New data shed light on Y-loss-related pathogenesis in myelodysplastic syndromes

Genes Chromosomes and Cancer

Volumn 54, Issue 12, 2015, Pages 717-724

  Ganster, Christina ^a   Kämpfe, Dietrich ^b   Jung, Klaus ^a   Braulke, Friederike ^a   Shirneshan, Katayoon ^a   Machherndl Spandl, Sigrid ^c   Suessner, Susanne ^d   Bramlage, Carsten P ^a   Legler, Tobias J ^a   Koziolek, Michael J ^a   Haase, Detlef ^a   Schanz, Julie ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b Praxis für Hämatologie und Onkologie   (Germany)

^c ELISABETHINEN HOSPITAL   (Austria)

^d Austrian Cluster for Tissue Regeneration   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD CELL; BLOOD DONOR; CD3+ T LYMPHOCYTE; CHROMOSOME LOSS; CLINICAL ARTICLE; CLONAL CELL LINE; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; VERY ELDERLY; Y CHROMOSOME; ANTIGEN MEDIATED CLONAL SELECTION; CELL CULTURE; CHROMOSOME DELETION; GENETICS; IMMUNOLOGY; METABOLISM; T LYMPHOCYTE; YOUNG ADULT;

CD3 ANTIGEN; CD34 ANTIGEN;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; ANTIGENS, CD34; BLOOD DONORS; CELLS, CULTURED; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, Y; CLONAL SELECTION, ANTIGEN-MEDIATED; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84944244310     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.22282     Document Type: Article

References (22)

1. Boultwood J, Wainscoat JS. 2001. Clonality in the myelodysplastic syndromes. Int J Hematol 73:411-415.
2. Braulke F, Schanz J, Jung K, Shirneshan K, Schulte K, Schütze C, Steffens R, Trümper L, Haase D. 2010. FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: Verification of the method and application to 27 MDS patients. Leuk Res 34:1296-1301.
3. Braulke F, Jung K, Schanz J, Götze K, Müller-Thomas C, Platzbecker U, Germing U, Brümmendorf T, Bug G, Ottmann O, Giagounidis A, Stadler M, Hofmann W, Schafhausen P, Lübbert M, Schlenk R, Blau I, Ganster C, Pfeifer S, Shirneshan K, Metz M, Detken S, Seraphin J, Jentsch-Ullrich K, Böhme A, Schmidt B, Trümper L, Haase D. 2013. Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes-First results from a prospective multicenter German diagnostic study. Leuk Res 37:900-906.
4. Braulke F, Platzbecker U, Müller-Thomas C, Götze K, Germing U, Brümmendorf TH, Nolte F, Hofmann WK, Giagounidis AA, Lübbert M, Greenberg PL, Bennett JM, Sole F, Mallo M, Slovak ML, Ohyashiki K, Le Beau MM, Tüchler H, Pfeilstöcker M, Nösslinger T, Hildebrandt B, Shirneshan K, Aul C, Stauder R, Sperr WR, Valent P, Fonatsch C, Trümper L, Haase D, Schanz J. 2015. Validation of cytogenetic risk groups according to International Prognostic Scoring Systems by peripheral blood CD34+FISH: Results from a German diagnostic study in comparison with an international control group. Haematologica 100:205-213.
5. Chapiro E, Antony-Debre I, Marchay N, Parizot C, Lesty C, Cung HA, Mathis S, Grelier A, Maloum K, Choquet S, Azgui Z, Uzunov M, Leblond V, Merle-Beral H, Sutton L, Davi F, Nguyen-Khac F. 2014. Sex chromosome loss may represent a disease-associated clonal population in chronic lymphocytic leukemia. Genes Chromosomes Cancer 53:240-247.
6. Forsberg LA, Rasi C, Razzaghian HR, Pakalapati G, Waite L, Thilbeault KS, Ronowicz A, Wineinger NE, Tiwari HK, Boomsma D, Westerman MP, Harris JR, Lyle R, Essand M, Eriksson F, Assimes TL, Iribarren C, Strachan E, O'Hanlon TP, Rider LG, Miller FW, Giedraitis V, Lannfelt L, Ingelsson M, Piotrowski A, Pedersen NL, Absher D Dumanski JP. 2012. Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet 90:217-228.
7. Forsberg LA, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, Sandgren J, Diaz de Stahl T, Zaghlool A, Giedraitis V, Lannfelt L, Score J, Cross NC, Absher D, Janson ET, Lindgren CM, Morris AP, Ingelsson E, Lind L Dumanski JP. 2014. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet 46:624-628.
8. Genovese G, Kahler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landen M, Hoglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Gronberg H, Hultman CM, McCarroll SA. 2014. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med 371:2477-2487.
9. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J. 1997. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 89:2079-2088.
10. Haase D, Feuring-Buske M, Konemann S, Fonatsch C, Troff C, Verbeek W, Pekrun A, Hiddemann W, Wormann B. 1995. Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations. Blood 86:2906-2912.
11. Haase D, Germing U, Schanz J, Pfeilstöcker M, Nösslinger T, Hildebrandt B, Kündgen A, Lübbert M, Kunzmann R, Giagounidis AA, Aul C, Trümper L, Krieger O, Stauder R, Müller TH, Wimazal F, Valent P, Fonatsch C, Steidl C. 2007. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: Evidence from a core dataset of 2124 patients. Blood 110:4385-4395.
12. Herens C, Brasseur E, Jamar M, Vierset L, Schoenen I, Koulischer L. 1999. Loss of the Y chromosome in bone marrow cells: Results on 1907 consecutive cases of leukaemia and preleukaemia. Clin Lab Haematol 21:17-20.
13. Jacobs KB, Yeager M, Zhou W, Wacholder S, Wang Z, Rodriguez-Santiago B, Hutchinson A, Deng X, Liu C, Horner MJ, Cullen M, Epstein CG, Burdett L, Dean MC, Chatterjee N, Sampson J, Chung CC, Kovaks J, Gapstur SM, Stevens VL, Teras LT, Gaudet MM, Albanes D, Weinstein SJ, Virtamo J, Taylor PR, Freedman ND, Abnet CC, Goldstein AM, Hu N, Yu K, Yuan JM, Liao L, Ding T, Qiao YL, Gao YT, Koh WP, Xiang YB, Tang ZZ, Fan JH, Aldrich MC, Amos C, Blot WJ, Bock CH, Gillanders EM, Harris CC, Haiman CA, Henderson BE, Kolonel LN, Marchand McNeill LL, Rybicki LH, Schwartz BA, Signorello AG, Spitz LB, Wiencke MR, Wrensch JK, Wu M, Zanetti X, Ziegler KA, Figueroa RG, Garcia-Closas JD, Malats M, Marenne N, Prokunina-Olsson G, Baris L, Schwenn D, Johnson M, Landi A, Goldin MT, Consonni L, Bertazzi D, Rotunno PA, Rajaraman M, Andersson P, Beane Freeman U, Berg LE, Buring CD, Butler JE, Carreon MA, Feychting T, Ahlbom M, Gaziano A, Giles JM, Hallmans GG, Hankinson G, Hartge SE, Henriksson P, Inskip R, Johansen PD, Landgren C, McKean-Cowdin A, Michaud R, Melin DS, Peters BS, Ruder U, Sesso AM, Severi HD, Shu G, Visvanathan XO, White K, Wolk E, Zeleniuch-Jacquotte A, Zheng A, Silverman W, Kogevinas DT, Gonzalez M, Villa JR, Li O, Duell D, Risch EJ, Olson HA, Kooperberg SH, Wolpin C, Jiao BM, Hassan L, Wheeler M, Arslan W, Bueno-de-Mesquita AA, Fuchs HB, Gallinger CS, Gross S, Holly MD, Klein EA, LaCroix AP, Mandelson A, Petersen MT, Boutron-Ruault G, Bracci MC, Canzian PM, Chang F, Cotterchio K, Giovannucci M, Goggins EL, Hoffman Bolton M, Jenab JA, Khaw M, Krogh KT, Kurtz V, McWilliams RC, Mendelsohn RR, Rabe JB, Riboli KG, Tjonneland E, Tobias A, Trichopoulos GS, Elena D, Yu JW, Amundadottir H, Stolzenberg-Solomon L, Kraft RZ, Schumacher P, Stram F, Savage D, Mirabello SA, Andrulis L, Wunder IL, Patino Garcia JS, Sierrasesumaga A, Barkauskas L, Gorlick DA, Purdue RG, Chow M, Moore WH, Schwartz LE, Davis KL, Hsing FG, Berndt AW, Black SI, Wentzensen A, Brinton N, Lissowska LA, Peplonska J, McGlynn B, Cook KA, Graubard MB, Kratz BI, Greene CP, Erickson MH, Hunter RL, Thomas DJ, Hoover G, Real RN, Fraumeni FX, Caporaso JF Jr, Tucker NE, Rothman M, Perez-Jurado N, Chanock LASJ. 2012. Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet 44:651-658.
14. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL. 2014. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med 371:2488-2498.
15. Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, Muller M, 2011. pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform 12:77.
16. Schanz J, Tüchler H, Sole F, Mallo M, Luno E, Cervera J, Granada I, Hildebrandt B, Slovak ML, Ohyashiki K, Steidl C, Fonatsch C, Pfeilstöcker M, Nösslinger T, Valent P, Giagounidis A, Aul C, Lübbert M, Stauder R, Krieger O, Garcia-Manero G, Faderl S, Pierce S, Le Beau MM, Bennett JM, Greenberg P, Germing U, Haase D. 2012. New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge. J Clin Oncol 30:820-829.
17. Stone JF, Sandberg AA. 1995. Sex chromosome aneuploidy and aging. Mutat Res 338:107-113.
18. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992. Loss of the Y chromosome from normal and neoplastic bone marrows. Genes Chromosomes Cancer 5:83-88.
19. Vehmeyer K, Haase D, Alves F. 2001. Increased peripheral stem cell pool in MDS: An indication of disease progression? Leuk Res 25:955-959.
20. Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL. 2000. Clinical significance of Y chromosome loss in hematologic disease. Genes Chromosomes Cancer 27:11-16.
21. Wiktor AE, Van Dyke DL, Hodnefield JM, Eckel-Passow J, Hanson CA. 2011. The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years. Leuk Res 35:1297-1300.
22. Wong AK, Fang B, Zhang L, Guo XQ, Lee S, Schreck R. 2008. Loss of the Y chromosome-An age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome? Arch Pathol Lab Med 132:1329-1332.