Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3

Cancer Biology and Therapy

Volumn 16, Issue 4, 2015, Pages 541-548

  Jing, Zhang ^a   Heng, Wei ^a   Xia, Liu ^a   Ning, Wang ^a   Yafei, Qi ^a   Yao, Zhang ^a   Shulan, Zhang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Bcl 2; Caspase 3; Cervical adenocarcinoma; Chemotherapy sensitivity; Metabolism; PHGDH; proliferation

Indexed keywords

CASPASE 3; CISPLATIN; PHOSPHOGLYCERATE DEHYDROGENASE; PROTEIN BCL 2; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ADENOCARCINOMA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CARCINOGENESIS; CELL PROLIFERATION; CERVICAL ADENOCARCINOMA; CHEMOSENSITIVITY; CLINICAL FEATURE; CONTROLLED STUDY; CYTOTOXICITY TEST; DISEASE ASSOCIATION; DOWN REGULATION; DRUG EFFICACY; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HELA CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MIDDLE AGED; MOUSE; NONHUMAN; TUMOR VOLUME; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; GENETICS; NUDE MOUSE; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DOWN-REGULATION; FEMALE; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOSPHOGLYCERATE DEHYDROGENASE; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; UTERINE CERVICAL NEOPLASMS;

EID: 84943792679     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.1080/15384047.2015.1017690     Document Type: Article

References (26)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90; PMID: 21296855; http://dx. doi. org/10. 3322/caac. 20107.
2. Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJ, Naghavi M. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet 2011; 378: 1461-84; PMID: 21924486; http://dx. doi. org/10. 1016/S0140-6736(11)61351-2.
3. Mathew A, George PS. Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix-worldwide. Asian Pac J Cancer Prev 2009; 10: 645-50; PMID: 19827887.
4. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011; 43: 869-74; PMID: 21804546; http://dx. doi. org/10. 1038/ng. 890.
5. Snell K, Natsumeda Y, Eble JN, Glover JL, Weber G. Enzymic imbalance in serine metabolism in human colon carcinoma andrat sarcoma. Br J Cancer 1988; 57: 87-90; PMID: 3126791.
6. Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell Melanoma Res 2011; 24: 1112-5; PMID: 21981974; http://dx. doi. org/10. 1111/j. 1755-148X.
7. Liu J, Guo S, Li Q, Yang L, Xia Z, Zhang L, Huang Z, Zhang N. Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1. J Neurooncol 2013; 111: 245-55; PMID: 23229761; http://dx. doi. org/10. 1007/s11060-012-1018-x.
8. Cho HM, Jun DY, Bae MA, Ahn JD, Kim YH. Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene. Gene 2000; 245: 193-201; PMID: 10713460.
9. Jing Z, Heng W, Aiping D, Yafei Q, Shulan Z. Expression and clinicalsignificance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer. Int J Gynecol Cancer 2013; 23: 1465-9; PMID: 24247658; http://dx. doi. org/10. 1097/IGC. 0b013e3182a0c068.
10. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74; PMID: 21376230; http://dx. doi. org/10. 1016/j. cell. 2011. 02. 013.
11. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11: 85-95; PMID: 21258394; http://dx. doi. org/10. 1038/nrc2981.
12. DeBerardinis RJ. Serine metabolism: some tumors take the road less traveled. Cell Metab 2011; 14: 285-6; PMID: 21907134; http://dx. doi. org/10. 1016/j. cmet. 2011. 08. 004.
13. Ward PS, Thompson CB. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate. Cancer Cell 2012; 21: 297-308; PMID: 22439925; http://dx. doi. org/10. 1016/j. ccr. 2012. 02. 014.
14. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011; 476: 346-50; PMID: 21760589; http://dx. doi. org/10. 1038/nature10350.
15. Snell K, Weber G. Enzymic imbalance in serine metabolism in rat hepatomas. Biochem J 1986; 233: 617-20; PMID: 3082329.
16. Kim SK, Jung WH, Koo JS. Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. PLoS One 2014; 9: e101004; PMID: 24979213; http://dx. doi. org/10. 1371/journal. pone.
17. Chen J, Chung F, Yang G, Pu M, Gao H, Jiang W, Yin H, Capka V, Kasibhatla S, Laffitte B, et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget 2013; 4: 2502-11; PMID: 24318446.
18. Shen D-W, Pouliot LM, Hall MD, Gottesman MM. Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes. Pharmacological Reviews 2012; 64: 706-21; PMID: 22659329; http://dx. doi. org/10. 1124/pr. 111. 005637.
19. Galluzzi L, Senovilla L, Vitale I, Michels J, Martins I, Kepp O, Castedo M, Kroemer G. Molecular mechanisms of cisplatin resistance. Oncogene 2012; 31: 1869-83; PMID: 21892204; http://dx. doi. org/10. 1038/onc. 2011. 384.
20. Kartalou M, Essigmann JM. Mechanisms of resistance to cisplatin. Mutat Res 2001; 478: 23-43; PMID: 11406167.
21. Wang C, Youle RJ. The role of mitochondria in apoptosis. Annu Rev Genet 2009; 43: 95-118; PMID: 19659442; http://dx. doi. org/10. 1146/annurevgenet-102108-134850.
22. Srivastava M, Ahmad N, Gupta S, Mukhtar H. Involvement of Bcl-2 and Bax in Photodynamic Therapy-mediated Apoptosis. J Biol Chem 2001; 276: 15481-88; PMID: 11278320.
23. Tsujimoto Y, Cossman J, Jaffe E, Croce CM. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985; 228: 1440-43; PMID: 3874430.
24. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bc1-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-19; PMID: 8358790.
25. Kim KY, Seol JY, Jeon GA, Nam MJ. The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cell. Cancer Lett 2003; 189: 157-66; PMID: 12490308.
26. Spina A, Sorvillo L, Di Maiolo F, Esposito A, D'Auria R, Di Gesto D, Chiosi E, Naviglio S. Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. J Cell Physiol 2013; 228: 198-206; PMID: 22674530; http://dx. doi. org/10. 1002/jcp. 2412.