G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex

Journal of Biochemistry

Volumn 157, Issue 6, 2015, Pages 561-569

  Ishimi, Yukio ^a   Irie, Daiki ^a  

^a IBARAKI UNIVERSITY   (Japan)

Author keywords

Cancer; DNA binding; DNA helicase; DNA replication; Gene mutation

Indexed keywords

DNA HELICASE; MINICHROMOSOME MAINTENANCE PROTEIN 4; MINICHROMOSOME MAINTENANCE PROTEIN 6; MINICHROMOSOME MAINTENANCE PROTEIN 7; MCM4 PROTEIN, HUMAN; MCM6 PROTEIN, HUMAN; MCM7 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CANCER CELL; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; CHEMISTRY; GENETICS; METABOLISM; PATHOLOGY; SITE DIRECTED MUTAGENESIS; SKIN TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; DNA HELICASES; HUMANS; MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 4; MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 6; MINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 7; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SKIN NEOPLASMS;

EID: 84943792505     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvv015     Document Type: Article

References (26)

1. Lengauer, CL, Kinzler, K.W., and Vogelstein, B. (1998) Genetic instabilities in human cancers. Nature 396, 643-649
2. Abbas, T., Keaton, M.A., and Dutta, A. (2013) Cold Spring Harb. Perspect. Biol. 5, a012914
3. Aguilera, A. and Garcia-Muse, T. (2013) Causes of genome instability. Annu. Rev. Genet. 47, 1-32
4. Bell, S.P. and Dutta, A. (2002) DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71, 333-374
5. Forsburg, S.L. (2004) Eukaryotic MCM proteins: beyond replication initiation. Microbiol. Mol. Biol. Rev. 68, 109-131
6. Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., and Oda, H. (2010) Eukaryotic chromosome DNA replication: where, when, and how? Annu. Rev. Biochem. 79, 89-130
7. Moyer, S.E., Lewis, P.W., and Botchan, M.R. (2006) Isolation of the Cdc45-MCM2-7-GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. USA 103, 10236-10241
8. Gambus, A., Jones, R.C., Sanchez-Diaz, A., Kanemaki, M., van Deursen, F., Edmondson, R.D., and Labib, K. (2006) GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8, 358-366
9. Labib, K. and Gambus, A. (2007) A keyrole for the GINS complex at DNA replication forks. Trends Cell Biol. 17, 271-278
10. Diffley, J.F. (2004) Regulation of early events in chromosome replication. Curr. Biol. 14, R778-R786
11. Shima, N, Alcaraz, A., Liachko, I., Buske, T.R., Andrews, CA., Munroe, R.J., Hartford, S.A., Tye, B.K., and Schimenti, J.C. (2007) A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat. Genet. 39, 93-98
12. Kawabata, T., Luebben, S.W., Yamaguchi, S., Ilves, I., Matise, I., Buske, T., Botchan, M.R., and Shima, N. (2011) Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol. Cell 41, 543-553
13. Watanabe, E., Ohara, R., and Ishimi, Y. (2012) Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation. J. Biochem. 152, 191-198
14. Chuang, C.-H., Yang, D., Bai, G, Freeland, A., Pruitt, S.C., and Schimenti, J.C. (2012) Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells. Nucleic Acids Res. 40, 4914-4924
15. Kusunoki, S. and Ishimi, Y. (2014) Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7. FEBS J. 281, 1057-1067
16. Ishimi, Y. (1997) A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J. Biol. Chem. 272, 24508-24513
17. Uno, S. and Masai, H. (2011) Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions. Genes Cells 16, 842-856
18. Takaya, J., Kusunoki, S., and Ishimi, Y. (2013) Protein interaction and cellular localization of human CDC45. J. Biochem. 153, 381-388
19. Lee, J.-K. and Hurwitz, J. (2000) Isolation and characterization of various complexes of the minichromosome maintenance protein of Schizosaccharomyces pombe. J. Biol. Chem. 275, 18871-18878
20. Kaplan, D.L., Davey, M.J., and O'Donnell, M. (2003) Mcm4, 6, 7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. J. Biol. Chem. 278, 49171-49182
21. Bochman, M. and Schwacha, A. (2007) Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and 5 define a slow ATP-dependent step. J. Biol. Chem. 282, 33759-33804
22. You, Z., Ishimi, Y., Masai, H., and Hanaoka, F. (2002) Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J. Biol. Chem. 277, 42471-42479
23. Ishimi, Y., Ichinose, S., Omori, A., Sato, K, and Kimura, H. (1996) Binding of human minichromosome maintenance proteins with histone H3. J. Biol. Chem. 271, 24115-24122
24. Yu, Z., Feng, D., and Liang, C. (2004) Pairwise interactions of the six human MCM protein subunits. J. Mol. Biol. 340, 1197-1206
25. Sakakibara, N, Kasiviswanathan, R., Melamud, E., Han, M., Schwarz, F.P., and Kelman, Z. (2008) Coupling of DNA binding and helicase activity is mediated by a conserved loop in the MCM protein. Nucleic Acids Res. 36, 1309-1320
26. Brewster, A.S., Wang, G, Yu, X., Greenleaf, W.B., Carazo, J.M., Tjajadi, M., Klein, M.G, and Chen, X.S. (2008) Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase. Proc. Natl Acad. Sci. USA 105, 20191-20196