Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

Journal of Neurochemistry

Volumn 135, Issue 2, 2015, Pages 347-356

  Liu, Junli ^a,b   Tian, Daishi ^a,b   Murugan, Madhuvika ^b   Eyo, Ukpong B ^b   Dreyfus, Cheryl F ^c   Wang, Wei ^a   Wu, Long Jun ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

cuprizone; demyelination; microglia; multiple sclerosis; oligodendrocytes; voltage gated proton channel Hv1

Indexed keywords

ION CHANNEL; MYELIN BASIC PROTEIN; PROTEIN HV1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CHELATING AGENT; CUPRIZONE; HV1 PROTON CHANNEL, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DEMYELINATION; MALE; MICROGLIA; MOLECULAR PATHOLOGY; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANIMAL; BODY EQUILIBRIUM; C57BL MOUSE; CHEMICALLY INDUCED; DEMYELINATING DISEASE; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; METABOLISM; NEURAL STEM CELL; PATHOLOGY;

ANIMALS; CHELATING AGENTS; CUPRIZONE; DEMYELINATING DISEASES; ION CHANNELS; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; NADPH OXIDASE; NEURAL STEM CELLS; OXIDATIVE STRESS; POSTURAL BALANCE; REACTIVE OXYGEN SPECIES;

EID: 84943581694     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13242     Document Type: Article

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