Efficacy and toxicity of chemoradiotherapy using intensity-modulated radiotherapy for unknown primary of head and neck

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 5, 2011, Pages 1405-1411

  Sher, David J ^a   Balboni, Tracy A ^a   Haddad, Robert I ^a,b   Norris Jr , Charles M ^a   Posner, Marshall R ^a,b   Wirth, Lori J ^c   Goguen, Laura A ^a   Annino, Donald ^a   Tishler, Roy B ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Combined modality therapy; Head and neck cancer; IMRT; Intensity modulated radiotherapy; Unknown primary

Indexed keywords

COMBINED MODALITY THERAPY; HEAD-AND-NECK CANCER; IMRT; INTENSITY-MODULATED RADIOTHERAPY; UNKNOWN PRIMARY;

CHEMOTHERAPY; COMPUTERIZED TOMOGRAPHY; DISEASES; PATIENT MONITORING; POSITRON EMISSION TOMOGRAPHY; RADIOTHERAPY; TOXICITY;

PHYSICAL THERAPY;

CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; FLUOROURACIL; PACLITAXEL; PLATINUM DERIVATIVE; TAXANE DERIVATIVE;

ACUTE TOXICITY; ADULT; AGED; ANESTHESIA; ARTICLE; CANCER CONTROL; CANCER OF UNKNOWN PRIMARY SITE; CANCER STAGING; CANCER SURVIVAL; CHEMORADIOTHERAPY; CHRONIC TOXICITY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; ESOPHAGUS DILATATION; ESOPHAGUS STRICTURE; FEMALE; FOLLOW UP; HEAD AND NECK CARCINOMA; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MALE; NECK DISSECTION; OVERALL SURVIVAL; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; XEROSTOMIA;

AGED; BOSTON; CANCER CARE FACILITIES; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; ESOPHAGEAL STENOSIS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOPLASMS, UNKNOWN PRIMARY; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; XEROSTOMIA;

EID: 79960094407     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.04.029     Document Type: Article

References (25)

1. J.D. Waltonen, E. Ozer, and N.C. Hall Metastatic carcinoma of the neck of unknown primary origin: Evolution and efficacy of the modern workup Arch Otolaryngol Head Neck Surg 135 2009 1024 1029
2. F.R. Miller, A.B. Karnad, and T. Eng Management of the unknown primary carcinoma: Long-term follow-up on a negative PET scan and negative panendoscopy Head Neck 30 2008 28 34 (Pubitemid 351158318)
3. L. Calabrese, B.A. Jereczek-Fossa, and J. Jassem Diagnosis and management of neck metastases from an unknown primary Acta Otorhinolaryngol Ital 25 2005 2 12
4. H.S. Erkal, W.M. Mendenhall, and R.J. Amdur Squamous cell carcinomas metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with neck dissection Int J Radiat Oncol Biol Phys 50 2001 55 63
5. S. Bhide, C. Clark, and K. Harrington Intensity modulated radiotherapy improves target coverage and parotid gland sparing when delivering total mucosal irradiation in patients with squamous cell carcinoma of head and neck of unknown primary site Med Dosim 32 2007 188 195 (Pubitemid 47239420)
6. I. Madani, L. Vakaet, and K. Bonte Intensity-modulated radiotherapy for cervical lymph node metastases from unknown primary cancer Int J Radiat Oncol Biol Phys 71 2008 1158 1166
7. H. Lu, M. Yao, and H. Tan Unknown primary head and neck cancer treated with intensity-modulated radiation therapy: To what extent the volume should be irradiated Oral Oncol 45 2009 474 479
8. M.L. Klem, J.G. Mechalakos, and S.L. Wolden Intensity-modulated radiotherapy for head and neck cancer of unknown primary: Toxicity and preliminary efficacy Int J Radiat Oncol Biol Phys 70 2008 1100 1107 (Pubitemid 351296099)
9. C.A. Murdoch-Kinch, H.M. Kim, and K.A. Vineberg Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy Int J Radiat Oncol Biol Phys 72 2008 373 382
10. National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4. Bethesda: National Cancer Institute. Available at http://ctep.cancer.gov/protocolDevelopment/electronic-applications/ctc.htm. Accessed June 25, 2010.
11. A.M. Chen, B.Q. Li, and R.L. Jennelle Late esophageal toxicity after radiation therapy for head and neck cancer Head Neck 32 2010 178 183
12. J.D. Lawson, K. Otto, and W. Grist Frequency of esophageal stenosis after simultaneous modulated accelerated radiation therapy and chemotherapy for head and neck cancer Am J Otolaryngol 29 2008 13 19 (Pubitemid 350180153)
13. A. Ahlberg, M. Al-Abany, and E. Alevronta Esophageal stricture after radiotherapy in patients with head and neck cancer: Experience of a single institution over 2 treatment periods Head Neck 32 2010 452 461
14. T.M. Mekhail, D.J. Adelstein, and L.A. Rybicki Enteral nutrition during the treatment of head and neck carcinoma: Is a percutaneous endoscopic gastrostomy tube preferable to a nasogastric tube? Cancer 91 2001 1785 1790 (Pubitemid 32377965)
15. S. Iganej, R. Kagan, and P. Anderson Metastatic squamous cell carcinoma of the neck from an unknown primary: Management options and patterns of relapse Head Neck 24 2002 236 246 (Pubitemid 34193248)
16. C. Grau, L.V. Johansen, and J. Jakobsen Cervical lymph node metastases from unknown primary tumours: Results from a national survey by the Danish Society for Head and Neck Oncology Radiother Oncol 55 2000 121 129 (Pubitemid 30229986)
17. C. Nieder, V. Gregoire, and K.K. Ang Cervical lymph node metastases from occult squamous cell carcinoma: Cut down a tree to get an apple? Int J Radiat Oncol Biol Phys 50 2001 727 733 (Pubitemid 32515327)
18. W.M. Mendenhall, A.A. Mancuso, and R.J. Amdur Squamous cell carcinoma metastatic to the neck from an unknown head and neck primary site Am J Otolaryngol 22 2001 261 267 (Pubitemid 32718041)
19. C.A. Barker, C.G. Morris, and W.M. Mendenhall Larynx-sparing radiotherapy for squamous cell carcinoma from an unknown head and neck primary site Am J Clin Oncol 28 2005 445 448 (Pubitemid 41437380)
20. J. Mork, A.K. Lie, and E. Glattre Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck N Engl J Med 344 2001 1125 1131 (Pubitemid 32285233)
21. G. D'Souza, A.R. Kreimer, and R. Viscidi Case-control study of human papillomavirus and oropharyngeal cancer N Engl J Med 356 2007 1944 1956 (Pubitemid 46740304)
22. McGovern SL, Williams MD, Weber RS, et al. Three synchronous HPV-associated squamous cell carcinomas of Waldeyer's ring: Case report and comparison with Slaughter's model of field cancerization. Head Neck Epub 2009 Jul 1.
23. J.H. Maxwell, B. Kumar, and F.Y. Feng HPV-positive/p16-positive/EBV- negative nasopharyngeal carcinoma in white North Americans Head Neck Epub 2009 Sept 15
24. M.L. Gillison, G. D'Souza, and W. Westra Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers J Natl Cancer Inst 100 2008 407 420 (Pubitemid 351480511)
25. G. Bozdayi, Y. Kemaloglu, and O. Ekinci Role of human papillomavirus in the clinical and histopathologic features of laryngeal and hypopharyngeal cancers J Otolaryngol Head Neck Surg 38 2009 119 125