Elevated serum fibroblast growth factor 21 levels in patients with hyperthyroidism

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 10, 2015, Pages 3800-3805

  Xiao, Fangsen ^a   Lin, Mingzhu ^a,b   Huang, Peiying ^a   Zeng, Jinyang ^a,b   Zeng, Xin ^a   Zhang, Huijie ^a   Li, Xiaoying ^a,b   Yang, Shuyu ^a,b   Li, Zhibin ^a,b,d   Li, Xuejun ^a,b,c  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b Xiamen Diabetes Institute   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; FIBROBLAST GROWTH FACTOR 21; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROXINE; TRIACYLGLYCEROL; ANTITHYROID AGENT; FIBROBLAST GROWTH FACTOR;

ADULT; AGE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BASAL METABOLIC RATE; BODY MASS; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENDER; HUMAN; HYPERTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; BLOOD; INSULIN RESISTANCE; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; ANTITHYROID AGENTS; CASE-CONTROL STUDIES; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; HYPERTHYROIDISM; INSULIN RESISTANCE; MALE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84943762353     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1797     Document Type: Article

References (18)

1. Lopez D, Abisambra Socarrás JF, Bedi M, Ness GC. Activation of the hepatic LDL receptor promoter by thyroid hormone. Biochim Biophys Acta. 2007;1771(9):1216-1225.
2. Ribeiro MO, Carvalho SD, Schultz JJ, et al. Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. J Clin Invest. 2001;108:97-105.
3. Laffitte BA, Chao LC, Li J, et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA. 2003;100:5419-5424.
4. Kharitonenkov A, Shiyanova TL, Koester A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005;115:1627-1635.
5. Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators-A critical appraisal. Cell Metab. 2012;16(6):693-705.
6. Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007;148:774-781.
7. Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149:6018-6027.
8. Adams AC, Astapova I, Fisher FM, et al. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPAR-dependent manner. J Biol Chem. 2010;285:14078-14082.
9. Domouzoglou EM, Fisher FM, Astapova I, et al. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology. 2014;155: 2031-2040.
10. Zhang A, Sieglaff DH, York JP, et al. Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver. J Endocrinol. 2015;224(3):289-301.
11. Gale AM, Gale CH. Estimation of the basal metabolic rate: from formulae based on pulse-rate and pulse pressure. The Lancet. 1931; 217(5624):1287-1288.
12. Bonde Y, Breuer O, Lütjohann D, Sjöberg S, Angelin B, Rudling M. Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans. J Lipid Res. 2014;55(11):2408-2415.
13. Ismail-Beigi F. Regulation of Na+,K(+)-ATPase expression by thyroid hormone. Semin Nephrol. 1992;12:44-48.
14. Lee JY, Takahashi N, Yasubuchi M, et al. Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. Am J Physiol Cell Physiol. 2012;302:C463-C472.
15. Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149(12):6018-6027.
16. Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1 and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26:271-281.
17. Lee P, Brychta RJ, Linderman J, Smith S, Chen KY, Celi FS. Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis. J Clin Endocrinol Metab. 2013;98(1):E98-E102.
18. Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Rydén M. FGF21 attenuates lipolysis in human adipocytes-A possible link to improved insulin sensitivity. FEBS Lett. 2008;582: 1725-1730.