Management of squamous cancer metastatic to cervical nodes with an unknown primary site

Journal of Clinical Oncology

Volumn 33, Issue 29, 2015, Pages 3328-3337

  Galloway, Thomas J ^a   Ridge, John A ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FLUORODEOXYGLUCOSE F 18;

CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER OF UNKNOWN PRIMARY SITE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CERVICAL LYMPH NODE; CHEMORADIOTHERAPY; CLINICAL FEATURE; CLINICAL PROTOCOL; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; GLOSSECTOMY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; INDUCTION CHEMOTHERAPY; LARYNGOSCOPY; LYMPH NODE METASTASIS; NECK DISSECTION; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; SURGICAL TECHNIQUE; TONGUE CARCINOMA; TONSIL CARCINOMA; TONSILLECTOMY; TREATMENT OUTCOME; TUMOR BIOPSY; WART VIRUS; CARCINOMA, SQUAMOUS CELL; HEAD AND NECK NEOPLASMS; MULTIMODALITY CANCER THERAPY; NEOPLASMS, UNKNOWN PRIMARY; PATHOLOGY; SECONDARY;

CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHATIC METASTASIS; NEOPLASMS, UNKNOWN PRIMARY;

EID: 84944251594     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2015.61.0063     Document Type: Review

References (70)

1. Martin M: Cervical lymph node metastasis as the first symptom of cancer. Surgery, Gynecology, and Obstetrics 78: 133-159, 1944
2. National Comprehensive Cancer Network: Head and Neck Cancer. V2.2013. http: //oralcancer foundation.org/treatment/pdf/head-and-neck.pdf
3. Grau C, Johansen LV, Jakobsen J, et al: Cervical lymph node metastases from unknown primary tumours: Results from a national survey by the Danish Society for Head and Neck Oncology. Radiother Oncol 55: 121-129, 2000
4. Keller LM, Galloway TJ, Holdbrook T, et al: P16 status, pathologic and clinical characteristics, biomolecular signature, and long term outcomes in unknown primary carcinomas of the head and neck. Head Neck 36: 1677-1684, 2014
5. Galloway TJ, Davis KS, Burtness B, et al: HPV association and the increase in unknown primary head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 88: 494, 2014 (abstr 101)
6. Jesse RH, Perez CA, Fletcher GH: Cervical lymph node metastasis: Unknown primary cancer. Cancer 31: 854-859, 1973
7. Ligey A, Gentil J, Crehange G, et al: Impact of target volumes and radiation technique on locoregional control and survival for patients with unilateral cervical lymph node metastases from an unknown primary. Radiother Oncol 93: 483-487, 2009
8. Frank SJ, Rosenthal DI, Petsuksiri J, et al: Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 78: 1005-1010, 2010
9. Chen AM, Farwell DG, Lau DH, et al: Radiation therapy in the management of head-and-neck cancer of unknown primary origin: How does the addition of concurrent chemotherapy affect the therapeutic ratio? Int J Radiat Oncol Biol Phys 81: 346-352, 2011
10. Demiroz C, Vainshtein JM, Koukourakis GV, et al: Head and neck squamous cell carcinoma of unknown primary: Neck dissection and radiotherapy or definitive radiotherapy. Head Neck 36: 1589-1595, 2014
11. Wang RC, Goepfert H, Barber AE, et al: Unknown primary squamous cell carcinoma metastatic to the neck. Arch Otolaryngol Head Neck Surg 116: 1388-1393, 1990
12. Iganej S, Kagan R, Anderson P, et al: Metastatic squamous cell carcinoma of the neck from an unknown primary: Management options and patterns of relapse. Head Neck 24: 236-246, 2002
13. Colletier PJ, Garden AS, Morrison WH, et al: Postoperative radiation for squamous cell carcinoma metastatic to cervical lymph nodes from an unknown primary site: Outcomes and patterns of failure. Head Neck 20: 674-681, 1998
14. Reddy SP, Marks JE: Metastatic carcinoma in the cervical lymph nodes from an unknown primary site: Results of bilateral neck plus mucosal irradiation vs. ipsilateral neck irradiation. Int J Radiat Oncol Biol Phys 37: 797-802, 1997
15. Perkins SM, Spencer CR, Chernock RD, et al: Radiotherapeutic management of cervical lymph node metastases from an unknown primary site. Arch Otolaryngol Head Neck Surg 138: 656-661, 2012
16. Cuaron J, Rao S, Wolden S, et al: Patterns of failure in patients with head and neck carcinoma of unknown primary treated with radiation therapy. Head Neck 10.1002/hed.24013 [epub ahead of print on January 12, 2015]
17. Sher DJ, Balboni TA, Haddad RI, et al: Efficacy and toxicity of chemoradiotherapy using intensitymodulated radiotherapy for unknown primary of head and neck. Int J Radiat Oncol Biol Phys 80: 1405-1411, 2011
18. Marcial-Vega VA, Cardenes H, Perez CA, et al: Cervical metastases from unknown primaries: Radiotherapeutic management and appearance of subsequent primaries. Int J Radiat Oncol Biol Phys 19: 919-928, 1990
19. Sinnathamby K, Peters LJ, Laidlaw C, et al: The occult head and neck primary: To treat or not to treat? Clin Oncol (R Coll Radiol) 9: 322-329, 1997
20. Wallace A, Richards GM, Harari PM, et al: Head and neck squamous cell carcinoma from an unknown primary site. Am J Otolaryngol 32: 286-290, 2011
21. Cianchetti M, Mancuso AA, Amdur RJ, et al: Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope 119: 2348-2354, 2009
22. Koivunen P, Laranne J, Virtaniemi J, et al: Cervical metastasis of unknown origin: A series of 72 patients. Acta Otolaryngol 122: 569-574, 2002
23. Jones AS, Cook JA, Phillips DE, et al: Squamous carcinoma presenting as an enlarged cervical lymph node. Cancer 72: 1756-1761, 1993
24. Enepekides DJ: Management of congenital anomalies of the neck. Facial Plast Surg Clin North Am 9: 131-145, 2001
25. Goldenberg D, Begum S, Westra WH, et al: Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck 30: 898-903, 2008
26. Pincus R: Congenital neck masses and cysts, in Bailey BJ (ed): Head and Neck Surgery: Otolaryngology (ed 3). New York, NY, Lippincott Williams & Wilkins, 2001, p. 933
27. Zaifullah S, Yunus MR, See GB: Diagnosis and treatment of branchial cleft anomalies in UKMMC: A 10-year retrospective study. Eur Arch Otorhinolaryngol 270: 1501-1506, 2013
28. O'Sullivan B, Huang SH, Siu LL, et al: Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 31: 543-550, 2013
29. Beadle BM, William WN Jr, McLemore MS, et al: P16 expression in cutaneous squamous carcinomas with neck metastases: A potential pitfall in identifying unknown primaries of the head and neck. Head Neck 35: 1527-1533, 2013
30. Muraki AS, Mancuso AA, Harnsberger HR: Metastatic cervical adenopathy from tumors of unknown origin: The role of CT. Radiology 152: 749-753, 1984
31. Nakamoto Y, Tatsumi M, Hammoud D, et al: Normal FDG distribution patterns in the head and neck: PET/CT evaluation. Radiology 234: 879-885, 2005
32. Rusthoven KE, Koshy M, Paulino AC: The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. Cancer 101: 2641-2649, 2004
33. Johansen J, Buus S, Loft A, et al: Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor: Results from the DAHANCA-13 study. Head Neck 30: 471-478, 2008
34. Kim SH, Koo BS, Kang S, et al: HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int J Cancer 120: 1418-1425, 2007
35. Koch WM, Bhatti N, Williams MF, et al: Oncologic rationale for bilateral tonsillectomy in head and neck squamous cell carcinoma of unknown primary source. Otolaryngol Head Neck Surg 124: 331-333, 2001
36. Lee WY, Hsiao JR, Jin YT, et al: Epstein-Barr virus detection in neck metastases by in-situ hybridization in fine-needle aspiration cytologic studies: An aid for differentiating the primary site. Head Neck 22: 336-340, 2000
37. Chaturvedi AK, Engels EA, Pfeiffer RM, et al: Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29: 4294-4301, 2011
38. Begum S, Gillison ML, Nicol TL, et al: Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 13: 1186-1191, 2007
39. Waltonen JD, Ozer E, Schuller DE, et al: Tonsillectomy vs. deep tonsil biopsies in detecting occult tonsil tumors. Laryngoscope 119: 102-106, 2009
40. Waltonen JD, Ozer E, Hall NC, et al: Metastatic carcinoma of the neck of unknown primary origin: Evolution and efficacy of the modern workup. Arch Otolaryngol Head Neck Surg 135: 1024-1029, 2009
41. Cosmidis A, Rame JP, Dassonville O, et al: T1-T2 NO oropharyngeal cancers treated with surgery alone: A GETTEC study. Eur Arch Otorhinolaryngol 261: 276-281, 2004
42. O'Sullivan B, Warde P, Grice B, et al: The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region. Int J Radiat Oncol Biol Phys 51: 332-343, 2001
43. Hockstein NG, O'Malley BW Jr, Weinstein GS: Assessment of intraoperative safety in transoral robotic surgery. Laryngoscope 116: 165-168, 2006
44. Jackel MC, Martin A, Steiner W: Twenty-five years' experience with laser surgery for head and neck tumors: Report of an international symposium, Gottingen, Germany, 2005. Eur Arch Otorhinolaryngol 264: 577-585, 2007
45. Mehta V, Johnson P, Tassler A, et al: A new paradigm for the diagnosis and management of unknown primary tumors of the head and neck: A role for transoral robotic surgery. Laryngoscope 123: 146-151, 2013
46. Nagel TH, Hinni ML, Hayden RE, et al: Transoral laser microsurgery for the unknown primary: Role for lingual tonsillectomy. Head Neck 36: 942-946, 2014
47. Graboyes EM, Sinha P, Thorstad WL, et al: Management of human papillomavirus-related unknown primaries of the head and neck with a transoral surgical approach. Head Neck 10.1002/ hed.23800 [epub ahead of print on June 14, 2014]
48. Durmus K, Rangarajan SV, Old MO, et al: Transoral robotic approach to carcinoma of unknown primary. Head Neck 36: 848-852, 2014
49. Patel SA, Magnuson JS, Holsinger FC, et al: Robotic surgery for primary head and neck squamous cell carcinoma of unknown site. JAMA Otolaryngol Head Neck Surg 139: 1203-1211, 2013
50. Mork J, Lie AK, Glattre E, et al: Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344: 1125-1131, 2001
51. Desai PC, Jaglal MV, Gopal P, et al: Human papillomavirus in metastatic squamous carcinoma from unknown primaries in the head and neck: A retrospective 7 year study. Exp Mol Pathol 87: 94-98, 2009
52. Compton AM, Moore-Medlin T, Herman- Ferdinandez L, et al: Human papillomavirus in metastatic lymph nodes from unknown primary head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 145: 51-57, 2011
53. Parsons JT, Mendenhall WM, Stringer SP, et al: Squamous cell carcinoma of the oropharynx: Surgery, radiation therapy, or both. Cancer 94: 2967-2980, 2002
54. Coker DD, Casterline PF, Chambers RG, et al: Metastases to lymph nodes of the head and neck from an unknown primary site. Am J Surg 134: 517-522, 1977
55. Coster JR, Foote RL, Olsen KD, et al: Cervical nodal metastasis of squamous cell carcinoma of unknown origin: Indications for withholding radiation therapy. Int J Radiat Oncol Biol Phys 23: 743-749, 1992
56. Ebrahimi A, Gil Z, Amit M, et al: A comparison of the American Joint Committee on Cancer N1 versus N2a nodal categories for predicting survival and recurrence in patients with oral cancer: Time to acknowledge an arbitrary distinction and modify the system. Head Neck 10.1002/hed.23871 [epub ahead of print on September 16, 2014]
57. Million RR CN, Mancuso AAL: The unknown primary, in Million RR, Cassisi NJ (eds). Management of Head and Neck Cancer: A Multidisciplinary Approach (ed 2). Philadelphia, PA, Lippincott, 1994, pp. 311-320
58. Barker CA, Morris CG, Mendenhall WM: Larynx-sparing radiotherapy for squamous cell carcinoma from an unknown head and neck primary site. Am J Clin Oncol 28: 445-448, 2005
59. Glynne-Jones RG, Anand AK, Young TE, et al: Metastatic carcinoma in the cervical lymph nodes from an occult primary: A conservative approach to the role of radiotherapy. Int J Radiat Oncol Biol Phys 18: 289-294, 1990
60. Weir L, Keane T, Cummings B, et al: Radiation treatment of cervical lymph node metastases from an unknown primary: An analysis of outcome by treatment volume and other prognostic factors. Radiother Oncol 35: 206-211, 1995
61. Mourad WF, Hu KS, Shasha D, et al: Initial experience with oropharynx-targeted radiation therapy for metastatic squamous cell carcinoma of unknown primary of the head and neck. Anticancer Res 34: 243-248, 2014
62. Fakhry C, Westra WH, Li S, et al: Improved survival of patients with human papillomaviruspositive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100: 261-269, 2008
63. Chung CH, Zhang Q, Kong CS, et al: P16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma. J Clin Oncol, 2014
64. Gregoire V, Ang K, Budach W, et al: Delineation of the neck node levels for head and neck tumors: A 2013 update-DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 110: 172-181, 2014
65. Adelstein DJ, Li Y, Adams GL, et al: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21: 92-98, 2003
66. Forastiere AA, Metch B, Schuller DE, et al: Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: A Southwest Oncology Group study. J Clin Oncol 10: 1245-1251, 1992
67. Garden AS, Asper JA, Morrison WH, et al: Is concurrent chemoradiation the treatment of choice for all patients with stage III or IV head and neck carcinoma? Cancer 100: 1171-1178, 2004
68. Cooper JS, Pajak TF, Forastiere AA, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350: 1937-1944, 2004
69. Trotti A, Pajak TF, Gwede CK, et al: TAME: Development of a new method for summarising adverse events of cancer treatment by the Radiation Therapy Oncology Group. Lancet Oncol 8: 613-624, 2007
70. Sinha P, Lewis JS Jr, Piccirillo JF, et al: Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer 118: 3519-3530, 2012