ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo

Cytokine

Volumn 76, Issue 2, 2015, Pages 569-571

  Ketscher, Lars ^a   Knobeloch, Klaus Peter ^b  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Interferon; ISG15; Stat1; USP18; Virus

Indexed keywords

INTERFERON STIMULATED GENE 15 PROTEIN; PROTEINASE; TRANSCRIPTION FACTOR; UBIQUITIN SPECIFIC PROTEASE 18; UNCLASSIFIED DRUG; CYTOKINE; G1P2 PROTEIN, MOUSE; UBIQUITIN; UBIQUITIN THIOLESTERASE; USP18 PROTEIN, MOUSE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COXSACKIEVIRUS B3; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; INFECTION RESISTANCE; INFLUENZA B; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; VACCINIA; ANIMAL; METABOLISM; PROTEIN PROCESSING;

ANIMALS; CYTOKINES; MICE; PROTEIN PROCESSING, POST-TRANSLATIONAL; UBIQUITIN THIOLESTERASE; UBIQUITINS;

EID: 84943820341     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2015.03.006     Document Type: Article

References (14)

1. Jeon Y.J., Yoo H.M., Chung C.H. ISG15 and immune diseases. Biochim Biophys Acta 2010, 1802:485-496. 10.1016/j.bbadis.2010.02.006.
2. Morales D.J., Lenschow D.J. The antiviral activities of ISG15. J Mol Biol 2013, 425:4995-5008. 10.1016/j.jmb.2013.09.041.
3. Zhao C., Collins M.N., Hsiang T.-Y., Krug R.M. Interferon-induced ISG15 pathway: an ongoing virus-host battle. Trends Microbiol 2013, 21:181-186. 10.1016/j.tim.2013.01.005.
4. Park J.M., Yang S.W., Yu K.R., Ka S.H., Lee S.W., Seol J.H., et al. Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis. Mol Cell 2014, 54:626-638. 10.1016/j.molcel.2014.03.031.
5. Bogunovic D., Byun M., Durfee L.A., Abhyankar A., Sanal O., Mansouri D., et al. Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science 2012, 337:1684-1688. 10.1126/science.1224026.
6. Werneke S.W., Schilte C., Rohatgi A., Monte K.J., Michault A., Arenzana-Seisdedos F., et al. ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation. PLoS Pathog 2011, 7:e1002322. 10.1371/journal.ppat.1002322.
7. Catic A., Fiebiger E., Korbel G.A., Blom D., Galardy P.J., Ploegh H.L. Screen for ISG15-crossreactive deubiquitinases. PloS One 2007, 2:e679. 10.1371/journal.pone.0000679.
8. Malakhova O.A., Kim K.I., Luo J.-K., Zou W., Kumar K.G.S., Fuchs S.Y., et al. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J 2006, 25:2358-2367. 10.1038/sj.emboj.7601149.
9. Osiak A., Utermöhlen O., Niendorf S., Horak I., Knobeloch K.-P. ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol 2005, 25:6338-6345. 10.1128/MCB.25.15.6338-6345.2005.
10. Kim K.I., Yan M., Malakhova O., Luo J.-K., Shen M.-F., Zou W., et al. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol Cell Biol 2006, 26:472-479. 10.1128/MCB.26.2.472-479.2006.
11. Arimoto K.-I., Hishiki T., Kiyonari H., Abe T., Cheng C., Yan M., et al. Murine Herc6 Plays a critical role in protein ISGylation in vivo and has an ISGylation-independent function in seminal vesicles. J Interferon Cytokine Res Off J Int Soc Interferon Cytokine Res 2014, 10.1089/jir.2014.0113.
12. Ritchie K.J., Malakhov M.P., Hetherington C.J., Zhou L., Little M.-T., Malakhova O.A., et al. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes Dev 2002, 16:2207-2212. 10.1101/gad.1010202.
13. Ketscher L., Hannß R., Morales D.J., Basters A., Guerra S., Goldmann T., et al. Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci USA 2015, 112:1577-1582. 10.1073/pnas.1412881112.
14. Rahnefeld A., Klingel K., Schuermann A., Diny N.L., Althof N., Lindner A., et al. Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy. Circulation 2014, 130:1589-1600. 10.1161/CIRCULATIONAHA.114.009847.