Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 40, 2015, Pages 12486-12491

  Clark, Andrew J ^a   Davis, Mark E ^a  

^a California Institute of Technology   (United States)

Author keywords

Blood brain barrier; In vivo; Systemic administration; Therapeutic delivery; Transcytosis

Indexed keywords

ANTIBODY; GOLD NANOPARTICLE; TRANSFERRIN; TRANSFERRIN RECEPTOR; ACID; GOLD; METAL NANOPARTICLE; PROTEIN BINDING;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ARTICLE; BLOOD BRAIN BARRIER; CONFORMATIONAL TRANSITION; FEMALE; HEMISPHERE; HYDROLYSIS KINETICS; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TRANSCYTOSIS; ANIMAL; BAGG ALBINO MOUSE; BRAIN; CELL LINE; CHEMISTRY; CYTOLOGY; ENDOTHELIUM; HUMAN; IMMUNOLOGY; METABOLISM; TUMOR CELL LINE;

ACIDS; ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; CELL LINE, TUMOR; ENDOTHELIUM; FEMALE; GOLD; HUMANS; METAL NANOPARTICLES; MICE, INBRED BALB C; PROTEIN BINDING; RECEPTORS, TRANSFERRIN; TRANSCYTOSIS; TRANSFERRIN;

EID: 84943410720     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1517048112     Document Type: Article

References (25)

1. Pardridge WM (2005) The blood-brain barrier: Bottleneck in brain drug development. NeuroRx 2(1):3-14.
2. Chen Y, Liu L. (2012) Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev 64(7):640-665.
3. Jones AR, Shusta E.V. (2007) Blood-brain barrier transport of therapeutics via receptormediation. Pharm Res 24(9):1759-1771.
4. Kinoshita M, McDannold N, Jolesz F.A., Hynynen K. (2006) Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci USA 103(31):11719-11723.
5. Uchida Y, et al (2011) Quantitative targeted absolute proteomics of human bloodbrain barrier transporters and receptors. J Neurochem 117(2):333-345.
6. Lajoie JM, Shusta E.V. (2015) Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annu Rev Pharmacol Toxicol 55(1):613-631.
7. Widera A, Norouziyan F, Shen W.C. (2003) Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery. Adv Drug Deliv Rev 55(11):1439-1466.
8. Friden PM, et al (1991) Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc Natl Acad Sci USA 88(11):4771-4775.
9. Yu YJ, et al (2011) Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med 3(84):84ra44.
10. Bien-Ly N., et al (2014) Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. J Exp Med 211(2):233-244.
11. Niewoehner J, et al (2014) Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 81(1):49-60.
12. Wiley DT, Webster P, Gale A., Davis M.E. (2013) Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor. Proc Natl Acad Sci USA 110(21):8662-8667.
13. Mellman I (1996) Endocytosis and molecular sorting. Annu Rev Cell Dev Biol 12: 575-625.
14. Mellman I, Fuchs R, Helenius A. (1986) Acidification of the endocytic and exocytic pathways. Annu Rev Biochem 55:663-700.
15. Sade H, et al (2014) A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding. PLoS One 9(4):e96340.
16. Binauld S, Stenzel M.H. (2013) Acid-degradable polymers for drug delivery: A decade of innovation. Chem Commun (Camb) 49(21):2082-2102.
17. Nance EA, et al (2012) A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med 4(149):149ra119.
18. Cao X, Ye Y, Liu S. (2011) Gold nanoparticle-based signal amplification for biosensing. Anal Biochem 417(1):1-16.
19. Brown RC, Morris AP, O'Neil RG (2007) Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells. Brain Res 1130(1):17-30.
20. Cho EC, Zhang Q, Xia Y. (2011) The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat Nanotechnol 6(6):385-391.
21. Fishman JB, Rubin JB, Handrahan J.V., Connor JR, Fine R.E. (1987) Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res 18(2):299-304.
22. Leriche G, Chisholm L, Wagner A. (2012) Cleavable linkers in chemical biology. Bioorg Med Chem 20(2):571-582.
23. Dautry-Varsat A., Ciechanover A, Lodish H.F. (1983) pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci USA 80(8):2258-2262.
24. Luck AN, Mason A.B. (2013) Structure and dynamics of drug carriers and their interaction with cellular receptors: Focus on serum transferrin. Adv Drug Deliv Rev 65(8):1012-1019.
25. Committee on Care and Use of Laboratory Animals (1996) Guide for the Care and Use of Laboratory Animals (Natl Inst Health, Bethesda), DHHS Publ No (NIH) 85-23.