Type-II NADH: Quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction

Molecular Microbiology

Volumn 98, Issue 2, 2015, Pages 272-288

  Sena, Filipa V ^a   Batista, Ana P ^a   Catarino, Teresa ^a,b   Brito, José A ^a   Archer, Margarida ^a   Viertler, Martin ^c,d   Madl, Tobias ^c,d   Cabrita, Eurico J ^b   Pereira, Manuela M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TYPE II NADH QUINONE OXIDOREDUCTASE; UNCLASSIFIED DRUG; 2-(N-HEPTYL)-4-HYDROXYQUINOLINE N-OXIDE; BACTERIAL PROTEIN; QUINOLINOL DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE);

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN INTERACTION; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; STEADY STATE; STRUCTURE ANALYSIS; SURFACE CHARGE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; ELECTRON TRANSPORT; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN MULTIMERIZATION; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ELECTRON TRANSPORT; HYDROXYQUINOLINES; KINETICS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN MULTIMERIZATION; QUINONE REDUCTASES; QUINONES; STAPHYLOCOCCUS AUREUS;

EID: 84943456511     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.13120     Document Type: Article

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