메뉴 건너뛰기




Volumn 17, Issue 7, 2015, Pages 885-896

Mesenchymal stromal cell delivery of full-length tumor necrosis factor-related apoptosis-inducing ligand is superior to soluble type for cancer therapy

Author keywords

Apoptosis; Cancer; Mesenchymal stromal cell; TRAIL; Tumor

Indexed keywords

ANTINEOPLASTIC AGENT; FULL LENGTH HUMAN TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; LENTIVIRUS VECTOR; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 84944197204     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2015.03.603     Document Type: Article
Times cited : (53)

References (60)
  • 1
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley S.R., Schooley K., Smolak P.J., Din W.S., Huang C.P., Nicholl J.K., et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995, 3:673-682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1    Schooley, K.2    Smolak, P.J.3    Din, W.S.4    Huang, C.P.5    Nicholl, J.K.6
  • 2
    • 17544367410 scopus 로고    scopus 로고
    • Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
    • Pitti R.M., Marsters S.A., Ruppert S., Donahue C.J., Moore A., Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 1996, 271:12687-12690.
    • (1996) J Biol Chem , vol.271 , pp. 12687-12690
    • Pitti, R.M.1    Marsters, S.A.2    Ruppert, S.3    Donahue, C.J.4    Moore, A.5    Ashkenazi, A.6
  • 3
    • 84893865759 scopus 로고    scopus 로고
    • Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
    • Lemke J., von Karstedt S., Abd El Hay M., Conti A., Arce F., Montinaro A., et al. Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1. Cell Death Differ 2014, 21:491-502.
    • (2014) Cell Death Differ , vol.21 , pp. 491-502
    • Lemke, J.1    von Karstedt, S.2    Abd El Hay, M.3    Conti, A.4    Arce, F.5    Montinaro, A.6
  • 4
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H., Miller R.E., Ariail K., Gliniak B., Griffith T.S., Kubin M., et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999, 5:157-163.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3    Gliniak, B.4    Griffith, T.S.5    Kubin, M.6
  • 6
    • 32444443192 scopus 로고    scopus 로고
    • Cancer gene therapy using a novel secretable trimeric TRAIL
    • Kim C.Y., Jeong M., Mushiake H., Kim B.M., Kim W.B., Ko J.P., et al. Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther 2006, 13:330-338.
    • (2006) Gene Ther , vol.13 , pp. 330-338
    • Kim, C.Y.1    Jeong, M.2    Mushiake, H.3    Kim, B.M.4    Kim, W.B.5    Ko, J.P.6
  • 7
    • 50349092260 scopus 로고    scopus 로고
    • A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
    • Hotte S.J., Hirte H.W., Chen E.X., Siu L.L., Le L.H., Corey A., et al. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clin Cancer Res 2008, 14:3450-3455.
    • (2008) Clin Cancer Res , vol.14 , pp. 3450-3455
    • Hotte, S.J.1    Hirte, H.W.2    Chen, E.X.3    Siu, L.L.4    Le, L.H.5    Corey, A.6
  • 8
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
    • Greco F.A., Bonomi P., Crawford J., Kelly K., Oh Y., Halpern W., et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008, 61:82-90.
    • (2008) Lung Cancer , vol.61 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3    Kelly, K.4    Oh, Y.5    Halpern, W.6
  • 9
    • 84881338743 scopus 로고    scopus 로고
    • Death receptors as targets in cancer
    • Micheau O., Shirley S., Dufour F. Death receptors as targets in cancer. Br J Pharmacol 2013, 169:1723-1744.
    • (2013) Br J Pharmacol , vol.169 , pp. 1723-1744
    • Micheau, O.1    Shirley, S.2    Dufour, F.3
  • 10
    • 66249083525 scopus 로고    scopus 로고
    • Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer
    • Loebinger M.R., Eddaoudi A., Davies D., Janes S.M. Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer. Cancer Res 2009, 69:4134-4142.
    • (2009) Cancer Res , vol.69 , pp. 4134-4142
    • Loebinger, M.R.1    Eddaoudi, A.2    Davies, D.3    Janes, S.M.4
  • 11
    • 56249091888 scopus 로고    scopus 로고
    • Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model
    • Mohr A., Lyons M., Deedigan L., Harte T., Shaw G., Howard L., et al. Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model. J Cell Mol Med 2008, 12:2628-2643.
    • (2008) J Cell Mol Med , vol.12 , pp. 2628-2643
    • Mohr, A.1    Lyons, M.2    Deedigan, L.3    Harte, T.4    Shaw, G.5    Howard, L.6
  • 12
    • 57149088465 scopus 로고    scopus 로고
    • Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma
    • Kim S.M., Lim J.Y., Park S.I., Jeong C.H., Oh J.H., Jeong M., et al. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Cancer Res 2008, 68:9614-9623.
    • (2008) Cancer Res , vol.68 , pp. 9614-9623
    • Kim, S.M.1    Lim, J.Y.2    Park, S.I.3    Jeong, C.H.4    Oh, J.H.5    Jeong, M.6
  • 13
    • 84902285618 scopus 로고    scopus 로고
    • Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma
    • Sage E.K., Kolluri K.K., McNulty K., Lourenco Sda S., Kalber T.L., Ordidge K.L., et al. Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma. Thorax 2014, 69:638-647.
    • (2014) Thorax , vol.69 , pp. 638-647
    • Sage, E.K.1    Kolluri, K.K.2    McNulty, K.3    Lourenco Sda, S.4    Kalber, T.L.5    Ordidge, K.L.6
  • 14
    • 84886302561 scopus 로고    scopus 로고
    • Signaling molecules and pathways involved in MSC tumor tropism
    • Ho I.A., Lam P.Y. Signaling molecules and pathways involved in MSC tumor tropism. Histol Histopathol 2013, 28:1427-1438.
    • (2013) Histol Histopathol , vol.28 , pp. 1427-1438
    • Ho, I.A.1    Lam, P.Y.2
  • 15
    • 84897903956 scopus 로고    scopus 로고
    • Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration
    • Yang Z.S., Tang X.J., Guo X.R., Zou D.D., Sun X.Y., Feng J.B., et al. Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration. Onco Targets Ther 2014, 7:441-446.
    • (2014) Onco Targets Ther , vol.7 , pp. 441-446
    • Yang, Z.S.1    Tang, X.J.2    Guo, X.R.3    Zou, D.D.4    Sun, X.Y.5    Feng, J.B.6
  • 16
    • 84895528244 scopus 로고    scopus 로고
    • EMT and acquisition of stem cell-like properties are involved in spontaneous formation of tumorigenic hybrids between lung cancer and bone marrow-derived mesenchymal stem cells
    • Xu M.H., Gao X., Luo D., Zhou X.D., Xiong W., Liu G.X. EMT and acquisition of stem cell-like properties are involved in spontaneous formation of tumorigenic hybrids between lung cancer and bone marrow-derived mesenchymal stem cells. PLoS One 2014, 9:e87893.
    • (2014) PLoS One , vol.9 , pp. e87893
    • Xu, M.H.1    Gao, X.2    Luo, D.3    Zhou, X.D.4    Xiong, W.5    Liu, G.X.6
  • 17
    • 55249121401 scopus 로고    scopus 로고
    • Imaging mesenchymal stem cell migration and the implications for stem cell-based cancer therapies
    • Wang H., Chen X. Imaging mesenchymal stem cell migration and the implications for stem cell-based cancer therapies. Future Oncol 2008, 4:623-628.
    • (2008) Future Oncol , vol.4 , pp. 623-628
    • Wang, H.1    Chen, X.2
  • 18
    • 84878504643 scopus 로고    scopus 로고
    • Mesenchymal Stem Cells as Vectors for Lung Cancer Therapy
    • Kolluri K.K., Laurent G.J., Janes S.M. Mesenchymal Stem Cells as Vectors for Lung Cancer Therapy. Respiration 2013, 85:443-451.
    • (2013) Respiration , vol.85 , pp. 443-451
    • Kolluri, K.K.1    Laurent, G.J.2    Janes, S.M.3
  • 19
    • 7944220831 scopus 로고    scopus 로고
    • Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents
    • Studeny M., Marini F.C., Dembinski J.L., Zompetta C., Cabreira-Hansen M., Bekele B.N., et al. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004, 96:1593-1603.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1593-1603
    • Studeny, M.1    Marini, F.C.2    Dembinski, J.L.3    Zompetta, C.4    Cabreira-Hansen, M.5    Bekele, B.N.6
  • 20
    • 34547167177 scopus 로고    scopus 로고
    • Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells
    • Xin H., Kanehira M., Mizuguchi H., Hayakawa T., Kikuchi T., Nukiwa T., et al. Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells 2007, 25:1618-1626.
    • (2007) Stem Cells , vol.25 , pp. 1618-1626
    • Xin, H.1    Kanehira, M.2    Mizuguchi, H.3    Hayakawa, T.4    Kikuchi, T.5    Nukiwa, T.6
  • 21
    • 33646690027 scopus 로고    scopus 로고
    • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    • Khakoo A.Y., Pati S., Anderson S.A., Reid W., Elshal M.F., Rovira, et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2006, 203:1235-1247.
    • (2006) J Exp Med , vol.203 , pp. 1235-1247
    • Khakoo, A.Y.1    Pati, S.2    Anderson, S.A.3    Reid, W.4    Elshal, M.F.5    Rovira6
  • 22
    • 33846908513 scopus 로고    scopus 로고
    • Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells
    • Menon L.G., Picinich S., Koneru R., Gao H., Lin S.Y., Koneru M., et al. Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells. Stem Cells 2007, 25:520-528.
    • (2007) Stem Cells , vol.25 , pp. 520-528
    • Menon, L.G.1    Picinich, S.2    Koneru, R.3    Gao, H.4    Lin, S.Y.5    Koneru, M.6
  • 23
    • 68149181527 scopus 로고    scopus 로고
    • Applications of neural and mesenchymal stem cells in the treatment of gliomas
    • Kosztowski T., Zaidi H.A., Quinones-Hinojosa A. Applications of neural and mesenchymal stem cells in the treatment of gliomas. Expert Rev Anticancer Ther 2009, 9:597-612.
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 597-612
    • Kosztowski, T.1    Zaidi, H.A.2    Quinones-Hinojosa, A.3
  • 25
    • 20244374417 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    • Nakamizo A., Marini F., Amano T., Khan A., Studeny M., Gumin J., et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005, 65:3307-3318.
    • (2005) Cancer Res , vol.65 , pp. 3307-3318
    • Nakamizo, A.1    Marini, F.2    Amano, T.3    Khan, A.4    Studeny, M.5    Gumin, J.6
  • 26
    • 84875970163 scopus 로고    scopus 로고
    • Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects
    • Yu R., Deedigan L., Albarenque S.M., Mohr A., Zwacka R.M. Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects. Cell Death Dis 2013, 4:e503.
    • (2013) Cell Death Dis , vol.4 , pp. e503
    • Yu, R.1    Deedigan, L.2    Albarenque, S.M.3    Mohr, A.4    Zwacka, R.M.5
  • 27
    • 78649822978 scopus 로고    scopus 로고
    • Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells
    • Mohr A., Albarenque S.M., Deedigan L., Yu R., Reidy M., Fulda S., et al. Targeting of XIAP combined with systemic mesenchymal stem cell-mediated delivery of sTRAIL ligand inhibits metastatic growth of pancreatic carcinoma cells. Stem Cells 2010, 28:2109-2120.
    • (2010) Stem Cells , vol.28 , pp. 2109-2120
    • Mohr, A.1    Albarenque, S.M.2    Deedigan, L.3    Yu, R.4    Reidy, M.5    Fulda, S.6
  • 28
    • 78650918644 scopus 로고    scopus 로고
    • Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells
    • Santilli G., Almarza E., Brendel C., Choi U., Beilin C., Blundell M.P., et al. Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells. Mol Ther 2011, 19:122-132.
    • (2011) Mol Ther , vol.19 , pp. 122-132
    • Santilli, G.1    Almarza, E.2    Brendel, C.3    Choi, U.4    Beilin, C.5    Blundell, M.P.6
  • 29
    • 0022371467 scopus 로고
    • A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
    • Boshart M., Weber F., Jahn G., Dorsch-Hasler K., Fleckenstein B., Schaffner W. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 1985, 41:521-530.
    • (1985) Cell , vol.41 , pp. 521-530
    • Boshart, M.1    Weber, F.2    Jahn, G.3    Dorsch-Hasler, K.4    Fleckenstein, B.5    Schaffner, W.6
  • 30
    • 0031793228 scopus 로고    scopus 로고
    • An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution
    • Suzuki K., Hiroaki H., Kohda D., Tanaka T. An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution. Protein Eng 1998, 11:1051-1055.
    • (1998) Protein Eng , vol.11 , pp. 1051-1055
    • Suzuki, K.1    Hiroaki, H.2    Kohda, D.3    Tanaka, T.4
  • 31
    • 0026654187 scopus 로고
    • Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction
    • Coloma M.J., Hastings A., Wims L.A., Morrison S.L. Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction. J Immunol Methods 1992, 152:89-104.
    • (1992) J Immunol Methods , vol.152 , pp. 89-104
    • Coloma, M.J.1    Hastings, A.2    Wims, L.A.3    Morrison, S.L.4
  • 32
    • 77951952760 scopus 로고    scopus 로고
    • Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow
    • Qian S.W., Li X., Zhang Y.Y., Huang H.Y., Liu Y., Sun X., et al. Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Dev Biol 2010, 10:47.
    • (2010) BMC Dev Biol , vol.10 , pp. 47
    • Qian, S.W.1    Li, X.2    Zhang, Y.Y.3    Huang, H.Y.4    Liu, Y.5    Sun, X.6
  • 33
    • 84860140464 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension
    • Wang Y.K., Yu X., Cohen D.M., Wozniak M.A., Yang M.T., Gao L., et al. Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cells Dev 2012, 21:1176-1186.
    • (2012) Stem Cells Dev , vol.21 , pp. 1176-1186
    • Wang, Y.K.1    Yu, X.2    Cohen, D.M.3    Wozniak, M.A.4    Yang, M.T.5    Gao, L.6
  • 34
    • 77955536848 scopus 로고    scopus 로고
    • EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells
    • Curtis K.M., Gomez L.A., Rios C., Garbayo E., Raval A.P., Perez-Pinzon M.A., et al. EF1alpha and RPL13a represent normalization genes suitable for RT-qPCR analysis of bone marrow derived mesenchymal stem cells. BMC Mol Biol 2010, 11:61.
    • (2010) BMC Mol Biol , vol.11 , pp. 61
    • Curtis, K.M.1    Gomez, L.A.2    Rios, C.3    Garbayo, E.4    Raval, A.P.5    Perez-Pinzon, M.A.6
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 0035892735 scopus 로고    scopus 로고
    • Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells
    • Monleon I., Martinez-Lorenzo M.J., Monteagudo L., Lasierra P., Taules M., Iturralde M., et al. Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells. J Immunol 2001, 167:6736-6744.
    • (2001) J Immunol , vol.167 , pp. 6736-6744
    • Monleon, I.1    Martinez-Lorenzo, M.J.2    Monteagudo, L.3    Lasierra, P.4    Taules, M.5    Iturralde, M.6
  • 37
    • 0033662433 scopus 로고    scopus 로고
    • Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
    • Kischkel F.C., Lawrence D.A., Chuntharapai A., Schow P., Kim K.J., Ashkenazi A. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000, 12:611-620.
    • (2000) Immunity , vol.12 , pp. 611-620
    • Kischkel, F.C.1    Lawrence, D.A.2    Chuntharapai, A.3    Schow, P.4    Kim, K.J.5    Ashkenazi, A.6
  • 38
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector
    • Barde I., Zanta-Boussif M.A., Paisant S., Leboeuf M., Rameau P., Delenda C., et al. Efficient control of gene expression in the hematopoietic system using a single Tet-on inducible lentiviral vector. Mol Ther 2006, 13:382-390.
    • (2006) Mol Ther , vol.13 , pp. 382-390
    • Barde, I.1    Zanta-Boussif, M.A.2    Paisant, S.3    Leboeuf, M.4    Rameau, P.5    Delenda, C.6
  • 39
    • 41149159755 scopus 로고    scopus 로고
    • A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs
    • Chen X., Lin X., Zhao J., Shi W., Zhang H., Wang Y., et al. A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs. Mol Ther 2008, 16:749-756.
    • (2008) Mol Ther , vol.16 , pp. 749-756
    • Chen, X.1    Lin, X.2    Zhao, J.3    Shi, W.4    Zhang, H.5    Wang, Y.6
  • 40
    • 77649185403 scopus 로고    scopus 로고
    • Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma
    • Gao P., Ding Q., Wu Z., Jiang H., Fang Z. Therapeutic potential of human mesenchymal stem cells producing IL-12 in a mouse xenograft model of renal cell carcinoma. Cancer Lett 2010, 290:157-166.
    • (2010) Cancer Lett , vol.290 , pp. 157-166
    • Gao, P.1    Ding, Q.2    Wu, Z.3    Jiang, H.4    Fang, Z.5
  • 41
    • 85102978574 scopus 로고    scopus 로고
    • Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment (vol. 12, pg 615, 2010)
    • Kidd S., Caldwell L., Dietrich M., Samudio I., Spaeth E.L., Watson K., et al. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment (vol. 12, pg 615, 2010). Cytotherapy 2011, 13. 498.
    • (2011) Cytotherapy , vol.13 , pp. 498
    • Kidd, S.1    Caldwell, L.2    Dietrich, M.3    Samudio, I.4    Spaeth, E.L.5    Watson, K.6
  • 42
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    • Studeny M., Marini F.C., Champlin R.E., Zompetta C., Fidler I.J., AndreeffM. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002, 62:3603-3608.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3    Zompetta, C.4    Fidler, I.J.5    Andreeff, M.6
  • 43
    • 54549092165 scopus 로고    scopus 로고
    • Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model
    • Ren C., Kumar S., Chanda D., Kallman L., Chen J., Mountz J.D., et al. Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model. Gene Ther 2008, 15:1446-1453.
    • (2008) Gene Ther , vol.15 , pp. 1446-1453
    • Ren, C.1    Kumar, S.2    Chanda, D.3    Kallman, L.4    Chen, J.5    Mountz, J.D.6
  • 44
    • 34547543191 scopus 로고    scopus 로고
    • Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors
    • Hakkarainen T., Sarkioja M., Lehenkari P., Miettinen S., Ylikomi T., Suuronen R., et al. Human mesenchymal stem cells lack tumor tropism but enhance the antitumor activity of oncolytic adenoviruses in orthotopic lung and breast tumors. Hum Gene Ther 2007, 18:627-641.
    • (2007) Hum Gene Ther , vol.18 , pp. 627-641
    • Hakkarainen, T.1    Sarkioja, M.2    Lehenkari, P.3    Miettinen, S.4    Ylikomi, T.5    Suuronen, R.6
  • 45
    • 67651011690 scopus 로고    scopus 로고
    • Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy
    • Uchibori R., Okada T., Ito T., Urabe M., Mizukami H., Kume A., et al. Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J Gene Med 2009, 11:373-381.
    • (2009) J Gene Med , vol.11 , pp. 373-381
    • Uchibori, R.1    Okada, T.2    Ito, T.3    Urabe, M.4    Mizukami, H.5    Kume, A.6
  • 46
    • 58149200539 scopus 로고    scopus 로고
    • Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice
    • Kucerova L., Matuskova M., Pastorakova A., Tyciakova S., Jakubikova J., Bohovic R., et al. Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice. J Gene Med 2008, 10:1071-1082.
    • (2008) J Gene Med , vol.10 , pp. 1071-1082
    • Kucerova, L.1    Matuskova, M.2    Pastorakova, A.3    Tyciakova, S.4    Jakubikova, J.5    Bohovic, R.6
  • 47
    • 84870929405 scopus 로고    scopus 로고
    • Preactivation of human MSCs with TNF-alpha enhances tumor-suppressive activity
    • Lee R.H., Yoon N., Reneau J.C., Prockop D.J. Preactivation of human MSCs with TNF-alpha enhances tumor-suppressive activity. Cell Stem Cell 2012, 11:825-835.
    • (2012) Cell Stem Cell , vol.11 , pp. 825-835
    • Lee, R.H.1    Yoon, N.2    Reneau, J.C.3    Prockop, D.J.4
  • 48
    • 0037315457 scopus 로고    scopus 로고
    • Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex
    • Holler N., Tardivel A., Kovacsovics-Bankowski M., Hertig S., Gaide O., Martinon F., et al. Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol 2003, 23:1428-1440.
    • (2003) Mol Cell Biol , vol.23 , pp. 1428-1440
    • Holler, N.1    Tardivel, A.2    Kovacsovics-Bankowski, M.3    Hertig, S.4    Gaide, O.5    Martinon, F.6
  • 49
    • 84888367722 scopus 로고    scopus 로고
    • Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus
    • Stenqvist A.C., Nagaeva O., Baranov V., Mincheva-Nilsson L. Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus. J Immunol 2013, 191:5515-5523.
    • (2013) J Immunol , vol.191 , pp. 5515-5523
    • Stenqvist, A.C.1    Nagaeva, O.2    Baranov, V.3    Mincheva-Nilsson, L.4
  • 50
    • 3843107921 scopus 로고    scopus 로고
    • The secretable form of trimeric TRAIL, a potent inducer of apoptosis
    • Kim M.H., Billiar T.R., Seol D.W. The secretable form of trimeric TRAIL, a potent inducer of apoptosis. Biochem Biophys Res Commun 2004, 321:930-935.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 930-935
    • Kim, M.H.1    Billiar, T.R.2    Seol, D.W.3
  • 51
    • 84905734365 scopus 로고    scopus 로고
    • Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity
    • Graves J.D., Kordich J.J., Huang T.H., Piasecki J., Bush T.L., Sullivan T., et al. Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity. Cancer Cell 2014, 26:177-189.
    • (2014) Cancer Cell , vol.26 , pp. 177-189
    • Graves, J.D.1    Kordich, J.J.2    Huang, T.H.3    Piasecki, J.4    Bush, T.L.5    Sullivan, T.6
  • 53
    • 2542611366 scopus 로고    scopus 로고
    • Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis
    • Nesterov A., Nikrad M., Johnson T., Kraft A.S. Oncogenic Ras sensitizes normal human cells to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2004, 64:3922-3927.
    • (2004) Cancer Res , vol.64 , pp. 3922-3927
    • Nesterov, A.1    Nikrad, M.2    Johnson, T.3    Kraft, A.S.4
  • 54
    • 33847218950 scopus 로고    scopus 로고
    • C-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis
    • Nieminen A.I., Partanen J.I., Hau A., Klefstrom J. c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis. EMBO J 2007, 26:1055-1067.
    • (2007) EMBO J , vol.26 , pp. 1055-1067
    • Nieminen, A.I.1    Partanen, J.I.2    Hau, A.3    Klefstrom, J.4
  • 55
    • 84887212386 scopus 로고    scopus 로고
    • Possible novel therapy for malignant gliomas with secretable trimeric TRAIL
    • Jeong M., Kwon Y.S., Park S.H., Kim C.Y., Jeun S.S., Song K.W., et al. Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS One 2009, 4:e4545.
    • (2009) PLoS One , vol.4 , pp. e4545
    • Jeong, M.1    Kwon, Y.S.2    Park, S.H.3    Kim, C.Y.4    Jeun, S.S.5    Song, K.W.6
  • 56
    • 3242725832 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1)
    • Chopin V., Slomianny C., Hondermarck H., Le Bourhis X. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Exp Cell Res 2004, 298:560-573.
    • (2004) Exp Cell Res , vol.298 , pp. 560-573
    • Chopin, V.1    Slomianny, C.2    Hondermarck, H.3    Le Bourhis, X.4
  • 58
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo M., Kim T.H., Seol D.W., Esplen J.E., Dorko K., Billiar T.R., et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 2000, 6:564-567.
    • (2000) Nat Med , vol.6 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6
  • 59
    • 77956414973 scopus 로고    scopus 로고
    • Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
    • Herbst R.S., Eckhardt S.G., Kurzrock R., Ebbinghaus S., O'Dwyer P.J., Gordon M.S., et al. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol 2010, 28:2839-2846.
    • (2010) J Clin Oncol , vol.28 , pp. 2839-2846
    • Herbst, R.S.1    Eckhardt, S.G.2    Kurzrock, R.3    Ebbinghaus, S.4    O'Dwyer, P.J.5    Gordon, M.S.6
  • 60
    • 84856024143 scopus 로고    scopus 로고
    • Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours
    • Pan Y., Xu R., Peach M., Huang C.P., Branstetter D., Novotny W., et al. Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours. Br J Cancer 2011, 105:1830-1838.
    • (2011) Br J Cancer , vol.105 , pp. 1830-1838
    • Pan, Y.1    Xu, R.2    Peach, M.3    Huang, C.P.4    Branstetter, D.5    Novotny, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.