MiR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3

Molecular Medicine Reports

Volumn 12, Issue 5, 2015, Pages 7102-7108

  Huang, Jian ^a   Jiao, Junhua ^a   Xu, Weihua ^a   Zhao, Huayang ^a   Zhang, Chunxiao ^a   Shi, Yan ^a   Xiao, Zhijian ^a  

^a The First Affliated Hospital of Xinxiang Medical University   (China)

Author keywords

FOXO3; MicroRNA 155; Monocyte; Tuberculosis

Indexed keywords

CD14 ANTIGEN; LUCIFERASE; MICRORNA; MICRORNA 155; TRANSCRIPTION FACTOR FKHRL1; 3' UNTRANSLATED REGION; ANTISENSE OLIGONUCLEOTIDE; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; MIRN155 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; LUNG TUBERCULOSIS; MALE; MONOCYTE; MONOCYTE MACROPHAGE PRECURSOR CELL; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; RANDOMIZED CONTROLLED TRIAL; UPREGULATION; WILD TYPE; ACUTE DISEASE; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL LINE; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; SEQUENCE ALIGNMENT; TUBERCULOSIS;

3' UNTRANSLATED REGIONS; ACUTE DISEASE; ADULT; AGED; ANTIGENS, CD14; APOPTOSIS; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL LINE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MONOCYTES; OLIGONUCLEOTIDES, ANTISENSE; SEQUENCE ALIGNMENT; TUBERCULOSIS; UP-REGULATION;

EID: 84943612977     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4250     Document Type: Article

References (30)

1. WHO: Global tuberculosis report. World Health Organization, France: 1-89, 2012.
2. Cooper AM: Cell-mediated immune responses in tuberculosis. Annu Rev Immunol 27: 393-422, 2009.
3. Natarajan K, Kundu M, Sharma P and Basu J: Innate immune responses to M. tuberculosis infection. Tuberculosis (Edinb) 91: 427-431, 2011.
4. Smith I: Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 16: 463-496, 2003.
5. Russell DG, Barry CE III and Flynn JL: Tuberculosis: What we don't know can and does, hurt us. Science 328: 852-856, 2010.
6. Riendeau CJ and Kornfeld H: THP-1 cell apoptosis in response to Mycobacterial infection. Infect Immun 71: 254-259, 2003.
7. Khalilullah SA, Harapan H, Hasan N, Winardi W, Ichsan I and Mulyadi M: Host genome polymorphisms and tuberculosis infection: What we have to say? Egyptian Journal of Chest Diseases and Tuberculosis 63: 173-85, 2014.
8. Akita T, Takuno S and Innan H: Modeling evolutionary growth of a microRNA-mediated regulation system. J Theor Biol 311: 54-65, 2012.
9. Kanwar JR, Mahidhara G and Kanwar RK: MicroRNA in human cancer and chronic inflammatory diseases. Front Biosci (Schol Ed) 2: 1113-1126, 2010.
10. Chen XM: MicroRNA signatures in liver diseases. World J Gastroenterol 15: 1665-1672, 2009.
11. Christensen M and Schratt GM: MicroRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases. Neurosci Lett 466: 55-62, 2009.
12. Pauley KM, Cha S and Chan EK: MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun 32: 189-194, 2009.
13. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, et al: Requirement of bic/microRNA-155 for normal immune function. Science 316: 608-611, 2007.
14. Curtale G, Citarella F, Carissimi C, Goldoni M, Carucci N, Fulci V, Franceschini D, Meloni F, Barnaba V and Macino G: An emerging player in the adaptive immune response: MicroRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood 115: 265-273, 2010.
15. Liu Y, Wang X, Jiang J, Cao Z, Yang B and Cheng X: Modulation of T cell cytokine production by miR-144∗ with elevated expression in patients with pulmonary tuberculosis. Mol Immunol 48: 1084-1090, 2011.
16. Marin ND, Paris SC, Rojas M and Garcia LF: Reduced frequency of memory T cells and increased Th17 responses in patients with active tuberculosis. Clin Vaccine Immunol 19: 1667-1676, 2012.
17. Tsitsiou E and Lindsay MA: MicroRNAs and the immune response. Curr Opin Pharmacol 9: 514-520, 2009.
18. Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, et al: miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity 41: 605-619, 2014.
19. Rajaram MV, Ni B, Morris JD, Brooks MN, Carlson TK, Bakthavachalu B, Schoenberg DR, Torrelles JB and Schlesinger LS: Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci USA 108: 17408-17413, 2011.
20. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P and Szabo G: Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem 286: 1436-1444, 2011.
21. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868, 1999.
22. Arden KC: FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 27: 2345-2350, 2008.
23. Peng SL: Foxo in the immune system. Oncogene 27: 2337-2344, 2008.
24. Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M and Bernard A: Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a. Oncogene 26: 7081-7091, 2007.
25. Haoues M, Refai A, Mallavialle A, Barbouche MR, Laabidi N, Deckert M and Essafi M: Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG-infected macrophages. Cell Microbiol 16: 1378-1390, 2014.
26. Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA and Liu YC: Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207: 1381-1391, 2010.
27. Ling N, Gu J, Lei Z, Li M, Zhao J, Zhang HT and Li X: MicroRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma. Oncol Rep 30: 2111-2118, 2013.
28. Zhang L, Liu S, Zhang L, You H, Huang R, Sun L, He P, Chen S, Zhang H and Xie P: Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. Int J Mol Sci 15: 21825-21839, 2014.
29. Liu Y, Jiang J, Wang X, Zhai F and Cheng X: MiR-582-5p is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO1. PloS One 8: e78381, 2013.
30. Wu J, Lu C, Diao N, et al: Analysis of microRNA expression profiling identifies miR-155 and miR-155∗ as potential diagnostic markers for active tuberculosis: A preliminary study. Hum Immunol 73: 31-37, 2012.