Structural Genomics Support for Infectious Disease Drug Design

ACS Infectious Diseases

Volumn 1, Issue 3, 2016, Pages 127-129

  Stacy, Robin ^a   Anderson, Wayne F ^b,c   Myler, Peter J ^a,d  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Center for Structural Genomics of Infectious Diseases (CSGID)   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FK 506 BINDING PROTEIN; PIPECOLIC ACID DERIVATIVE;

CYTOTOXICITY; DRUG DESIGN; ESCHERICHIA COLI; HUMAN; INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTEIN METABOLISM; PROTEIN STRUCTURE; SHORT SURVEY; STRUCTURAL GENOMICS;

EID: 84943644705     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/id500048p     Document Type: Short Survey

References (9)

1. Baugh, L., Phan, I., Begley, D. W., Clifton, M. C., Armour, B., Dranow, D., Taylor, B. M., Muruthi, M. M., Abendroth, J., and Fairman, J. W. (2014) Increasing the structural coverage of tuberculosis drug targets Tuberculosis 10.1016/j.tube.2014.12.003
2. Norville, I. H., O'Shea, K., Sarkar-Tyson, M., Zheng, S., Titball, R. W., Varani, G., and Harmer, N. J. The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem. J. 2011, 437, 413-422, DOI: 10.1042/BJ20110345 BJ20110345 [pii].
3. Juli, C., Sippel, M., Jäger, J., Thiele, A., Weiwad, M., Schweimer, K., Rösch, P., Steinert, M., Sotriffer, C. A., and Holzgrabe, U. (2011) Pipecolic acid derivatives as small-molecule inhibitors of the legionella MIP protein J. Med. Chem. 54, 277-283 10.1021/jm101156y
4. Begley, D. W., Fox, D., 3rd, Jenner, D., Juli, C., Pierce, P. G., Abendroth, J., Muruthi, M., Safford, K., Anderson, V., and Atkins, K.; et al., A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob. Agents Chemother. 2014, 58, 1458-1467 DOI: 10.1128/AAC.01875-13 AAC.01875-13 [pii].
5. Makowska-Grzyska, M., Kim, Y., Wu, R., Wilton, R., Gollapalli, D. R., Wang, X. K., Zhang, R., Jedrzejczak, R., Mack, J. C., and Maltseva, N. et al. 2012, Bacillus anthracis inosine 5′-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes Biochemistry 51, 6148-6163 10.1021/bi300511w
6. Gorla, S. K., Kavitha, M., Zhang, M., Chin, J. E. W., Liu, X., Striepen, B., Makowska-Grzyska, M., Kim, Y., Joachimiak, A., and Hedstrom, L. et al. 2013, Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5′-monophosphate dehydrogenase J. Med. Chem. 56, 4028-4043 10.1021/jm400241j
7. Sun, Z., Khan, J., and Makowska-Grzyska, M. et al., Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3]pyrazole Cryptosporidium parvum inosine 5′-monophsphate dehydrogenase (CpIMPDH) inhibitors. J. Med. Chem. 2014, 57, 10544-10550, DOI: 10.1021/jm501527z.
8. Lou, K.-J. SciBX Translational Note, 2013; http://www.nature.com/scibx/journal/v6/n18/full/sc.
9. Mitchell, L. SDDC Neglected Diseases press release, 2014; http://www.eurekalert.org/pub-releases/2014-11/uot.