Transmural APD gradient synchronizes repolarization in the human left ventricular wall

Cardiovascular Research

Volumn 108, Issue 1, 2015, Pages 188-196

  Boukens, Bastiaan J ^a   Sulkin, Matthew S ^b   Gloschat, Chris R ^a   Ng, Fu Siong ^c   Vigmond, Edward J ^d   Efimov, Igor R ^a,b,d  

^a George Washington University   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Human; Optical mapping; Repolarization; T wave

Indexed keywords

ACTION POTENTIAL DURATION; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; COMPUTER SIMULATION; DISPERSION; ENDOCARDIUM; EPICARDIUM; FEMALE; HEART LEFT VENTRICLE WALL; HEART PACING; HEART REPOLARIZATION; HUMAN; MALE; MIDDLE AGED; PRIORITY JOURNAL; SCHOOL CHILD; SIMULATION; T WAVE; TISSUE PREPARATION; ACTION POTENTIAL; ELECTROCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION;

ACTION POTENTIALS; ADULT; AGED; CHILD; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; MALE; MIDDLE AGED; VENTRICULAR FUNCTION, LEFT;

EID: 84943420007     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv202     Document Type: Article

References (35)

1. Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Splawski I, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, Wang Q, Zareba W, Keating MT, Towbin JA, Napolitano C, Medina A. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation 2000; 102: 2849-2855
2. Franz MR, Bargheer K, Costard-Jackle A, Miller DC, Lichtlen PR. Human ventricular repolarization and T wave genesis. Prog Cardiovasc Dis 1991; 33: 369-384
3. Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, Kalish PW, Schuessler RB, Moazami N, Efimov IR. Transmural dispersion of repolarization in failing and nonfailing human ventricle. Circ Res 2010; 106: 981-991
4. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M Cell Circ Res 1991; 68: 1729-1741
5. Drouin E, Charpentier F, Gauthier C, Laurent K, Le Marec H. Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: evidence for presence of M cells. J Am Coll Cardiol 1995; 26: 185-192
6. Opthof T, Coronel R, Janse M, Rosen M. A wedge is not a heart. Heart Rhythm 2007; 8: 1116-1119
7. Opthof T, Coronel R, Wilms-Schopman FJG, Plotnikov AN, Shlapakova IN, Danilo P, Rosen MR, Janse MJ. Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion. Heart Rhythm 2007; 4: 341-348
8. Myles RC, Bernus O, Burton FL, Cobbe SM, Smith GL. Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. Am J Physiol Heart Circ Physiol 2010; 299: H1812-H1822
9. Janse MJ, Coronel R, Opthof T, Sosunov EA, Anyukhovsky EP, Rosen MR. Repolarization gradients in the intact heart: transmural or apico-basal? Prog Biophys Mol Biol 2012; 109: 6-15
10. Meijborg VM, Conrath CE, Opthof T, Belterman CN, de Bakker JM, Coronel R. Electrocardiographic T wave and its relation with ventricular repolarization along major anatomical axes. Circ Arrhythm Electrophysiol 2014; 7: 524-531
11. Defauw A, Kazbanov IV, Dierckx H, Dawyndt P, Panfilov AV. Action potential duration heterogeneity of cardiac tissue can be evaluated from cell properties using Gaussian Greens function approach. PLoS ONE 2013; 8: e79607
12. Walton RD, Benson AP, Hardy ME, White E, Bernus O. Electrophysiological and structural determinants of electrotonic modulation of repolarization by the activation sequence. Front Physiol 2013; 4: 281
13. World Medical Association Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997; 277: 925-926
14. Di Diego JM, Sicouri S, Myles RC, Burton FL, Smith GL, Antzelevitch C. Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. J Mol Cell Cardiol 2013; 54: 53-64
15. ten Tusscher KH, Panfilov AV. Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol 2006; 291: H1088-H1100
16. Laughner JI, Ng FS, Sulkin MS, Arthur RM, Efimov IR. Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes. Am J Physiol Heart Circ Physiol 2012; 303: H753-H765
17. Potse M, Vinet A, Opthof T, Coronel R. Validation of a simple model for the morphology of the T wave in unipolar electrograms. Am J Physiol Heart Circ Physiol 2009; 297: H792-H801
18. Haralick RM, Shanmugam K, Itshak D. Textural features for image classification. IEEE Trans Syst Man Cybern 1973; SMC-6: 11
19. Lepeschkin E, Surawicz B. The measurement of the Q-T interval of the electrocardiogram. Circulation 1952; 6: 378-388
20. Durrer D, Van Dam RT, Freud GE, Janse MJ, Meijler FL, Arzbaecher RC. Total excitation of the isolated human heart. Circulation 1970; 41: 899-912
21. Franz MR, Bargheer K, Rafflenbeul W, Haverich A, Lichtlen PR. Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T wave. Circulation 1987; 75: 379-386
22. Cowan JC, Hilton CJ, Griffiths CJ, Tansuphaswadikul S, Bourke JP, Murray A, Campbell RW. Sequence of epicardial repolarisation and configuration of the T wave. Br Heart J 1988; 60: 424-433
23. Gima K, Rudy Y. Ionic current basis of electrocardiographic waveforms: a model study. Circ Res 2002; 90: 889-896
24. Plonsley RB, Roger C. Bioelectricity: A Quantitative Approach. New York, NY: Plenum Press, p149-163
25. Ng FS, Holzem KM, Koppel AC, Janks D, Gordon F, Wit AL, Peters NS, Efimov IR. Adverse remodeling of the electrophysiological response to ischemia-reperfusion in human heart failure is associated with remodeling of metabolic gene expression. Circ Arrhythm Electrophysiol 2014; 7: 875-882
26. Glukhov AV, Fedorov VV, Kalish PW, Ravikumar VK, Lou Q, Janks D, Schuessler RB, Moazami N, Efimov IR. Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy. Circulation 2012; 125: 1835-1847
27. Taggart P, Sutton PM, Opthof T, Coronel R, Trimlett R, Pugsley W, Kallis P. Transmural repolarisation in the left ventricle in humans during normoxia and ischaemia. Cardiovasc Res 2001; 50: 454-462
28. Lou Q, Fedorov VV, Glukhov AV, Moazami N, Fast VG, Efimov IR. Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure. Circulation 2011; 123: 1881-1890
29. Walton RD, Martinez ME, Bishop MJ, Hocini M, Haissaguerre M, Plank G, Bernus O, Vigmond EJ. Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity. Cardiovasc Res 2014; 103: 629-640
30. Zicha S, Xiao L, Stafford S, Cha TJ, Han W, Varro A, Nattel S. Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts. J Physiol 2004; 561: 735-748
31. Nabauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 1996; 93: 168-177
32. Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, Demolombe S. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 2007; 582: 675-693
33. Rosenbaum MB, Blanco HH, Elizari MV, Lazzari JO, Davidenko JM. Electrotonic modulation of the T wave and cardiac memory. Am J Cardiol 1982; 50: 213-222
34. Boukens BJ, Christoffels VM, Coronel R, Moorman AF. Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-Threatening ventricular arrhythmias. Circ Res 2009; 104: 19-31
35. Joyner RW, Picone J, Veenstra R, Rawling D. Propagation through electrically coupled cells. Effects of regional changes in membrane properties. Circ Res 1983; 53: 526-534