Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

Nature Biotechnology

Volumn 33, Issue 7, 2015, Pages 733-735

  Lyon, Robert P ^a   Bovee, Tim D ^a   Doronina, Svetlana O ^a   Burke, Patrick J ^a   Hunter, Joshua H ^a   Neff Laford, Haley D ^a   Jonas, Mechthild ^a   Anderson, Martha E ^a   Setter, Jocelyn R ^a   Senter, Peter D ^a  

^a SEATTLE GENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROPHOBICITY;

ANTIBODY-DRUG CONJUGATES; IN-VITRO; IN-VIVO; PEGYLATED; PLASMA CLEARANCES; THERAPEUTIC INDEX;

ANTIBODIES;

ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; UNCLASSIFIED DRUG; VEDOTIN; DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DESIGN; DRUG FORMULATION; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; THERAPEUTIC INDEX; ANIMAL; CELL LINE; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; MEDICINAL CHEMISTRY; SCID MOUSE;

ANIMALS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOCONJUGATES; MICE; MICE, SCID; MODELS, CHEMICAL; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS;

EID: 84944441047     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3212     Document Type: Article

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