Proneness of TLR5 deficient mice to develop colitis is microbiota dependent

Gut Microbes

Volumn 6, Issue 4, 2015, Pages 279-283

  Singh, Vishal ^a   Yeoh, Beng San ^a   Carvalho, Frederic ^b   Gewirtz, Andrew T ^c   Vijay Kumar, Matam ^a,d  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b Universite d’Auvergne ^*  (France)

^c GEORGIA STATE UNIVERSITY   (United States)

^d PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Germ free mice; Gut bacteria; Interleukin 10; Intestinal inflammation; Toll like receptor

Indexed keywords

AMPICILLIN; INTERLEUKIN 10; LIPOCALIN; MYELOPEROXIDASE; NEOMYCIN; TOLL LIKE RECEPTOR 5; ANTIINFECTIVE AGENT; IL10 PROTEIN, MOUSE; INTERLEUKIN 10 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GERMFREE ANIMAL; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; MICROFLORA; MOUSE; NONHUMAN; RAT; SPLENOMEGALY; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; INTESTINE FLORA; KNOCKOUT MOUSE; PATHOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; COLITIS; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; INTERLEUKIN-10; MICE; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN-10; TOLL-LIKE RECEPTOR 5;

EID: 84944447464     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.1080/19490976.2015.1060390     Document Type: Article

References (18)

1. Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, et al. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Investig 2007; 117:3909-21; PMID:18008007
2. Bamias G, Okazawa A, Rivera-Nieves J, Arseneau KO, De La Rue SA, Pizarro TT, Cominelli F. Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis. J Immunol 2007; 178:1809-18; PMID:17237431; http://dx. doi.org/10.4049/jimmunol.178.3.1809
3. Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cellmediated inflammation. Immunity 2011; 34:566-78; PMID:21511185; http://dx.doi.org/10.1016/j. immuni.2011.03.018
4. Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, et al. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun 2012; 3:1120; PMID:23047678; http://dx.doi. org/10.1038/ncomms2113
5. Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, et al. Interleukin-1beta (IL-1beta) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2012; 61:373-84; PMID:21646247; http://dx.doi.org/10.1136/ gut.2011.240556
6. Sellon RK, Tonkonogy S, Schultz M, Dieleman LA, Grenther W, Balish E, Rennick DM, Sartor RB. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998; 66:5224-31; PMID:9784526
7. Dicksved J, Halfvarson J, Rosenquist M, Jarnerot G, Tysk C, Apajalahti J, Engstrand L, Jansson JK. Molecular analysis of the gut microbiota of identical twins with Crohn's disease. ISME J 2008; 2:716-27; PMID:18401439; http://dx.doi.org/10.1038/ ismej.2008.37
8. Letran SE, Lee SJ, Atif SM, Flores-Langarica A, Uematsu S, Akira S, Cunningham AF, McSorley SJ. TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen. J Immunol 2011; 186:5406-12; PMID:21451112; http://dx. doi.org/10.4049/jimmunol.1003576
9. Olson TS, Reuter BK, Scott KG, Morris MA, Wang XM, Hancock LN, Burcin TL, Cohn SM, Ernst PB, Cominelli F, et al. The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med 2006; 203:541-52; PMID:16505137; http://dx. doi.org/10.1084/jem.20050407
10. Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 2006; 55:1263-9; PMID:16682432; http://dx.doi.org/10.1136/ gut.2005.079343
11. Pastorelli L, Garg RR, Hoang SB, Spina L, Mattioli B, Scarpa M, Fiocchi C, Vecchi M, Pizarro TT. Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc Natl Acad Sci U S A 2010; 107:8017-22; PMID:20385815; http://dx.doi.org/ 10.1073/pnas.0912678107
12. Barnes SL, Vidrich A, Wang ML, Wu GD, Cominelli F, Rivera-Nieves J, Bamias G, Cohn SM. Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. J Immunol 2007; 179:7012-20; PMID:17982092; http://dx.doi.org/10.4049/ jimmunol.179.10.7012
13. Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, et al. Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell host & microbe 2012; 12:139-52; PMID:22863420; http://dx.doi.org/ 10.1016/j.chom.2012.07.004
14. Chassaing B, Ley RE, Gewirtz AT. Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 2014; 147:1363-77 e17; PMID:25172014; http://dx.doi.org/10.1053/j. gastro.2014.08.033
15. Zhang J, Fu S, Sun S, Li Z, Guo B. Inflammasome activation has an important role in the development of spontaneous colitis. Mucosal Immunol 2014; 7:1139-50; PMID:24472848; http://dx.doi.org/10.1038/ mi.2014.1
16. Coccia M, Harrison OJ, Schiering C, Asquith MJ, Becher B, Powrie F, Maloy KJ. IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(C) Th17 cells. J Exp Med 2012; 209:1595-609; PMID:22891275; http://dx.doi.org/10.1084/ jem.20111453
17. Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D. Role of interleukin 1 in inflammatory bowel disease-enhanced production during active disease. Gut 1990; 31:686-9; PMID:2379873; http://dx.doi.org/10.1136/ gut.31.6.686
18. Chassaing B, Srinivasan G, Delgado MA, Young AN, Gewirtz AT, Vijay-Kumar M. Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PloS one 2012; 7:e44328; PMID:22957064; http://dx.doi.org/10.1371/journal. pone.0044328