Pharmacogenetics of abacavir hypersensitivity: A systematic review and meta-analysis of the association with HLA-B∗57:01

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 4, 2015, Pages 1092-1094.e3

  Sousa Pinto, Bernardo ^a   Pinto Ramos, João ^a   Correia, Cláudia ^a   Gonçalves Costa, Gustavo ^a   Gomes, Lídia ^a   Gil Mata, Sara ^a   Araújo, Luís ^a   Delgado, Luís ^a  

^a University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; HLA B57 ANTIGEN; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; HLA B ANTIGEN; HLA-B*57:01 ANTIGEN;

BLACK PERSON; CAUCASIAN; DRUG HYPERSENSITIVITY; ETHNICITY; GENETIC RISK; HISPANIC; HLA SYSTEM; HUMAN; LETTER; META ANALYSIS; PATCH TEST; PHARMACOGENETICS; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; FEMALE; GENETICS; IMMUNOLOGY; MALE;

DIDEOXYNUCLEOSIDES; DRUG HYPERSENSITIVITY; FEMALE; HLA-B ANTIGENS; HUMANS; MALE; PHARMACOGENETICS;

EID: 84943455193     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.03.019     Document Type: Article

References (17)

1. M.A. Martin, and D.L. Kroetz Abacavir pharmacogenetics-from initial reports to standard of care Pharmacotherapy 33 2013 765 775
2. E.J. Phillips, W.H. Chung, M. Mockenhaupt, J.C. Roujeau, and S.A. Mallal Drug hypersensitivity: pharmacogenetics and clinical syndromes J Allergy Clin Immunol 127 2011 S60 S66
3. S. Mallal, E. Phillips, G. Carosi, J.M. Molina, C. Workman, J. Tomazic, and et al. HLA-B∗5701 screening for hypersensitivity to abacavir N Engl J Med 358 2008 568 579
4. M. Saag, R. Balu, E. Phillips, P. Brachman, C. Martorell, W. Burman, and et al. High sensitivity of human leukocyte antigen-b∗5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients Clin Infect Dis 46 2008 1111 1118
5. S. Mallal, D. Nolan, C. Witt, G. Masel, A.M. Martin, C. Moore, and et al. Association between presence of HLA-B∗5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir Lancet 359 2002 727 732
6. S. Hetherington, A.R. Hughes, M. Mosteller, D. Shortino, K.L. Baker, W. Spreen, and et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir Lancet 359 2002 1121 1122
7. D.A. Hughes, F.J. Vilar, C.C. Ward, A. Alfirevic, B.K. Park, and M. Pirmohamed Cost-effectiveness analysis of HLA B∗5701 genotyping in preventing abacavir hypersensitivity Pharmacogenetics 14 2004 335 342
8. A.M. Martin, D. Nolan, S. Gaudieri, C.A. Almeida, R. Nolan, I. James, and et al. Predisposition to abacavir hypersensitivity conferred by HLA-B∗5701 and a haplotypic Hsp70-Hom variant Proc Natl Acad Sci U S A 101 2004 4180 4185
9. E.J. Phillips, G.A. Wong, R. Kaul, K. Shahabi, D.A. Nolan, S.R. Knowles, and et al. Clinical and immunogenetic correlates of abacavir hypersensitivity AIDS 19 2005 979 981
10. J. Stekler, J. Maenza, C. Stevens, S. Holte, U. Malhotra, M.J. McElrath, and et al. Abacavir hypersensitivity reaction in primary HIV infection AIDS 20 2006 1269 1274
11. S. Rodriguez-Novoa, P. Garcia-Gasco, F. Blanco, G. Gonzalez-Pardo, C. Castellares, V. Moreno, and et al. Value of the HLA-B∗5701 allele to predict abacavir hypersensitivity in Spaniards AIDS Res Hum Retroviruses 23 2007 1374 1376
12. S. Colombo, A. Rauch, M. Rotger, J. Fellay, R. Martinez, C. Fux, and et al. The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir J Infect Dis 198 2008 864 867
13. A. Rauch, D. Nolan, C. Thurnheer, C.A. Fux, M. Cavassini, J.P. Chave, and et al. Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study Antivir Ther 13 2008 1019 1028
14. P. Munderi, W.B. Snowden, A.S. Walker, C. Kityo, M. Mosteller, G. Kabuye, and et al. Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DART Trop Med Int Health 16 2011 200 204
15. GlaxoSmithKline (GSK) Clinical Study Register [Internet]: Brentford (United Kingdom). 2007. Identifiers CNA30027, CNA30032, CNA30021, CNA30024, EPV40001. Final report from the analysis of candidate gene markers and genome-wide single nucleotide polymorphisms (SNPs) from two retrospective, case-control studies and three controlled clinical studies to investigate genetic polymorphisms in HIV infected subjects who developed hypersensitivity following treatment with abacavir (study RJ2006/00002/00). Result summary; updated August 2, 2007; webpage updated September 28, 2008. Available at: http://www.gsk-clinicalstudyregister.com/study/CNA30027,%20CNA30032,%20CNA30021,%20CNA30024,%20EPV40001#rs. Accessed April 27, 2013.
16. GRADE approach description and methodology Higgins J.P.T., and S. Green Cochrane handbook for systematic reviews of interventions (Version 5.1.0) (updated March 2011) 2011 The Cochrane Collaboration Available at: http://www.cochrane-handbook.org Accessed December 16, 2013
17. E.J. Phillips, J.R. Sullivan, S.R. Knowles, and N.H. Shear First description of abacavir hypersensitivity patch testing: utility of patch testing in patients with hypersensitivity syndromes associated with abacavir AIDS 16 2002 2223 2225