Pathophysiology of hidradenitis suppurativa: An update

Journal of the American Academy of Dermatology

Volumn 73, Issue 5, 2015, Pages S8-S11

  Prens, Errol ^a   Deckers, Inge ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

acne inversa; antimicrobial peptides; autoinflammation; cytokines; friction; hidradenitis suppurativa; immunology; tobacco smoke

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; NICASTRIN; POLYPEPTIDE ANTIBIOTIC AGENT; PRESENILIN 1; PRESENILIN 2; SEX HORMONE;

ARTICLE; CYTOKINE RESPONSE; ENVIRONMENTAL FACTOR; FOLLICULAR OCCLUSION; HAIR FOLLICLE; HEREDITY; HUMAN; IMMUNOGENETICS; INFLAMMATION; LOSS OF FUNCTION MUTATION; MICROBIAL COLONIZATION; OBESITY; OCCLUSION; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SMOKING; SUPPURATIVE HIDRADENITIS; T LYMPHOCYTE; ADULT; ADVERSE EFFECTS; APOCRINE GLAND; AUTOIMMUNITY; DISEASE COURSE; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; NEEDLE BIOPSY; PHYSIOLOGY; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; APOCRINE GLANDS; AUTOIMMUNITY; BIOPSY, NEEDLE; CYTOKINES; DISEASE PROGRESSION; FEMALE; HIDRADENITIS SUPPURATIVA; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SMOKING; YOUNG ADULT;

EID: 84944032021     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2015.07.045     Document Type: Article

References (41)

1. C.C. Yu, and M.G. Cook Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands Br J Dermatol 122 1990 763 769
2. J. Boer, and E.F. Weltevreden Hidradenitis suppurativa or acne inversa. A clinicopathological study of early lesions Br J Dermatol 135 1996 721 725
3. G.B. Jemec, and U. Hansen Histology of hidradenitis suppurativa J Am Acad Dermatol 34 1996 994 999
4. M. von Laffert, P. Helmbold, J. Wohlrab, E. Fiedler, V. Stadie, and W.C. Marsch Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis Exp Dermatol 19 2010 533 537
5. M. von Laffert, V. Stadie, J. Wohlrab, and W.C. Marsch Hidradenitis suppurativa/acne inversa: bilocated epithelial hyperplasia with very different sequelae Br J Dermatol 164 2011 367 371
6. A. Grant, T. Gonzalez, M.O. Montgomery, V. Cardenas, and F.A. Kerdel Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial J Am Acad Dermatol 62 2010 205 217
7. I. Miller, C.D. Lynggaard, S. Lophaven, C. Zachariae, D.N. Dufour, and G.B. Jemec A double-blind placebo-controlled randomized trial of adalimumab in the treatment of hidradenitis suppurativa Br J Dermatol 165 2011 391 398
8. G. Kelly, C.M. Sweeney, A.M. Tobin, and B. Kirby Hidradenitis suppurativa: the role of immune dysregulation Int J Dermatol 53 2014 1186 1196
9. B. Wang, W. Yang, W. Wen, and et al. Gamma-secretase gene mutations in familial acne inversa Science 330 2010 1065
10. F. Radtke, N. Fasnacht, and H.R. Macdonald Notch signaling in the immune system Immunity 32 2010 14 27
11. M.E. Gentle, A. Rose, L. Bugeon, and M.J. Dallman Noncanonical Notch signaling modulates cytokine responses of dendritic cells to inflammatory stimuli J Immunol 189 2012 1274 1284
12. C.J. Smith, and C. Hansch The relative toxicity of compounds in mainstream cigarette smoke condensate Food Chem Toxicol 38 2000 637 646
13. C. Esser, A. Rannug, and B. Stockinger The aryl hydrocarbon receptor in immunity Trends Immunol 30 2009 447 454
14. A. Hana, D. Booken, C. Henrich, and et al. Functional significance of non-neuronal acetylcholine in skin epithelia Life Sci 80 2007 2214 2220
15. J.K. Nikota, P. Shen, M.C. Morissette, and et al. Cigarette smoke primes the pulmonary environment to IL-1alpha/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice J Immunol 193 2014 3134 3145
16. H.H. van der Zee, J.D. Laman, J. Boer, and E.P. Prens Hidradenitis suppurativa: viewpoint on clinical phenotyping, pathogenesis and novel treatments Exp Dermatol 21 2012 735 739
17. C.S. Pavia, A. Pierre, and J. Nowakowski Antimicrobial activity of nicotine against a spectrum of bacterial and fungal pathogens J Med Microbiol 49 2000 675 676
18. J.A. Hutcherson, D.A. Scott, and J. Bagaitkar Scratching the surface - tobacco-induced bacterial biofilms Tob Induc Dis 13 2015 1
19. K. Wolk, K. Warszawska, C. Hoeflich, and et al. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa J Immunol 186 2011 1228 1239
20. C. Schlapbach, N. Yawalkar, and R.E. Hunger Human beta-defensin-2 and psoriasin are overexpressed in lesions of acne inversa J Am Acad Dermatol 61 2009 58 65
21. B.C. Melnik, and G. Plewig Impaired Notch signalling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa) Br J Dermatol 168 2013 876 878
22. I.E. Deckers, H.H. van der Zee, and E.P. Prens Epidemiology of hidradenitis suppurativa: prevalence, pathogenesis, and factors associated with the development of HS Curr Dermatol Rep 3 2014 54 60
23. J.H. Barth, and T. Kealey Androgen metabolism by isolated human axillary apocrine glands in hidradenitis suppurativa Br J Dermatol 125 1991 304 308
24. M.G. Buimer, T. Wobbes, J.H. Klinkenbijl, M.M. Reijnen, and W.A. Blokx Immunohistochemical analysis of steroid hormone receptors in hidradenitis suppurativa Am J Dermatopathol 37 2015 129 132
25. J. Revuz Hidradenitis suppurativa J Eur Acad Dermatol Venereol 23 2009 985 998
26. A. Alikhan, P.J. Lynch, and D.B. Eisen Hidradenitis suppurativa: a comprehensive review J Am Acad Dermatol 60 2009 539 561
27. A. Lee, and G. Fischer A case series of 20 women with hidradenitis suppurativa treated with spironolactone Australas J Dermatol 56 2015 192 196
28. K. de Winter, H.H. van der Zee, and E.P. Prens Is mechanical stress an important pathogenic factor in hidradenitis suppurativa? Exp Dermatol 21 2012 176 177
29. M.R. Schneider, and R. Paus Deciphering the functions of the hair follicle infundibulum in skin physiology and disease Cell Tissue Res 358 2014 697 704
30. V.W. Wong, S. Akaishi, M.T. Longaker, and G.C. Gurtner Pushing back: wound mechanotransduction in repair and regeneration J Invest Dermatol 131 2011 2186 2196
31. E. Mozeika, M. Pilmane, B.M. Nurnberg, and G.B. Jemec Tumour necrosis factor-alpha and matrix metalloproteinase-2 are expressed strongly in hidradenitis suppurativa Acta Derm Venereol 93 2013 301 304
32. B. Dreno, A. Khammari, A. Brocard, and et al. Hidradenitis suppurativa: the role of deficient cutaneous innate immunity Arch Dermatol 148 2012 182 186
33. V.U. Emelianov, F.G. Bechara, R. Glaser, and et al. Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa Br J Dermatol 166 2012 1023 1034
34. J.J. O'Shea, A. Ma, and P. Lipsky Cytokines and autoimmunity Nat Rev Immunol 2 2002 37 45
35. H.H. van der Zee, L. de Ruiter, D.G. van den Broecke, W.A. Dik, J.D. Laman, and E.P. Prens Elevated levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-alpha and IL-1beta Br J Dermatol 164 2011 1292 1298
36. E.J. Giamarellos-Bourboulis, A. Antonopoulou, C. Petropoulou, and et al. Altered innate and adaptive immune responses in patients with hidradenitis suppurativa Br J Dermatol 156 2007 51 56
37. L. Matusiak, A. Bieniek, and J.C. Szepietowski Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents? Acta Derm Venereol 89 2009 601 603
38. H.H. van der Zee, J.D. Laman, L. de Ruiter, W.A. Dik, and E.P. Prens Adalimumab (antitumour necrosis factor-alpha) treatment of hidradenitis suppurativa ameliorates skin inflammation: an in situ and ex vivo study Br J Dermatol 166 2012 298 305
39. C. Schlapbach, T. Hanni, N. Yawalkar, and R.E. Hunger Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa J Am Acad Dermatol 65 2011 790 798
40. M.S. Maddur, P. Miossec, S.V. Kaveri, and J. Bayry Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies Am J Pathol 181 2012 8 18
41. R.R. Keijsers, I. Joosten, P.E. van Erp, H.J. Koenen, and P.C. van de Kerkhof Cellular sources of IL-17 in psoriasis: a paradigm shift? Exp Dermatol 23 2014 799 803