Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: A randomised controlled clinical trial

Heart

Volumn 101, Issue 3, 2015, Pages 185-192

  Candilio, Luciano ^a   Malik, Abdul ^a   Ariti, Cono ^b   Barnard, Matthew ^c   Di Salvo, Carmelo ^c   Lawrence, David ^c   Hayward, Martin ^c   Yap, John ^c   Roberts, Neil ^c   Sheikh, Amir ^c   Kolvekar, Shyam ^c   Hausenloy, Derek J ^a   Yellon, Derek M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Health Education England   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CREATINE KINASE; DOBUTAMINE; DOPAMINE; DOPEXAMINE; ENOXIMONE; GLYCERYL TRINITRATE; ISOPRENALINE; MILRINONE; NORADRENALIN; TROPONIN T; BIOLOGICAL MARKER; TROPONIN I;

ACUTE KIDNEY FAILURE; ADULT; ANGINA PECTORIS; ARTICLE; BACTERIAL ENDOCARDITIS; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY RECANALIZATION; DOUBLE BLIND PROCEDURE; ELECTIVE SURGERY; ENZYME RELEASE; FEMALE; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART MUSCLE INJURY; HEART VALVE SURGERY; HOSPITALIZATION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; INTRAOPERATIVE PERIOD; ISCHEMIC PRECONDITIONING; KIDNEY FUNCTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MUSCLE INJURY; PERIOPERATIVE MYOCARDIAL INJURY; PEROPERATIVE COMPLICATION; POST HOC ANALYSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REMOTE ISCHEMIC PRECONDITIONING; SKELETAL MUSCLE; VALVULAR HEART DISEASE; AGED; BLOOD; CLINICAL TRIAL; CORONARY ARTERY DISEASE; HEART INFARCTION PREVENTION; MULTICENTER STUDY; MYOCARDIAL REPERFUSION INJURY; PREOPERATIVE CARE; PROCEDURES; TREATMENT OUTCOME;

AGED; BIOMARKERS; CORONARY ARTERY BYPASS; CORONARY ARTERY DISEASE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIAL REPERFUSION INJURY; PREOPERATIVE CARE; TREATMENT OUTCOME; TROPONIN I; TROPONIN T;

EID: 84920895937     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2014-306178     Document Type: Article

References (30)

1. Muehlschlegel JD, Perry TE, Liu KY, et al. Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically signifi cant myocardial injury after coronary artery bypass grafting. Eur Heart J 2009;30:1574-83.
2. Przyklenk K, Bauer B, Ovize M, et al. Regional ischaemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 1993;87:893-9.
3. Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res 2008;79:377-86.
4. Hausenloy DJ, Mwamure PK, Venugopal V, et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlle. Lancet 2007;370:575-9.
5. Thielmann M, Kottenberg E, Boengler K, et al. Remote ischaemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest. Basic Res Cardiol 2010;105:657-64.
6. Rahman IA, Mascaro JG, Steeds RP, et al. Remote ischaemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation 2010;122(11 Suppl):S53-9.
7. Venugopal V, Hausenloy DJ, Ludman A, et al. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing cardiac surgery with cold-blood cardioplegia: a randomised controlled trial. Heart 2009;95:1567-71.
8. Ali N, Rizwi F, Iqbal A, et al. Induced remote ischaemic pre-conditioning on ischaemia-reperfusion injury in patients undergoing coronary artery bypass. J Coll Physicians Surg Pak 2010;20:427-31.
9. Hong DM, Jeon Y, Lee CS, et al. Effects of remote ischaemic preconditioning with postconditioning in patients undergoing off-pump coronary artery bypass surgery-randomized controlled trial. Circ J 2012;76:884-90.
10. Young PJ, Dalley P, Garden A, et al. A pilot study investigating the effects of remote ischaemic preconditioning in high-risk cardiac surgery using a randomised controlled double-blind protocol. Basic Res Cardiol 2012;107:256.
11. Choi YS, Shim JK, Kim JC, et al. Effect of remote ischaemic preconditioning on renal dysfunction after complex valvular heart surgery: a randomized controlled trial. J Thorac Cardiovasc Surg 2011;142:148-54.
12. Lomivorotov VV, Shmyrev VA, Nepomnyaschih VA, et al. Remote ischaemic preconditioning does not protect the heart in patients undergoing coronary artery bypass grafting. Interact Cardiovasc Thorac Surg 2012;15:18-22.
13. Xie JJ, Liao XL, Chen WG, et al. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial. Heart 2012;98:384-8.
14. Li L, Luo W, Huang L, et al. Remote perconditioning reduces myocardial injury in adult valve replacement: a randomized controlled trial. J Surg Res 2010;164:e21-6.
15. Cheung MM, Kharbanda RK, Konstantinov IE, et al. Randomized controlled trial of the effects of remote ischaemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol 2006;47:2277-82.
16. Zhou W, Zeng D, Chen R, et al. Limb ischaemic preconditioning reduces heart and lung injury after an open heart operation in infants. Pediatr Cardiol 2010;31:22-9.
17. Karuppasamy P, Chaubey S, Dew T, et al. Remote intermittent ischaemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol 2011;106:511-19.
18. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004;8:R204-12.
19. Ko WJ, Lin CY, Chen RJ, et al. Extracorporeal membrane oxygenation support for adult postcardiotomy cardiogenic shock. Ann Thorac Surg 2002;73:538-45.
20. Pilcher JM, Young P, Weatherall M, et al. A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery. J R Soc Med 2012;105:436-45.
21. Kleinbongard P, Thielmann M, Jakob H, et al. Nitroglycerin does not interfere with protection by remote ischaemic preconditioning in patients with surgical coronary revascularization under isoflurane anesthesia. Cardiovasc Drugs Ther 2013;27:359-61.
22. Hill M, Takano H, Tang XL, et al. Nitroglycerin induces late preconditioning against myocardial infarction in conscious rabbits despite development of nitrate tolerance. Circulation 2001;104:694-9.
23. Heusch G, Boengler K, Schulz R. Cardioprotection: nitric oxide, protein kinases, and mitochondria. Circulation 2008;118:1915-19.
24. Crystal E, Garfinkle MS, Connolly SS, et al. Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev 2004;(4):CD003611.
25. Brevoord D, Hollmann MW, De Hert SG, et al. Effect of remote ischaemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial). BMC Anesthesiol 2011;11:11.
26. Rosner MH, Okusa MD. Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 2006;1:19-32.
27. Venugopal V, Laing CM, Ludman A, et al. Effect of remote ischaemic preconditioning on acute kidney injury in nondiabetic patients undergoing coronary artery bypass graft surgery: a secondary analysis of 2 small randomized trials. Am J Kidney Dis 2010;56:1043-9.
28. Zimmerman RF, Ezeanuna PU, Kane JC, et al. Ischemic preconditioning at a remote site prevents acute kidney injury in patients following cardiac surgery. Kidney Int 2011;80:861-7.
29. Hausenloy DJ, Candilio L, Laing C, et al. Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial. Clin Res Cardiol 2012;101:339-48.
30. Meybohm P, Zacharowski K, Cremer J, et al. Remote ischaemic preconditioning for heart surgery. The study design for a multi-center randomized double-blinded controlled clinical trial-the RIPHeart-Study. Eur Heart J 2012;33:1423-6.