Duodenal expression of 25 hydroxyVitamin D3-1α-hydroxylase is higher in adolescents than in children and adults

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 10, 2015, Pages 3668-3675

  Gawlik, Aneta ^a,b   Gepstein, Vardit ^a   Rozen, Nimrod ^c,f   Dahan, Aviva ^d   Ben Yosef, Dafna ^e   Wildbaum, Gizi ^f   Verbitsky, Oleg ^g   Shaoul, Ron ^a,f   Weisman, Yosef ^h   Tiosano, Dov ^a,f  

^a MEYER CHILDREN S HOSPITAL   (Israel)

^b MEDICAL UNIVERSITY OF SILESIA   (Poland)

^c Bone and Mineral Research Division HaEmeck Hospital   (Israel)

^d Gastroenterology Research Laboratory   (United States)

^e RAMBAM MEDICAL CENTER   (Israel)

^f TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^g ARIEL UNIVERSITY   (Israel)

^h TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; COLECALCIFEROL 24 HYDROXYLASE; CYTOCHROME P450 3A4; MESSENGER RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; PICROPODOPHYLLIN; PODOPHYLLOTOXIN;

ADOLESCENT; ADULT; AGE; ANIMAL TISSUE; ARTICLE; CHILD; CONTROLLED STUDY; DUODENUM; DUODENUM BIOPSY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITAMIN D METABOLISM; AGED; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD; SEXUAL MATURATION; YOUNG ADULT;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADOLESCENT; ADULT; AGE FACTORS; AGED; ANIMALS; CHILD; CHILD, PRESCHOOL; DUODENUM; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MIDDLE AGED; PODOPHYLLOTOXIN; RECEPTOR, IGF TYPE 1; SEXUAL MATURATION; YOUNG ADULT;

EID: 84943754229     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-1483     Document Type: Article

References (37)

1. Matkovic V. Calcium metabolism and calcium requirements during skeletal modeling and consolidation of bone mass. Am J Clin Nutr. 1991;54:245S-260S.
2. Abrams SA, Copeland KC, Gunn SK, GundbergCM,Klein KO, Ellis KJ. Calcium absorption, bone mass accumulation, and kinetics increase during early pubertal development in girls. J Clin Endocrinol Metab. 2000;85:1805-1809.
3. Matkovic V, Jelic T, Wardlaw GM, et al. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. J Clin Invest. 1994;93:799-808.
4. Bonjour JP, Theintz G, Buchs B, Slosman D, Rizzoli R. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 1991;73:555-563.
5. McCormick CC. Passive diffusion does not play a major role in the absorption of dietary calcium in normal adults. J Nutr. 2002;132: 3428-3430.
6. DeLuca HF. Overview of general physiologic features and functions of Vitamin D. Am J Clin Nutr. 2004;80:1689S-1696S.
7. Chesney RW, Rosen JF, Hamstra AJ, DeLuca HF. Serum 1,25-dihydroxyVitamin D levels in normal children and in Vitamin D disorders. Am J Dis Child. 1980;134:135-139.
8. Aksnes L, Aarskog D. Plasma concentrations of Vitamin D metabolites in puberty: effect of sexual maturation and implications for growth. J Clin Endocrinol Metab. 1982;55:94-101.
9. Ilich JZ, Badenhop NE, Jelic T, Clairmont AC, Nagode LA, Matkovic V. Calcitriol and bone mass accumulation in females during puberty. Calcif Tissue Int. 1997;61:104-109.
10. Taylor AF, Norman ME. Vitamin D metabolite levels in normal children. Pediatr Res. 1984;18:886-890.
11. Weaver CM, Martin BR, Plawecki KL, et al. Differences in calcium metabolism between adolescent and adult females. Am J Clin Nutr. 1995;61:577-581.
12. Lieben L, Masuyama R, Torrekens S, et al. Normocalcemia is maintained in mice under conditions of calcium malabsorption by Vitamin D-induced inhibition of bone mineralization. J Clin Invest. 2012;122:1803-1815.
13. Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyVitamin D(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86:888-894.
14. Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyVitamin D-1-hydroxylase. Arch Biochem Biophys. 2012;523:95-102.
15. Balesaria S, Sangha S, Walters JR. Human duodenum responses to Vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol. 2009; 297:G1193-G1197.
16. Liu N, Nguyen L, Chun RF, et al. Altered endocrine and autocrine metabolism of Vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 2008;149:4799-4808.
17. Bises G, Kallay E, Weiland T, et al. 25-hydroxyVitamin D3-1alphahydroxylase expression in normal and malignant human colon. J Histochem Cytochem. 2004;52:985-989.
18. Mapes B, Chase M, Hong E, et al. Ex vivo culture of primary human colonic tissue for studying transcriptional responses to 1alpha,25(OH)2 and 25(OH) Vitamin D. Physiol Genomics. 2014; 46:302-308.
19. Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol. 2011;347:97-105.
20. Mora S, Pitukcheewanont P, Nelson JC, Gilsanz V. Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children. J Clin Endocrinol Metab. 1999;84:2780-2783.
21. BootAM,EngelsMA,Boerma GJ, Krenning EP, De Muinck Keizer-Schrama SM. Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency. J Clin Endocrinol Metab. 1997;82: 2423-2428.
22. Fatayerji D, Mawer EB, Eastell R. The role of insulin-like growth factor I in age-related changes in calcium homeostasis in men. J Clin Endocrinol Metab. 2000;85:4657-4662.
23. Zoidis E, Gosteli-Peter M, Ghirlanda-Keller C, Meinel L, Zapf J, Schmid C. IGF-I andGHstimulate PhexmRNAexpression in lungs and bones and 1,25-dihydroxyVitamin D(3) production in hypophysectomized rats. Eur J Endocrinol. 2002;146:97-105.
24. Wong MS, Tembe VA, Favus MJ. Insulin-like growth factor-I stimulates renal 1, 25-dihydroxycholecalciferol synthesis in old rats fed a low calcium diet. J Nutr. 2000;130:1147-1152.
25. Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O, Axelson M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004;64:236-242.
26. Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M, Larsson O. The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene. 2004;23:7854-7862.
27. Qi L, Toyoda H, Shankar V, et al. Heterogeneity of neuroblastoma cell lines in insulin-like growth factor 1 receptor/Akt pathway-mediated cell proliferative responses. Cancer Sci. 2013;104:1162-1171.
28. Vasilcanu R, Vasilcanu D, Rosengren L, et al. Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1. Oncogene. 2008;27:1629-1638.
29. Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995;13:129-134.
30. Watkins PB. The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Deliv Rev. 1997;27:161-170.
31. Bareis P, Kallay E, Bischof MG, et al. Clonal differences in expression of 25-hydroxyVitamin D(3)-1alpha-hydroxylase, of 25-hydroxyVitamin D(3)-24-hydroxylase, and of the Vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyVitamin D(3). Exp Cell Res. 2002;276: 320-327.
32. Fakhoury M, Litalien C, Medard Y, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos. 2005;33:1603-1607.
33. Xu Y, Hashizume T, Shuhart MC, et al. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyVitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006;69:56-65.
34. Juul A, Bang P, Hertel NT, et al. Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab. 1994;78:744-752.
35. Liel Y, Shany S, Smirnoff P, Schwartz B. Estrogen increases 1,25-dihydroxyvitaminDreceptors expression and bioresponse in the rat duodenal mucosa. Endocrinology. 1999;140:280-285.
36. Lechner D, Bajna E, Adlercreutz H, Cross HS. Genistein and 17betaestradiol, but not equol, regulate Vitamin D synthesis in human colon and breast cancer cells. Anticancer Res. 2006;26:2597-2603.
37. Van Cromphaut SJ, Rummens K, Stockmans I, et al. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitaminDreceptor-independent mechanisms. J Bone Miner Res. 2003;18:1725-1736.