Comparative evaluation of the efficacy of curcumin gel with and without photo activation as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A split mouth clinical and microbiological study

Journal of Natural Science, Biology and Medicine

Volumn 6, Issue , 2015, Pages S102-S109

  Sreedhar, Annaji ^a   Sarkar, Indranil ^a   Rajan, Padma ^a   Pai, Jagdish ^a   Malagi, Sachin ^a   Kamath, Vinesh ^a   Barmappa, Radhikka ^a  

^a Rajiv Gandhi University of Health Sciences   (India)

Author keywords

Aggregatibacter actinomycetemcomitans; black pigment producing microorganisms; chronic periodontitis; curcumin; photodynamic therapy; reactive oxygen species; turmeric

Indexed keywords

EID: 84944056523     PISSN: 09769668     EISSN: 22297707     Source Type: Journal    
DOI: 10.4103/0976-9668.166100     Document Type: Article

References (61)

1. Ammon HP, Anazodo MI, Safayhi H, Dhawan BN, Srimal RC. Curcumin: A potent inhibitor of leukotriene B4 formation in rat peritoneal polymorphonuclear neutrophils (PMNL). Planta Med 1992;58:226.
2. Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Curr Sci 2004;87:44-54.
3. Milobedzka J, Kostanecki S, Lampe V. Knowledge of curcumin. Ber Dtsch Chem Ges 1910;43:2163-70.
4. Lampe V, Milobedzka J. Studies on curcumin. Ber Dtsch Chem Ges 1913;46:2235-7.
5. Srinivasan KR. A chromatographic study of the curcuminoids in Curcuma longa, L. J Pharm Pharmacol 1953;5:448-57.
6. Kim GY, Kim KH, Lee SH, Yoon MS, Lee HJ, Moon DO, et al. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol 2005;174:8116-24.
7. Gulcubuk A, Altunatmaz K, Sonmez K, Haktanir-Yatkin D, Uzun H, Gurel A, et al. Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet Med A Physiol Pathol Clin Med 2006;53:49-54.
8. Moon DO, Kim MO, Choi YH, Park YM, Kim GY. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int Immunopharmacol 2010;10:605-10.
9. Mun SH, Kim HS, Kim JW, Ko NY, Kim do K, Lee BY, et al. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collageninduced arthritis: Inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci 2009;111:13-21.
10. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern Med Rev 2009;14:141-53.
11. Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res 2009;58:899-908.
12. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005;280:9409-15.
13. Epstein J, Docena G, MacDonald TT, Sanderson IR. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr 2010;103:824-32.
14. Hanai H, Sugimoto K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr Pharm Des 2009;15:2087-94.
15. Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: A pilot study. Dig Dis Sci 2005;50:2191-3.
16. Jagetia GC, Rajanikant GK. Curcumin treatment enhances the repair and regeneration of wounds in mice exposed to hemibody gammairradiation. Plast Reconstr Surg 2005;115:515-28.
17. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci 2006;78:2081-7.
18. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998;6:167-77.
19. Huang Z. A review of progress in clinical photodynamic therapy. Technol Cancer Res Treat 2005;4:283-93.
20. Al-Watban FA, Zhang XY. Photodynamic therapy of human undifferentiated thyroid carcinoma-bearing nude mice using topical 5-aminolevulinic acid. Photomed Laser Surg 2005;23:206-11.
21. Kömerik N, Wilson M. Factors influencing the susceptibility of Gram-negative bacteria to toluidine blue O-mediated lethal photosensitization. J Appl Microbiol 2002;92:618-23.
22. Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: A short review. Life Sci 2006;78:2081-7.
23. Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen 1998;6:167-77.
24. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: The Indian solid gold. Adv Exp Med Biol 2007;595:1-75.
25. Haukvik T, Bruzell E, Kristensen S, Tønnesen HH. Photokilling of bacteria by curcumin in selected polyethylene glycol 400 (PEG 400) preparations. Studies on curcumin and curcuminoids, XLI. Pharmazie 2010;65:600-6.
26. Fontana CR, Abernethy AD, Som S, Ruggiero K, Doucette S, Marcantonio RC, et al. The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. J Periodontal Res 2009;44:751-9.
27. Metcalf D, Robinson C, Devine D, Wood S. Enhancement of erythrosine-mediated photodynamic therapy of Streptococcus mutans biofilms by light fractionation. J Antimicrob Chemother 2006;58:190-2.
28. Wood S, Metcalf D, Devine D, Robinson C. Erythrosine is a potential photosensitizer for the photodynamic therapy of oral plaque biofilms. J Antimicrob Chemother 2006;57:680-4.
29. Zanin IC, Lobo MM, Rodrigues LK, Pimenta LA, Höfling JF, Gonçalves RB. Photosensitization of in vitro biofilms by toluidine blue O combined with a light-emitting diode. Eur J Oral Sci 2006;114:64-9.
30. Komerik N, MacRobert AJ. Photodynamic therapy as an alternative antimicrobial modality for oral infections. J Environ Pathol Toxicol Oncol 2006;25:487-504.
31. Zanin IC, Gonçalves RB, Junior AB, Hope CK, Pratten J. Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: An in vitro study. J Antimicrob Chemother 2005;56:324-30.
32. Silness J, Loe h. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:121-35.
33. Mhlemann HR, Son S. Gingival sulcus bleeding - A leading symptom in initial gingivitis. Helv Odontol Acta 1971;15:107-13.
34. Slots J. Selective medium for isolation of Actinobacillus actinomycetemcomitans. J Clin Microbiol 1982;15:606-9.
35. Zambon JJ, Reynolds HS, Slots J. Black-pigmented Bacteroides spp. in the human oral cavity. Infect Immun 1981;32:198-203.
36. Carvalho LH, D'Avila GB, Leão A, Haffajee AD, Socransky SS, Feres M. Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. clinical results. J Clin Periodontol 2004;31:1070-6.
37. Bollen CM, Quirynen M. Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. J Periodontol 1996;67:1143-58.
38. Greenstein G. Nonsurgical periodontal therapy in 2000: A literature review. J Am Dent Assoc 2000;131:1580-92.
39. Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: Diagnosis and treatment. Clin Microbiol Rev 2001;14:727-52.
40. Sigusch B, Beier M, Klinger G, Pfister W, Glockmann E. A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. J Periodontol 2001;72:275-83.
41. Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res 2002;37:389-98.
42. Slots J, Rams TE. Antibiotics in periodontal therapy: Advantages and disadvantages. J Clin Periodontol 1990;17(Pt 2):479-93.
43. Shiloah J, Patters MR. DNA probe analyses of the survival of selected periodontal pathogens following scaling, root planing, and intra-pocket irrigation. J Periodontol 1994;65:568-75.
44. Renvert S, Wikström M, Dahlén G, Slots J, Egelberg J. On the inability of root debridement and periodontal surgery to eliminate Actinobacillus actinomycetemcomitans from periodontal pockets. J Clin Periodontol 1990;17:351-5.
45. Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46:269-79.
46. O'Neill JF, Hope CK, Wilson M. Oral bacteria in multi-species biofilms can be killed by red light in the presence of toluidine blue. Lasers Surg Med 2002;31:86-90.
47. Williams JA, Pearson GJ, Colles MJ, Wilson M. The effect of variable energy input from a novel light source on the photoactivated bactericidal action of toluidine blue O on Streptococcus Mutans. Caries Res 2003;37:190-3.
48. Wilson M, Dobson J, Harvey W. Sensitization of oral bacteria to killing by low-power laser radiation. Curr Microbiol 1992;25:77-81.
49. Wilson M, Burns T, Pratten J. Killing of Streptococcus sanguis in biofilms using a light-activated antimicrobial agent. J Antimicrob Chemother 1996;37:377-81.
50. Wilson M, Burns T, Pratten J, Pearson GJ. Bacteria in supragingival plaque samples can be killed by low-power laser light in the presence of a photosensitizer. J Appl Bacteriol 1995;78:569-74.
51. Giusti JS, Santos-Pinto L, Pizzolito AC, Helmerson K, Carvalho-Filho E, Kurachi C, et al. Antimicrobial photodynamic action on dentin using a light-emitting diode light source. Photomed Laser Surg 2008;26:281-7.
52. Al-Watban FA, Zhang XY. Photodynamic therapy of human undifferentiated thyroid carcinoma-bearing nude mice using topical 5-aminolevulinic acid. Photomed Laser Surg 2005;23:206-11.
53. Kömerik N, Wilson M. Factors influencing the susceptibility of Gram-negative bacteria to toluidine blue O-mediated lethal photosensitization. J Appl Microbiol 2002;92:618-23.
54. Muglikar S, Patil KC, Shivswami S, Hegde R. Efficacy of curcumin in the treatment of chronic gingivitis: A pilot study. Oral Health Prev Dent 2013;11:81-6.
55. Gottumukkala SN, Koneru S, Mannem S, Mandalapu N. Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial. Contemp Clin Dent 2013;4:186-91.
56. Guimarães MR, Coimbra LS, de Aquino SG, Spolidorio LC, Kirkwood KL, Rossa C Jr. Potent anti-inflammatory effects of systemically administered curcumin modulate periodontal disease in vivo. J Periodontal Res 2011;46:269-79.
57. Chen H, Zhang ZS, Zhang YL, Zhou DY. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 1999;19: 3675-80.
58. Bhavani Shankar TN, Sreenivasa Murthy V. Effect of turmeric (Curcuma longa) fractions on the growth of some intestinal & pathogenic bacteria in vitro. Indian J Exp Biol 1979;17:1363-6.
59. Araújo NC, Fontana CR, Bagnato VS, Gerbi ME. Photodynamic effects of curcumin against cariogenic pathogens. Photomed Laser Surg 2012;30:393-9.
60. Araújo NC, Fontana CR, Gerbi ME, Bagnato VS. Overall-mouth disinfection by photodynamic therapy using curcumin. Photomed Laser Surg 2012;30:96-101.
61. Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol 2011;15:35-8.