Polymorphisms of the TGFBRAP1 gene in relation to blood pressure variability and plasma TGF-β1

Clinical and Experimental Hypertension

Volumn 37, Issue 5, 2015, Pages 420-425

  Guo, Daoxia ^a   Shen, Chong ^b   Chen, Yanchun ^c   Yang, Song ^c   Wang, Linhong ^a   Jin, Yuelong ^a   He, Lianping ^a   Chen, Jinfeng ^b   Zhao, Xianghai ^c   Zhou, Wei ^c   Zhao, Hailong ^b   Yao, Yingshui ^a  

^a WANNAN MEDICAL COLLEGE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c YIXING PEOPLE S HOSPITAL   (China)

Author keywords

Association study; Blood pressure variability; Essential hypertension; Plasma tgf b1 levels; Tgfbrap1

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSFORMING GROWTH FACTOR BETA1; DNA; SIGNAL PEPTIDE; TGFBRAP1 PROTEIN, HUMAN;

ADULT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD PRESSURE VARIABILITY; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HEREDITY; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; TGFBRAP1 GENE; BLOOD; BLOOD PRESSURE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY;

BLOOD PRESSURE; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RETROSPECTIVE STUDIES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84944057036     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.3109/10641963.2015.1013113     Document Type: Article

References (20)

1. Giles TD, Berk BC, Black HR, et al. Expanding the definition and classification of hypertension. J Clin Hypertens (Greenwich) 2005; 7:505-12.
2. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: Roles of apoptosis, inflammation, and fibrosis. Hypertension 2001; 38:581-7.
3. Bobik A. Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol 2006;26:1712-20.
4. Verrecchia F, Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation. J Invest Dermatol 2002;118:211-15.
5. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390: 465-71.
6. Zacchigna L, Vecchione C, Notte A, et al. Emilin1 links TGF-beta maturation to blood pressure homeostasis. Cell 2006;124:929-42.
7. Hartner A, Schaefer L, Porst M, et al. Role of fibrillin-1 in hypertensive and diabetic glomerular disease. Am J Physiol Renal Physiol 2006;290:F1329-36.
8. Shen C, Lu X, Li Y, et al. Emilin1 gene and essential hypertension: A two-stage association study in northern Han Chinese population. BMC Med Genet 2009;10:118.
9. Shen C, Lu X, Wang L, et al. Novel genetic variation in exon 28 of FBN1 gene is associated with essential hypertension. Am J Hypertens 2011;24:687-93.
10. Shimodaira M, Nakayama T, Sato N, et al. Association study of the elastin microfibril interfacer 1 (EMILIN1) gene in essential hypertension. Am J Hypertens 2010;23:547-55.
11. Mi DQ, Wang BY, Sun H, et al. Association of EMILIN1 gene polymorphism with essential hypertension in Mongolian. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2011;28:160-4.
12. Huang T, David L, Mendoza V, et al. TGF-beta signalling is mediated by two autonomously functioning TbetaRI:TbetaRII pairs. EMBO J 2011;30:1263-76.
13. Chen J, Zhao X, Wang H, et al. Common Variants in TGFBR2 and miR-518 Genes Are Associated With Hypertension in the Chinese Population. Am J Hypertens 2014;27:1268-76.
14. Charng MJ, Zhang D, Kinnunen P, et al. A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. J Biol Chem 1998;273: 9365-8.
15. Wurthner JU, Frank DB, Felici A, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem 2001;276:19495-502.
16. Li YP, Hu XQ, Jing Z, et al. Application of the WHO growth reference (2007) to assess the nutritional status of children in China. Biomed Environ Sci 2009;22:130-5.
17. Guo SW, Thompson EA. Performing the exact test of Hardy- Weinberg proportion for multiple alleles. Biometrics 1992;48: 361-72.
18. Schmidt M, Paes K, De Maziere A, et al. EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development 2007;134: 2913-23.
19. Agrotis A, Kalinina N, Bobik A. Transforming growth factor-beta, cell signaling and cardiovascular disorders. Curr Vasc Pharmacol 2005;3:55-61.
20. Chen J, Yang S, Zhao X, et al. Association study of common variations of FBN1 gene and essential hypertension in Han Chinese population. Mol Biol Rep 2014;41:2257-64.