Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 4, 2015, Pages 923-931.e3

  Xiao, Chang ^a   Biagini Myers, Jocelyn M ^a   Ji, Hong ^a   Metz, Kelly ^a   Martin, Lisa J ^a   Lindsey, Mark ^a   He, Hua ^a   Powers, Racheal ^a   Ulm, Ashley ^a   Ruff, Brandy ^a   Ericksen, Mark B ^a   Somineni, Hari K ^a   Simmons, Jeffrey ^a   Strait, Richard T ^a   Kercsmar, Carolyn M ^a   Khurana Hershey, Gurjit K ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

biomarker; Childhood asthma; phenotype; treatment response; vanin 1

Indexed keywords

BECLOMETASONE DIPROPIONATE; BISULFITE; BUDESONIDE; BUDESONIDE PLUS FORMOTEROL; CORTICOSTEROID; DEXAMETHASONE; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL XINAFOATE; FORMOTEROL FUMARATE PLUS MOMETASONE FUROATE; MESSENGER RNA; MOMETASONE FUROATE; PREDNISONE; SALBUTAMOL; AMIDASE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PANTETHEINASE; PHARMACOLOGICAL BIOMARKER;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CHILD; CHILD HOSPITALIZATION; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE EXACERBATION; EMERGENCY PATIENT; EMERGENCY WARD; EPITHELIUM CELL; EXPERIMENTAL ASTHMA; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC CORRELATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MOUSE; NASAL EPITHELIAL CELL; NONHUMAN; NOSE MUCOSA; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROSPECTIVE STUDY; PYROSEQUENCING; SYSTEMIC THERAPY; TREATMENT OUTCOME; TREATMENT RESPONSE; VANIN 1 GENE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; DISEASE COURSE; DNA METHYLATION; EMERGENCY HEALTH SERVICE; GENE EXPRESSION REGULATION; GENETICS; HOSPITALIZATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ADRENAL CORTEX HORMONES; AMIDOHYDROLASES; ANIMALS; ASTHMA; BIOMARKERS, PHARMACOLOGICAL; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE PROGRESSION; DNA METHYLATION; EMERGENCY MEDICAL SERVICES; FEMALE; GENE EXPRESSION REGULATION; GPI-LINKED PROTEINS; HOSPITALIZATION; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MODELS, ANIMAL; NASAL MUCOSA; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84943449524     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.045     Document Type: Article

References (45)

1. L.J. Akinbami, J.E. Moorman, C. Bailey, H.S. Zahran, M. King, C.A. Johnson, and et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010 NCHS Data Brief 94 2012 1 8
2. E.H. Bel Mild asthma N Engl J Med 369 2013 2362
3. B. Fassl, F. Nkoy, B. Stone, R. Srivastava, T. Simon, D. Uchida, and et al. The Joint Commission Children's Asthma Care quality measures and asthma readmissions Pediatrics 130 2012 482 491
4. L. Akinbami Centers for Disease Control and Prevention National Center for Health Statistics The state of childhood asthma, United States, 1980-2005 Adv Data 381 2006 1 24
5. J.M. Drazen, E.K. Silverman, and T.H. Lee Heterogeneity of therapeutic responses in asthma Br Med Bull 56 2000 1054 1070
6. P.G. Woodruff, H.A. Boushey, G.M. Dolganov, C.S. Barker, Y.H. Yang, S. Donnelly, and et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids Proc Natl Acad Sci U S A 104 2007 15858 15863
7. P.G. Woodruff, B. Modrek, D.F. Choy, G. Jia, A.R. Abbas, A. Ellwanger, and et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma Am J Respir Crit Care Med 180 2009 388 395
8. Y. Huang, A.K. Zaas, A. Rao, N. Dobigeon, P.J. Woolf, T. Veldman, and et al. Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza A infection PLoS Genet 7 2011 e1002234
9. K.J. Baines, J.L. Simpson, L.G. Wood, R.J. Scott, N.L. Fibbens, H. Powell, and et al. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes J Allergy Clin Immunol 133 2014 997 1007
10. J.R. Guajardo, K.W. Schleifer, M.O. Daines, R.M. Ruddy, B.J. Aronow, M. Wills-Karp, and et al. Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma J Allergy Clin Immunol 115 2005 243 251
11. A. Poole, C. Urbanek, C. Eng, J. Schageman, S. Jacobson, B.P. O'Connor, and et al. Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease J Allergy Clin Immunol 133 2014 670 678.e12
12. M. Butsch Kovacic, J.M. Biagini Myers, M. Lindsey, T. Patterson, S. Sauter, M.B. Ericksen, and et al. The Greater Cincinnati Pediatric Clinic Repository: a novel framework for childhood asthma and allergy research Pediatr Allergy Immunol Pulmonol 25 2012 104 113
13. A.H. Liu, R.S. Zeiger, C.A. Sorkness, N.K. Ostrom, B.E. Chipps, K. Rosa, and et al. The Childhood Asthma Control Test: retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma J Allergy Clin Immunol 126 2010 267 273.e1
14. Evidence-based care guideline for management of acute exacerbation of asthma in children aged 0 to 18 years. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ). Available at: http://www.guideline.gov/content.aspx?id=24528. Accessed September 16, 2010.
15. S.E. Muething Improving patient outcomes by standardizing care J Pediatr 147 2005 568 570
16. W.E. Gerhardt, P.J. Schoettker, E.F. Donovan, U.R. Kotagal, and S.E. Muething Putting evidence-based clinical practice guidelines into practice: an academic pediatric center's experience Jt Comm J Qual Patient Saf 33 2007 226 235
17. E.B. Brandt, M.B. Kovacic, G.B. Lee, A.M. Gibson, T.H. Acciani, T.D. Le Cras, and et al. Diesel exhaust particle induction of IL-17A contributes to severe asthma J Allergy Clin Immunol 132 2013 1194 1204.e2
18. B.D. Ripley Pattern recognition and neural networks 1996 The Press Syndicate of the University of Cambridge Cambridge (United Kingdom)
19. P.C. Austin An introduction to propensity score methods for reducing the effects of confounding in observational studies Multivariate Behav Res 46 2011 399 424
20. J. Bousquet, E. Mantzouranis, A.A. Cruz, N. Ait-Khaled, C.E. Baena-Cagnani, E.R. Bleecker, and et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma J Allergy Clin Immunol 126 2010 926 938
21. M.C. Bell, and W.W. Busse Severe asthma: an expanding and mounting clinical challenge J Allergy Clin Immunol Pract 1 2013 110 122
22. D. Desai, and C. Brightling Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol 158 2009 10 19
23. J. Corren, R.F. Lemanske, N.A. Hanania, P.E. Korenblat, M.V. Parsey, J.R. Arron, and et al. Lebrikizumab treatment in adults with asthma N Engl J Med 365 2011 1088 1098
24. S. Wenzel, L. Ford, D. Pearlman, S. Spector, L. Sher, F. Skobieranda, and et al. Dupilumab in persistent asthma with elevated eosinophil levels N Engl J Med 368 2013 2455 2466
25. B. Zhang, C. Lo, L. Shen, R. Sood, C. Jones, K. Cusmano-Ozog, and et al. The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP Blood 117 2011 4569 4579
26. F. Sanchez-Munoz, L.M. Amezcua-Guerra, M. Macias-Palacios, R. Marquez-Velasco, and R. Bojalil Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus Lupus 22 2013 333 335
27. T. Gensollen, C. Bourges, P. Rihet, A. Rostan, V. Millet, T. Noguchi, and et al. Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases Inflamm Bowel Dis 19 2013 2315 2325
28. N. Zimmermann, A. Mishra, N.E. King, P.C. Fulkerson, M.P. Doepker, N.M. Nikolaidis, and et al. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways J Immunol 172 2004 1815 1824
29. C.C. Lewis, B. Aronow, J. Hutton, J. Santeliz, K. Dienger, N. Herman, and et al. Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung J Allergy Clin Immunol 123 2009 795 804.e8
30. G. Pitari, F. Malergue, F. Martin, J.M. Philippe, M.T. Massucci, C. Chabret, and et al. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice FEBS Lett 483 2000 149 154
31. C. Berruyer, F.M. Martin, R. Castellano, A. Macone, F. Malergue, S. Garrido-Urbani, and et al. Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress Mol Cell Biol 24 2004 7214 7224
32. C.J. Bossley, L. Fleming, A. Gupta, N. Regamey, J. Frith, T. Oates, and et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines J Allergy Clin Immunol 129 2012 974 982.e13
33. G.C. Hon, R.D. Hawkins, O.L. Caballero, C. Lo, R. Lister, M. Pelizzola, and et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer Genome Res 22 2012 246 258
34. S.B. Baylin DNA methylation and gene silencing in cancer Nat Clin Pract Oncol 2 suppl 1 2005 S4 S11
35. X. Nan, S. Cross, and A. Bird Gene silencing by methyl-CpG-binding proteins Novartis Found Symp 214 1998 6 21 46-50
36. M. Kulis, S. Heath, M. Bibikova, A.C. Queiros, A. Navarro, G. Clot, and et al. Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia Nat Genet 44 2012 1236 1242
37. J.R. Wagner, S. Busche, B. Ge, T. Kwan, T. Pastinen, and M. Blanchette The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts Genome Biol 15 2014 R37
38. S. Hu, J. Wan, Y. Su, Q. Song, Y. Zeng, H.N. Nguyen, and et al. DNA methylation presents distinct binding sites for human transcription factors Elife 2 2013 e00726
39. H. Wang, M.T. Maurano, H. Qu, K.E. Varley, J. Gertz, F. Pauli, and et al. Widespread plasticity in CTCF occupancy linked to DNA methylation Genome Res 22 2012 1680 1688
40. A.C. Bell, A.G. West, and G. Felsenfeld The protein CTCF is required for the enhancer blocking activity of vertebrate insulators Cell 98 1999 387 396
41. A.T. Hark, C.J. Schoenherr, D.J. Katz, R.S. Ingram, J.M. Levorse, and S.M. Tilghman CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus Nature 405 2000 486 489
42. A.C. Bell, and G. Felsenfeld Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene Nature 405 2000 482 485
43. C. Berruyer, L. Pouyet, V. Millet, F.M. Martin, A. LeGoffic, A. Canonici, and et al. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity J Exp Med 203 2006 2817 2827
44. G. Pitari, F. Malergue, F. Martin, J.M. Philippe, M.T. Massucci, C. Chabret, and et al. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice FEBS Lett 483 2000 149 154
45. E.B. Brandt, M.B. Kovacic, G.B. Lee, A.M. Gibson, T.H. Acciani, T.D. Le Cras, and et al. Diesel exhaust particle induction of IL-17A contributes to severe asthma J Allergy Clin Immunol 132 2013 1194 1204.e2