yokokawa J, et al. Analyses of recombinant vaccinia and fowlpox vaccine vectors expressing transgenes for two human tumor antigens and three human costimulatory molecules. Clin Cancer Res 2005; 11:1597-1607.