The loss of LRPPRC function induces the mitochondrial unfolded protein response

Aging

Volumn 7, Issue 9, 2015, Pages 701-717

  Köhler, Fabian ^a   Müller Rischart, Anne Kathrin ^a   Conradt, Barbara ^a   Rolland, Stéphane Guy ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

LRPPRC; Mitochondrial hyperfusion; Mitochondrial stress response; mma 1; UPRmt

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAENORHABDITIS ELEGANS PROTEIN; LRPPRC PROTEIN, C ELEGANS; LRPPRC PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MMA-1 PROTEIN, C ELEGANS; SMALL INTERFERING RNA; TUMOR PROTEIN;

AGING; ANIMAL; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; UNFOLDED PROTEIN RESPONSE;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEOPLASM PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 84943399501     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100812     Document Type: Article

References (33)

1. Blackstone NW. The impact of mitochondrial endosymbiosis on the evolution of calcium signaling. Cell calcium. 2015; 57:133-139.
2. Saraste M. Oxidative phosphorylation at the fin de siecle. Science. 1999; 283:1488-1493.
3. Wang C, and Youle RJ. The role of mitochondria in apoptosis. Annual review of genetics. 2009; 43:95-118.
4. Larsson NG. Somatic mitochondrial DNA mutations in mammalian aging. Annual review of biochemistry. 2010; 79:683-706.
5. Niforou K, Cheimonidou C, and Trougakos IP. Molecular chaperones and proteostasis regulation during redox imbalance. Redox biology. 2014; 2:323-332.
6. Jensen MB, and Jasper H. Mitochondrial proteostasis in the control of aging and longevity. Cell metabolism. 2014; 20:214-225.
7. Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, and Auwerx J. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature. 2013; 497:451-457.
8. Narendra D, Walker JE, and Youle R. Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harbor perspectives in biology. 2012; 4: a011338.
9. Pellegrino MW, Nargund AM, and Haynes CM. Signaling the mitochondrial unfolded protein response. Biochimica et biophysica acta. 2013; 1833:410-416.
10. Gomes LC, Di Benedetto G, and Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nature cell biology. 2011; 13:589-598.
11. Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF, and Conradt B. Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110:E2967-2976.
12. Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC et al. SLP-2 is required for stress-induced mitochondrial hyperfusion. The EMBO journal. 2009; 28:1589-1600.
13. Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, Mitchell GA, Morin C, Mann M, et al. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100:605-610.
14. Ruzzenente B, Metodiev MD, Wredenberg A, Bratic A, Park CB, Camara Y, Milenkovic D, Zickermann V, Wibom R, Hultenby K, Erdjument-Bromage H, Tempst P, Brandt U, et al. LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. The EMBO journal. 2012; 31:443-456.
15. Sasarman F, Brunel-Guitton C, Antonicka H, Wai T, Shoubridge EA, and Consortium L. LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria. Molecular biology of the cell. 2010; 21:1315-1323.
16. Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landazuri MO, and Enriquez JA. NDUFA4 is a subunit of complex IV of the mammalian electron transport chain. Cell metabolism. 2012; 16:378-386.
17. Lemire B. Mitochondrial genetics. WormBook: the online review of C. elegans biology. 2005; 1-10
18. Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, and Ron D. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Journal of cell science. 2004; 117:4055-4066.
19. Timmons L, Court DL, and Fire A. Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene. 2001; 263:103-112.
20. Hadwiger G, Dour S, Arur S, Fox P, and Nonet ML. A monoclonal antibody toolkit for C. elegans. PloS one. 2010; 5:e10161.
21. Haynes CM, Yang Y, Blais SP, Neubert TA, and Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Molecular cell. 2010; 37:529-540.
22. Nargund, AM, Pellegrino MW, Fiorese CJ, Baker BM, and Haynes CM. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science. 2012; 337:587-590.
23. Friedman JR, and Nunnari J. Mitochondrial form and function. Nature. 2014; 505:335-343.
24. Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, and Haynes CM. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014; 516:414-417.
25. Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nature communications. 2014; 5:3483.
26. Regmi SG, Rolland SG, Conradt B. Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan. Aging. 2014; 6:118-130.
27. Iqbal S, Ostojic O, Singh K, Joseph AM, Hood DA. Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse. Muscle&nerve. 2013; 48:963-970.
28. Sgarbi G, Matarrese P, Pinti M, Lanzarini C, Ascione B, Gibellini L, Dika E, Patrizi A, Tommasino C, Capri M, Cossarizza A, Baracca A, Lenaz G et al. Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians. Aging. 2014; 6:296-310.
29. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974; 77:71-94.
30. Riddle DL, Blumenthal T, Meyer BJ, and Priess JR. Introduction to C. elegans. in C. elegans II (Riddle, D. L., Blumenthal, T., Meyer, B. J., and Priess, J. R. eds.), 2nd Ed., Cold Spring Harbor (NY). 1997.
31. Kamath RS, and Ahringer J. Genome-wide RNAi screening in Caenorhabditis elegans. Methods. 2003; 30:313-321.
32. Rolland SG, Lu Y, David CN, and Conradt B. The BCL-2-like protein CED-9 of C. elegans promotes FZO-1/Mfn1,2-and EAT-3/Opa1-dependent mitochondrial fusion. The Journal of cell biology. 2009; 186:525-540.
33. Yokoyama K, Fukumoto K, Murakami T, Harada S, Hosono R, Wadhwa R, Mitsui Y, and Ohkuma S. Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS letters. 2002; 516:53-57.