Basal ganglia pathology in ALS is associated with neuropsychological deficits

Neurology

Volumn 85, Issue 15, 2015, Pages 1301-1309

  Machts, Judith ^a,b   Loewe, Kristian ^b   Kaufmann, Joern ^b   Jakubiczka, Sibylle ^b,c   Abdulla, Susanne ^a   Petri, Susanne ^c   Dengler, Reinhard ^c   Heinze, Hans Jochen ^a,b,d   Vielhaber, Stefan ^a,b   Schoenfeld, Mircea Ariel ^b,d,e   Bede, Peter ^f  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^e Kliniken Schmieder   (Germany)

^f TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; AMYOTROPHIC LATERAL SCLEROSIS FUNCTIONAL RATING SCALE REVISED; ARTICLE; BACKWARD DIGIT SPAN; BASAL GANGLION; BRAIN REGION; CAUDATE NUCLEUS; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FRONTAL SYSTEMS BEHAVIOR SCALE; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; GLOBUS PALLIDUS; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE ASSESSMENT; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; PATHOLOGY; PRIORITY JOURNAL; PUTAMEN; QUANTITATIVE ANALYSIS; STROOP TEST; THALAMUS; TRAIL MAKING TEST; VERBAL MEMORY TEST; AGED; ATROPHY; COGNITIVE DEFECT; FRONTOTEMPORAL DEMENTIA; MEMORY; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; ATROPHY; BASAL GANGLIA; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; MIDDLE AGED;

EID: 84944395872     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000002017     Document Type: Article

References (40)

1. Phukan J, Elamin M, Bede P, et al. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: A population-based study. J Neurol Neurosurg Psychiatry 2012; 83: 102-108
2. Pradat PF, Bruneteau G, Munerati E, et al. Extrapyramidal stiffness in patients with amyotrophic lateral sclerosis. Mov Disord 2009; 24: 2143-2148
3. Brettschneider J, Del Tredici K, Toledo JB, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol 2013; 74: 20-38
4. Girardi A, Macpherson SE, Abrahams S. Deficits in emotional and social cognition in amyotrophic lateral sclerosis. Neuropsychology 2011; 25: 53-65
5. Abrahams S. Executive dysfunction in ALS is not the whole story. J Neurol Neurosurg Psychiatry 2013; 84: 474-475
6. Machts J, Bittner V, Kasper E, et al. Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: A comparative neuropsychological study of amnestic mild cognitive impairment. BMC Neurosci 2014; 15: 83
7. O'Callaghan C, Bertoux M, Hornberger M. Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration. J Neurol Neurosurg Psychiatry 2014; 85: 371-378
8. Brownell B, Oppenheimer DR, Hughes JT. The central nervous system in motor neurone disease. J Neurol Neurosurg Psychiatry 1970; 33: 338-357
9. Westeneng HJ, Verstraete E, Walhout R, et al. Subcortical structures in amyotrophic lateral sclerosis. Neurobiol Aging 2015; 36: 1075-1082
10. Bede P, Elamin M, Byrne S, et al. Basal ganglia involvement in amyotrophic lateral sclerosis. Neurology 2013; 81: 2107-2115
11. Thivard L, Pradat PF, Lehericy S, et al. Diffusion tensor imaging and voxel based morphometry study in amyotrophic lateral sclerosis: relationships with motor disability. J Neurol Neurosurg Psychiatry 2007; 78: 889-892
12. Sharma KR, Saigal G, Maudsley AA, Govind V. 1H MRS of basal ganglia and thalamus in amyotrophic lateral sclerosis. NMR Biomed 2011; 24: 1270-1276
13. Agosta F, Gorno-Tempini ML, Pagani E, et al. Longitudinal assessment of grey matter contraction in amyotrophic lateral sclerosis: A tensor based morphometry study. Amyotroph Lateral Scler 2009; 10: 168-174
14. Pinkhardt EH, Van Elst LT, Ludolph AC, Kassubek J. Amygdala size in amyotrophic lateral sclerosis without dementia: an in vivo study using MRI volumetry. BMC Neurol 2006; 6: 48
15. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986; 9: 357-381
16. Rascovsky K, Hodges JR, Knopman D, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011; 134: 2456-2477
17. Strong MJ, Grace GM, Freedman M, et al. Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 2009; 10: 131-146
18. Bede P, Bokde AL, Byrne S, et al. Multiparametric MRI study of ALS stratified for the C9orf72 genotype. Neurology 2013; 81: 361-369
19. Patenaude B, Smith SM, Kennedy DN, Jenkinson MA. Bayesian model of shape and appearance for subcortical brain segmentation. Neuroimage 2011; 56: 907-922
20. Jack CR Jr, Twomey CK, Zinsmeister AR, Sharbrough FW, Petersen RC, Cascino GD. Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults. Radiology 1989; 172: 549-554
21. Winkler AM, Ridgway GR, Webster MA, Smith SM, Nichols TE. Permutation inference for the general linear model. Neuroimage 2014; 92: 381-397
22. Smith SM, Nichols TE. Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage 2009; 44: 83-98
23. Freedman D, Lane D. A nonstochastic interpretation of reported significance levels. J Bus Econ Stat 1983; 1: 292-298
24. Douaud G, Filippini N, Knight S, Talbot K, Turner MR. Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. Brain 2011; 134: 3470-3479
25. Elamin M, Phukan J, Bede P, et al. Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia. Neurology 2011; 76: 1263-1269
26. Olney RK, Murphy J, Forshew D, et al. The effects of executive and behavioral dysfunction on the course of ALS. Neurology 2005; 65: 1774-1777
27. Takeda T, Uchihara T, Arai N, Mizutani T, Iwata M. Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease. Acta Neuropathol 2009; 117: 35-44
28. Abdulla S, Machts J, Kaufmann J, et al. Hippocampal degeneration in patients with amyotrophic lateral sclerosis. Neurobiol Aging 2014; 35: 2639-2645
29. Stoppel CM, Vielhaber S, Eckart C, et al. Structural and functional hallmarks of amyotrophic lateral sclerosis progression in motor- and memory-related brain regions. Neuroimage Clin 2014; 5: 277-290
30. Bede P, Bokde A, Elamin M, et al. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): A neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. J Neurol Neurosurg Psychiatry 2013; 84: 766-773.
31. Poston KL, Eidelberg D. Functional brain networks and abnormal connectivity in the movement disorders. Neuroimage 2012; 62: 2261-2270
32. Lawrence AD, Watkins LH, Sahakian BJ, Hodges JR, Robbins TW. Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. Brain 2000; 123: 1349-1364
33. Phukan J, Pender NP, Hardiman O. Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol 2007; 6: 994-1003
34. Elamin M, Bede P, Byrne S, et al. Cognitive changes predict functional decline in ALS: A population-based longitudinal study. Neurology 2013; 80: 1590-1597
35. McGinty VB, Lardeux S, Taha SA, Kim JJ, Nicola SM. Invigoration of reward seeking by cue and proximity encoding in the nucleus accumbens. Neuron 2013; 78: 910-922
36. Mackenzie IR, Frick P, Neumann M. The neuropathology associated with repeat expansions in the C9ORF72 gene. Acta Neuropathol 2014; 127: 347-357
37. Bede P, Elamin M, Byrne S, et al. Patterns of cerebral and cerebellar white matter degeneration in ALS. J Neurol Neurosurg Psychiatry 2015; 86: 468-470
38. Tan RH, Devenney E, Dobson-Stone C, et al. Cerebellar integrity in the amyotrophic lateral sclerosis-frontotemporal dementia continuum. PLoS One 2014; 9: e105632
39. Chang JL, Lomen-Hoerth C, Murphy J, et al. A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. Neurology 2005; 65: 75-80
40. Garibotto V, Borroni B, Agosti C, et al. Subcortical and deep cortical atrophy in frontotemporal lobar degeneration. Neurobiol Aging 2011; 32: 875-884