-
3
-
-
84943747244
-
-
R & D costs are on the rise. (News). (new drug development) (Brief Article) HighBeam Research. Date of access: 14/03/2015
-
R & D costs are on the rise. (News). (new drug development) (Brief Article)." Medical Marketing & Media. Haymarket Media. 2003. HighBeam Research. Date of access: 14/03/2015.
-
(2003)
Medical Marketing & Media. Haymarket Media
-
-
-
4
-
-
0036591838
-
Engineering cellular microenvironments to improve cell-based drug testing
-
Bhadriraju, K., Chen, C. S. Engineering cellular microenvironments to improve cell-based drug testing. Drug Discovery Today 11, 612-620 (2002).
-
(2002)
Drug Discovery Today
, vol.11
, pp. 612-620
-
-
Bhadriraju, K.1
Chen, C.S.2
-
5
-
-
34648834682
-
The third dimension bridges the gap between cell culture and live tissue
-
Pampaloni, F., Reynaud, E. G., Stelzer, E. H. K. The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8, 839-845 (2007).
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 839-845
-
-
Pampaloni, F.1
Reynaud, E.G.2
Stelzer, E.H.K.3
-
6
-
-
84887012341
-
Microfabrication of human organs-on-chips
-
Huh, D. et al. Microfabrication of human organs-on-chips. Nat. Protocols 8, 2135-2157, doi: 10.1038/nprot.2013.137 (2013).
-
(2013)
Nat. Protocols
, vol.8
, pp. 2135-2157
-
-
Huh, D.1
-
7
-
-
84856441579
-
Biomimetic tissues on a chip for drug discovery
-
Ghaemmaghami, A. M., Hancock, M. J., Harrington, H., Kaji, H., Khademhosseini, A. Biomimetic tissues on a chip for drug discovery. Drug Discovery Today 17, 173-181, doi: http://dx.doi.org/10.1016/j.drudis.2011.10.029 (2012).
-
(2012)
Drug Discovery Today
, vol.17
, pp. 173-181
-
-
Ghaemmaghami, A.M.1
Hancock, M.J.2
Harrington, H.3
Kaji, H.4
Khademhosseini, A.5
-
8
-
-
84891351524
-
Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing
-
Truskey, G. A. et al. Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing. Stem Cell Research & Therapy 4, S10-S10, doi: 10.1186/scrt371 (2013).
-
(2013)
Stem Cell Research & Therapy
, vol.4
, pp. S10-S10
-
-
Truskey, G.A.1
-
9
-
-
84902550109
-
Microfluidic techniques for development of 3D vascularized tissue
-
Hasan, A. et al. Microfluidic techniques for development of 3D vascularized tissue. Biomaterials 35, 7308-7325, doi: http://dx.doi.org/10.1016/j.biomaterials.2014.04.091 (2014).
-
(2014)
Biomaterials
, vol.35
, pp. 7308-7325
-
-
Hasan, A.1
-
10
-
-
33644659963
-
Biomarkers and mechanisms of drug-induced vascular injury in non-rodents
-
Louden C, B. D. et al. Biomarkers and mechanisms of drug-induced vascular injury in non-rodents. Toxicologic Pathology 34, 19-26 (2006).
-
(2006)
Toxicologic Pathology
, vol.34
, pp. 19-26
-
-
Louden, C.B.D.1
-
11
-
-
78649953975
-
Biomarkers of endothelial cell activation serve as potential surrogate markers for druginduced vascular injury
-
Zhang J. D. A., Hanig, J. P., Colatsky, T. Biomarkers of endothelial cell activation serve as potential surrogate markers for druginduced vascular injury. Toxicologic Pathology 38, 856-871 (2010).
-
(2010)
Toxicologic Pathology
, vol.38
, pp. 856-871
-
-
Zhang, J.D.A.1
Hanig, J.P.2
Colatsky, T.3
-
12
-
-
84864204529
-
Microfluidic models of vascular functions
-
Won, K. H. K., Chan, J. M., Kamm, R. D., Tien, J. Microfluidic Models of Vascular Functions. Annual Review of Biomedical Engineering 14, 205-230 (2012).
-
(2012)
Annual Review of Biomedical Engineering
, vol.14
, pp. 205-230
-
-
Won, K.H.K.1
Chan, J.M.2
Kamm, R.D.3
Tien, J.4
-
13
-
-
84865207552
-
Three-dimensional electrospun poly (lactide-co-?-caprolactone) for small-diameter vascular grafts
-
Mun, Cho Hay et al. Three-dimensional electrospun poly (lactide-co-?-caprolactone) for small-diameter vascular grafts. Tissue Engineering Part A 18, 1608-1616 (2012).
-
(2012)
Tissue Engineering Part A
, vol.18
, pp. 1608-1616
-
-
Cho Hay, M.1
-
14
-
-
84888644567
-
Electrospun scaffolds for tissue engineering of vascular grafts
-
Hasan, A. et al. Electrospun scaffolds for tissue engineering of vascular grafts. Acta Biomaterialia 10, 11-25, doi: http://dx.doi.org/10.1016/j.actbio.2013.08.022 (2014).
-
(2014)
Acta Biomaterialia
, vol.10
, pp. 11-25
-
-
Hasan, A.1
-
15
-
-
33644816362
-
Human tissue-engineered blood vessels for adult arterial revascularization
-
L'Heureux, N. et al. Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med 12, 361-365 (2006).
-
(2006)
Nat Med
, vol.12
, pp. 361-365
-
-
L'Heureux, N.1
-
16
-
-
0035099520
-
Morphologic and mechanical characteristics of engineered bovine arteries
-
Niklason, L. E. et al. Morphologic and mechanical characteristics of engineered bovine arteries. Journal of Vascular Surgery 33, 628-638, doi: http://dx.doi.org/10.1067/mva.2001.111747 (2001).
-
(2001)
Journal of Vascular Surgery
, vol.33
, pp. 628-638
-
-
Niklason, L.E.1
-
17
-
-
2642619407
-
A completely biological tissue-engineered human blood vessel
-
L'Heureux, N. P. S., Labbe, R., Germain, L., Auger, F. A. A completely biological tissue-engineered human blood vessel. The FASEB Journal 12, 47-56 (1988).
-
(1988)
The FASEB Journal
, vol.12
, pp. 47-56
-
-
L'Heureux, N.P.S.1
Labbe, R.2
Germain, L.3
Auger, F.A.4
-
18
-
-
84856003997
-
A novel strategy to engineer small-diameter vascular grafts from marrow-derived mesenchymal stem cells
-
Zhao J. et al. A novel strategy to engineer small-diameter vascular grafts from marrow-derived mesenchymal stem cells. Artificial Organs 36, 93-101 (2012).
-
(2012)
Artificial Organs
, vol.36
, pp. 93-101
-
-
Zhao, J.1
-
19
-
-
44949238649
-
Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs)
-
Gong, Z., Niklason, L. E. Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs). The FASEB Journal 22, 1635-1648 (2008).
-
(2008)
The FASEB Journal
, vol.22
, pp. 1635-1648
-
-
Gong, Z.1
Niklason, L.E.2
-
20
-
-
84913616783
-
Endothelial Cells Direct Mesenchymal Stem Cells Toward a Smooth Muscle Cell Fate
-
Cho-Hao, L., Brenda, L. Endothelial Cells Direct Mesenchymal Stem Cells Toward a Smooth Muscle Cell Fate. Stem Cells and Development 23, 2581-2590 (2014).
-
(2014)
Stem Cells and Development
, vol.23
, pp. 2581-2590
-
-
Cho-Hao, L.1
Brenda, L.2
-
21
-
-
84891409244
-
Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems
-
Hong, S. et al. Magnetoactive sponges for dynamic control of microfluidic flow patterns in microphysiological systems. Lab on a chip 14, 514-521, doi: 10.1039/c3lc51076j (2014).
-
(2014)
Lab on A Chip
, vol.14
, pp. 514-521
-
-
Hong, S.1
-
22
-
-
77952011901
-
Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer
-
Zhao, F. et al. Low oxygen tension and synthetic nanogratings improve the uniformity and stemness of human mesenchymal stem cell layer. Mol Ther 18, 1010-1018, doi: 10.1038/mt.2010.21 (2010).
-
(2010)
Mol Ther
, vol.18
, pp. 1010-1018
-
-
Zhao, F.1
-
23
-
-
3042817994
-
Perfusion bioreactor for small diameter tissue-engineered arteries
-
Chrysanthi Williams, T. M. W. Perfusion Bioreactor for Small Diameter Tissue-Engineered Arteries. Tissue Engineering 10, 930-941 (2004).
-
(2004)
Tissue Engineering
, vol.10
, pp. 930-941
-
-
Chrysanthi Williams, T.M.W.1
-
24
-
-
0034980050
-
Tissue engineering of small caliber vascular grafts
-
Hoerstrup, S. P. et al. Tissue engineering of small caliber vascular grafts. European Journal of Cardio-Thoracic Surgery 20, 164-169, doi: 10.1016/s1010-7940(01)00706-0 (2001).
-
(2001)
European Journal of Cardio-Thoracic Surgery
, vol.20
, pp. 164-169
-
-
Hoerstrup, S.P.1
-
25
-
-
58249084560
-
Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery
-
Konig, G. et al. Mechanical properties of completely autologous human tissue engineered blood vessels compared to human saphenous vein and mammary artery. Biomaterials 30, 1542-1550, doi: http://dx.doi.org/10.1016/j.biomaterials.2008.11.011 (2009).
-
(2009)
Biomaterials
, vol.30
, pp. 1542-1550
-
-
Konig, G.1
-
26
-
-
0025047567
-
Endothelium-dependent flow-induced dilation of isolated coronary arterioles
-
Kuo, L. D. M., Chilian, W. M. Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. American Journal of Physiology 259, H1063-1070 (1990).
-
(1990)
American Journal of Physiology
, vol.259
, pp. H1063-1070
-
-
Kuo, L.D.M.1
Chilian, W.M.2
-
27
-
-
64749090979
-
ENOS Activation by physical forces: From short-term regulation of contraction to chronic remodeling of cardiovascular tissues
-
Balligand, J.-L., Feron, O., Dessy, C. eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues. Physiological Reviews 89, 481-534 (2009).
-
(2009)
Physiological Reviews
, vol.89
, pp. 481-534
-
-
Balligand, J.-L.1
Feron, O.2
Dessy, C.3
-
28
-
-
0036181723
-
Karlon. Fluid shear stress-induced alignment of cultured vascular smooth muscle cells
-
Lee, Ann A., Sheila Dela Cruz, D. A. G., Ratcliffe, Anthony & William J. Karlon. Fluid shear stress-induced alignment of cultured vascular smooth muscle cells. Journal of Biomechanical Engineering 124, 37-43 (2002).
-
(2002)
Journal of Biomechanical Engineering
, vol.124
, pp. 37-43
-
-
Lee Ann, A.1
Sheila Dela Cruz, D.A.G.2
Anthony, R.3
William, J.4
-
29
-
-
79960214253
-
Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells
-
Cao, L., Wu, A., Truskey, G. A. Biomechanical effects of flow and coculture on human aortic and cord blood-derived endothelial cells. Journal of Biomechanics 44, 2150-2157, doi: http://dx.doi.org/10.1016/j.jbiomech.2011.05.024 (2011).
-
(2011)
Journal of Biomechanics
, vol.44
, pp. 2150-2157
-
-
Cao, L.1
Wu, A.2
Truskey, G.A.3
-
30
-
-
40849094515
-
Foreign body reaction to biomaterials
-
Anderson, J. M., Rodriguez, A., Chang, D. T. Foreign body reaction to biomaterials. Seminars in Immunology 20, 86-100, doi: http://dx.doi.org/10.1016/j.smim.2007.11.004 (2008).
-
(2008)
Seminars in Immunology
, vol.20
, pp. 86-100
-
-
Anderson, J.M.1
Rodriguez, A.2
Chang, D.T.3
-
31
-
-
42749096667
-
On the mechanisms of biocompatibility
-
Williams, D. F. On the mechanisms of biocompatibility. Biomaterials 29, 2941-2953, doi: http://dx.doi.org/10.1016/j. biomaterials.2008.04.023 (2008).
-
(2008)
Biomaterials
, vol.29
, pp. 2941-2953
-
-
Williams, D.F.1
-
32
-
-
69249208450
-
Scaffold-free vascular tissue engineering using bioprinting
-
Norotte, C., Marga, F. S., Niklason, L. E., Forgacs, G. Scaffold-free vascular tissue engineering using bioprinting. Biomaterials 30, 5910-5917, doi: http://dx.doi.org/10.1016/j.biomaterials.2009.06.034 (2009).
-
(2009)
Biomaterials
, vol.30
, pp. 5910-5917
-
-
Norotte, C.1
Marga, F.S.2
Niklason, L.E.3
Forgacs, G.4
-
33
-
-
0030330268
-
Flow-induced vasodilation of the human brachial artery is impaired in patients 40 years of age with coronary artery disease
-
Lieberman, E. H. et al. Flow-induced vasodilation of the human brachial artery is impaired in patients Celermajer, D. S. et al.Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis.Lancet7,1111-1115 (1992
-
(1996)
The American Journal of Cardiology
, vol.78
, pp. 1210-1214
-
-
Lieberman, E.H.1
-
34
-
-
0026478022
-
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
-
Celermajer, D. S. et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 7, 1111-1115 (1992).
-
(1992)
Lancet
, vol.7
, pp. 1111-1115
-
-
Celermajer, D.S.1
-
35
-
-
0028957394
-
Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo
-
Joannides, R. et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 5, 131409 (1995).
-
(1995)
Circulation
, vol.5
, pp. 131409
-
-
Joannides, R.1
-
36
-
-
79251596824
-
Vascular smooth muscle enhances functionality of tissue-engineered blood vessels in vivo
-
Neff, L. P. et al. Vascular smooth muscle enhances functionality of tissue-engineered blood vessels in vivo. Journal of Vascular Surgery 53, 426-434, doi: http://dx.doi.org/10.1016/j.jvs.2010.07.054 (2011).
-
(2011)
Journal of Vascular Surgery
, vol.53
, pp. 426-434
-
-
Neff, L.P.1
-
37
-
-
0028243619
-
Endothelial-leukocyte adhesion molecules in human disease
-
Bevilacqua, M. P., Mannori, N. R., Cecconi, G. O. Endothelial-leukocyte adhesion molecules in human disease. Annual Review of Medicine 45, 361-378 (1994).
-
(1994)
Annual Review of Medicine
, vol.45
, pp. 361-378
-
-
Bevilacqua, M.P.1
Mannori, N.R.2
Cecconi, G.O.3
-
38
-
-
0025858684
-
Human endothelial cells: Effect of TNF-alpha on peripheral blood mononuclear cell adhesion
-
Ikuta, S., Shenton, K. J., Givan, B. K., Lennard, A. L. T. W. Human endothelial cells: effect of TNF-alpha on peripheral blood mononuclear cell adhesion. Immunology 73, 71-76 (1991).
-
(1991)
Immunology
, vol.73
, pp. 71-76
-
-
Ikuta, S.1
Shenton, K.J.2
Givan, B.K.3
Lennard, A.L.T.W.4
-
39
-
-
84860374513
-
Nanotopography as modulator of human mesenchymal stem cell function
-
Kulangara, K., Yang, Y., Yang, J., Leong, K. W. Nanotopography as modulator of human mesenchymal stem cell function. Biomaterials 33, 4998-5003, doi:10.1016/j.biomaterials.2012.03.053 (2012).
-
(2012)
Biomaterials
, vol.33
, pp. 4998-5003
-
-
Kulangara, K.1
Yang, Y.2
Yang, J.3
Leong, K.W.4
-
40
-
-
84899488674
-
The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons
-
Kulangara, K. et al. The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons. Biomaterials 35, 5327-5336, doi:10.1016/j.biomaterials.2014.03.034 (2014).
-
(2014)
Biomaterials
, vol.35
, pp. 5327-5336
-
-
Kulangara, K.1
-
41
-
-
72649088994
-
Characterization of umbilical cord blood-derived late outgrowth endothelial progenitor cells exposed to laminar shear stress
-
Melissa A. Brown, C. S. W., Mathew Angelos, George A. Truskey. Characterization of Umbilical Cord Blood-Derived Late Outgrowth Endothelial Progenitor Cells Exposed to Laminar Shear Stress. Tissue Engineering Part A 15, 3575-3587 (2009).
-
(2009)
Tissue Engineering Part A
, vol.15
, pp. 3575-3587
-
-
Melissa, A.1
Brown, C.S.W.2
Angelos, M.3
Truskey, G.A.4
|