메뉴 건너뛰기




Volumn 148, Issue 4, 2015, Pages 1063-1072

Advances in molecular biology of lung disease aiming for precision therapy in non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ALECTINIB; ANAPLASTIC LYMPHOMA KINASE; CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; PROTEIN TYROSINE KINASE INHIBITOR; GENETIC MARKER; TUMOR MARKER;

EID: 84943391839     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.14-2663     Document Type: Article
Times cited : (16)

References (74)
  • 1
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC) [abstract]
    • Kris MG, Johnson BE, Kwiatkowski DJ, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC) [abstract]. J Clin Oncol. 2011; 29 (suppl):CRA7506.
    • (2011) J Clin Oncol. , vol.29 , pp. CRA7506
    • Kris, M.G.1    Johnson, B.E.2    Kwiatkowski, D.J.3
  • 2
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers [published correction in Nature. 2012;491(7426): 288]
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers [published correction in Nature. 2012;491(7426):288]. Nature. 2012; 489 (7417): 519-525.
    • (2012) Nature. , vol.489 , Issue.7417 , pp. 519-525
  • 3
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma . Clin Cancer Res. 2008; 14 (18): 5731-5734.
    • (2008) Clin Cancer Res. , vol.14 , Issue.18 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 4
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004; 350 (21): 2129-2139.
    • (2004) N Engl J Med. , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 5
    • 78149470440 scopus 로고    scopus 로고
    • Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers
    • Lee SY, Kim MJ, Jin G, et al. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. J Thorac Oncol. 2010; 5 (11): 1734-1740.
    • (2010) J Thorac Oncol. , vol.5 , Issue.11 , pp. 1734-1740
    • Lee, S.Y.1    Kim, M.J.2    Jin, G.3
  • 6
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009; 15 (16): 5216-5223.
    • (2009) Clin Cancer Res. , vol.15 , Issue.16 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 7
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007; 104 (52): 20932-20937.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.52 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 8
    • 33751084640 scopus 로고    scopus 로고
    • PIK3CA mutation status in Japanese lung cancer patients
    • Kawano O, Sasaki H, Endo K, et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer. 2006; 54 (2): 209-215.
    • (2006) Lung Cancer. , vol.54 , Issue.2 , pp. 209-215
    • Kawano, O.1    Sasaki, H.2    Endo, K.3
  • 9
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012; 18 (3): 375-377.
    • (2012) Nat Med. , vol.18 , Issue.3 , pp. 375-377
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3
  • 10
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012; 30 (8): 863-870.
    • (2012) J Clin Oncol. , vol.30 , Issue.8 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 11
    • 84883022821 scopus 로고    scopus 로고
    • Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer
    • Cardarella S, Ogino A, Nishino M, et al. Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin Cancer Res. 2013; 19 (16): 4532-4540.
    • (2013) Clin Cancer Res. , vol.19 , Issue.16 , pp. 4532-4540
    • Cardarella, S.1    Ogino, A.2    Nishino, M.3
  • 12
    • 79958112619 scopus 로고    scopus 로고
    • Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
    • Dutt A, Ramos AH, Hammerman PS, et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One. 2011; 6 (6): e20351.
    • (2011) PLoS One. , vol.6 , Issue.6 , pp. e20351
    • Dutt, A.1    Ramos, A.H.2    Hammerman, P.S.3
  • 13
    • 84877679631 scopus 로고    scopus 로고
    • Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines
    • Socinski MA, Evans T, Gettinger S, et al. Treatment of stage IV non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines. Chest. 2013 ;143(5-suppl): e341S-e368S.
    • (2013) Chest. , vol.143 , Issue.5 , pp. e341S-e368S
    • Socinski, M.A.1    Evans, T.2    Gettinger, S.3
  • 14
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009; 361 (10): 947-957.
    • (2009) N Engl J Med. , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 15
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica
    • Rosell R, Carcereny E, Gervais R, et al; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012; 13 (3): 239-246.
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 16
    • 84862819699 scopus 로고    scopus 로고
    • Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
    • Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012; 13 (5): 539-548.
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 539-548
    • Yang, J.C.1    Shih, J.Y.2    Su, W.C.3
  • 17
    • 84866655838 scopus 로고    scopus 로고
    • LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations [abstract]
    • Yang JC-H, Schuler MH, Yamamoto N, et al. LUX-Lung 3: a randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations [abstract]. J Clin Oncol. 2012;30(suppl):LBA7500.
    • (2012) J Clin Oncol. , vol.30 , pp. LBA7500
    • Jc-H, Y.1    Schuler, M.H.2    Yamamoto, N.3
  • 18
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010; 363(18): 1693-1703.
    • (2010) N Engl J Med. , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 19
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005; 97 (5): 339-346.
    • (2005) J Natl Cancer Inst. , vol.97 , Issue.5 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 20
    • 33745307617 scopus 로고    scopus 로고
    • Ras PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006; 441 (7092): 424-430.
    • (2006) Nature. , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 21
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science. 2004; 305 (5687): 1163-1167.
    • (2004) Science. , vol.305 , Issue.5687 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 22
    • 5644293135 scopus 로고    scopus 로고
    • Gefitinib induces apoptosis in the EGFRL858R non-smallcell lung cancer cell line H3255
    • Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Jänne PA. Gefitinib induces apoptosis in the EGFRL858R non-smallcell lung cancer cell line H3255. Cancer Res. 2004; 64 (20): 7241-7244.
    • (2004) Cancer Res. , vol.64 , Issue.20 , pp. 7241-7244
    • Tracy, S.1    Mukohara, T.2    Hansen, M.3    Meyerson, M.4    Johnson, B.E.5    Jänne, P.A.6
  • 23
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005; 366 (9496): 1527-1537.
    • (2005) Lancet. , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 24
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013; 31 (27): 3327-3334.
    • (2013) J Clin Oncol. , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 25
    • 84863892117 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
    • Jänne PA, Wang X, Socinski MA, et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol. 2012; 30 (17): 2063-2069.
    • (2012) J Clin Oncol. , vol.30 , Issue.17 , pp. 2063-2069
    • Jänne, P.A.1    Wang, X.2    Socinski, M.A.3
  • 26
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • West Japan Oncology Group
    • Mitsudomi T, Morita S, Yatabe Y, et al; West Japan Oncology Group. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010; 11 (2): 121-128.
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 27
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • North-East Japan Study Group
    • Maemondo M, Inoue A, Kobayashi K, et al; North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010; 362 (25): 2380-2388.
    • (2010) N Engl J Med. , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 28
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutationpositive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutationpositive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011; 12 (8): 735-742.
    • (2011) Lancet Oncol. , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 29
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial
    • Wu Y-L, Zhou C, Hu CP, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014; 15 (2): 213-222.
    • (2014) Lancet Oncol. , vol.15 , Issue.2 , pp. 213-222
    • Wu, Y.-L.1    Zhou, C.2    Hu, C.P.3
  • 30
    • 84964698676 scopus 로고    scopus 로고
    • Management and future directions in non-small cell lung cancer with known activating mutations
    • Gerber D, Gandhi L, Costa DB. Management and future directions in non-small cell lung cancer with known activating mutations. Am Soc Clin Oncol Educ Book. 2014:e353-e365.
    • (2014) Am Soc Clin Oncol Educ Book. , pp. e353-e365
    • Gerber, D.1    Gandhi, L.2    Costa, D.B.3
  • 31
    • 84883055532 scopus 로고    scopus 로고
    • Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): A randomised controlled trial
    • TAILOR Trialists
    • Garassino MC, Martelli O, Broggini M, et al; TAILOR Trialists. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol. 2013; 14 (10): 981-988.
    • (2013) Lancet Oncol. , vol.14 , Issue.10 , pp. 981-988
    • Garassino, M.C.1    Martelli, O.2    Broggini, M.3
  • 32
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • National Cancer Institute of Canada Clinical Trials Group
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005; 353 (2): 123-132.
    • (2005) N Engl J Med. , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 33
    • 84855310079 scopus 로고    scopus 로고
    • EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
    • Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol. 2012; 13 (1): e23-e31.
    • (2012) Lancet Oncol. , vol.13 , Issue.1 , pp. e23-e31
    • Yasuda, H.1    Kobayashi, S.2    Costa, D.B.3
  • 34
    • 75349110926 scopus 로고    scopus 로고
    • Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
    • Eck MJ, Yun CH. Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta. 2010 ;1804(3):559-566.
    • (2010) Biochim Biophys Acta. , vol.1804 , Issue.3 , pp. 559-566
    • Eck, M.J.1    Yun, C.H.2
  • 35
    • 74549120147 scopus 로고    scopus 로고
    • Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: A preliminary report
    • Girard N, Lou E, Azzoli CG, et al. Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report. Clin Cancer Res. 2010; 16 (2): 755-763.
    • (2010) Clin Cancer Res. , vol.16 , Issue.2 , pp. 755-763
    • Girard, N.1    Lou, E.2    Azzoli, C.G.3
  • 36
    • 28444455958 scopus 로고    scopus 로고
    • Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
    • Bell DW, Gore I, Okimoto RA, et al. Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nat Genet. 2005; 37 (12): 1315-1316.
    • (2005) Nat Genet. , vol.37 , Issue.12 , pp. 1315-1316
    • Bell, D.W.1    Gore, I.2    Okimoto, R.A.3
  • 37
    • 79960856289 scopus 로고    scopus 로고
    • Drug-induced effects on erlotinib metabolism
    • Mir O, Blanchet B, Goldwasser F. Drug-induced effects on erlotinib metabolism. N Engl J Med. 2011; 365 (4): 379-380.
    • (2011) N Engl J Med. , vol.365 , Issue.4 , pp. 379-380
    • Mir, O.1    Blanchet, B.2    Goldwasser, F.3
  • 38
    • 33646238486 scopus 로고    scopus 로고
    • Effects of smoking on the pharmacokinetics of erlotinib
    • Hamilton M, Wolf JL, Rusk J, et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006; 12 (7): 2166-2171.
    • (2006) Clin Cancer Res. , vol.12 , Issue.7 , pp. 2166-2171
    • Hamilton, M.1    Wolf, J.L.2    Rusk, J.3
  • 39
    • 84857002194 scopus 로고    scopus 로고
    • BIM expression in treatmentnaive cancers predicts responsiveness to kinase inhibitors
    • Faber AC, Corcoran RB, Ebi H, et al. BIM expression in treatmentnaive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011; 1 (4): 352-365.
    • (2011) Cancer Discov. , vol.1 , Issue.4 , pp. 352-365
    • Faber, A.C.1    Corcoran, R.B.2    Ebi, H.3
  • 40
    • 84862777672 scopus 로고    scopus 로고
    • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
    • Ng KP, Hillmer AM, Chuah CT, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med. 2012; 18(4): 521-528.
    • (2012) Nat Med. , vol.18 , Issue.4 , pp. 521-528
    • Ng, K.P.1    Hillmer, A.M.2    Chuah, C.T.3
  • 41
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011; 3 (75): 75ra26.
    • (2011) Sci Transl Med. , vol.3 , Issue.75 , pp. 75ra26
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 42
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun CH, Mengwasser KE, Toms AV, et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A. 2008; 105 (6): 2070-2075.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.6 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3
  • 43
    • 35648949422 scopus 로고    scopus 로고
    • BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
    • Costa DB, Halmos B, Kumar A, et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med. 2007; 4 (10): 1669-1679.
    • (2007) PLoS Med. , vol.4 , Issue.10 , pp. 1669-1679
    • Costa, D.B.1    Halmos, B.2    Kumar, A.3
  • 44
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007; 316 (5827): 1039-1043.
    • (2007) Science. , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 45
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 2008; 68 (22): 9479-9487.
    • (2008) Cancer Res. , vol.68 , Issue.22 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3
  • 46
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi K, Sequist LV, Arcila ME, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A. 2012; 109 (31): E2127-E2133.
    • (2012) Proc Natl Acad Sci U S A. , vol.109 , Issue.31 , pp. E2127-E2133
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 47
    • 84868010326 scopus 로고    scopus 로고
    • Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors
    • Ercan D, Xu C, Yanagita M, et al. Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2012; 2 (10): 934-947.
    • (2012) Cancer Discov. , vol.2 , Issue.10 , pp. 934-947
    • Ercan, D.1    Xu, C.2    Yanagita, M.3
  • 48
    • 84864621910 scopus 로고    scopus 로고
    • Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers
    • Cheung HW, Du J, Boehm JS, et al. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov. 2011; 1 (7): 608-625.
    • (2011) Cancer Discov. , vol.1 , Issue.7 , pp. 608-625
    • Cheung, H.W.1    Du, J.2    Boehm, J.S.3
  • 49
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012; 13 (5): 528-538.
    • (2012) Lancet Oncol. , vol.13 , Issue.5 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 50
    • 84904657511 scopus 로고    scopus 로고
    • First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations of EGFR (activating and T790M) [abstract]
    • Sequist LV, Soria J-C, Gadgeel SM, et al. First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations of EGFR (activating and T790M) [abstract]. J Clin Oncol. 2014;32(suppl 5):8010.
    • (2014) J Clin Oncol. , vol.32 , pp. 8010
    • Sequist, L.V.1    Soria, J.-C.2    Gadgeel, S.M.3
  • 51
    • 84904624695 scopus 로고    scopus 로고
    • Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) [abstract]
    • Janne PA, Ramalingam SS, Yang JC-H, et al. Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2014;32(suppl 5):8009.
    • (2014) J Clin Oncol. , vol.32 , pp. 8009
    • Janne, P.A.1    Ramalingam, S.S.2    Jc-H, Y.3
  • 52
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007; 448 (7153): 561-566.
    • (2007) Nature. , vol.448 , Issue.7153 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 53
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009; 27 (26): 4247-4253.
    • (2009) J Clin Oncol. , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 54
    • 78049426513 scopus 로고    scopus 로고
    • EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • ALK Lung Cancer Study Group
    • Choi YL, Soda M, Yamashita Y, et al; ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010; 363 (18): 1734-1739.
    • (2010) N Engl J Med. , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 55
    • 79954592031 scopus 로고    scopus 로고
    • Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
    • Takezawa K, Okamoto I, Nishio K, Jänne PA, Nakagawa K. Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. Clin Cancer Res. 2011; 17 (8): 2140-2148.
    • (2011) Clin Cancer Res. , vol.17 , Issue.8 , pp. 2140-2148
    • Takezawa, K.1    Okamoto, I.2    Nishio, K.3    Jänne, P.A.4    Nakagawa, K.5
  • 56
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013; 368 (25): 2385-2394.
    • (2013) N Engl J Med. , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 57
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
    • Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012; 4 (120): 120ra17.
    • (2012) Sci Transl Med. , vol.4 , Issue.120 , pp. 120ra17
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 58
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012 ;18(5):1472-1482.
    • (2012) Clin Cancer Res. , vol.18 , Issue.5 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 59
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011; 71 (18): 6051-6060.
    • (2011) Cancer Res. , vol.71 , Issue.18 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3
  • 60
    • 81355124049 scopus 로고    scopus 로고
    • Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen
    • Zhang S, Wang F, Keats J, et al. Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011; 78 (6): 999-1005.
    • (2011) Chem Biol Drug Des. , vol.78 , Issue.6 , pp. 999-1005
    • Zhang, S.1    Wang, F.2    Keats, J.3
  • 61
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • Shaw AT, Kim D-W, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014; 370 (13): 1189-1197.
    • (2014) N Engl J Med. , vol.370 , Issue.13 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.-W.2    Mehra, R.3
  • 62
    • 84877679409 scopus 로고    scopus 로고
    • Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
    • Sang J, Acquaviva J, Friedland JC, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov. 2013; 3 (4): 430-443.
    • (2013) Cancer Discov. , vol.3 , Issue.4 , pp. 430-443
    • Sang, J.1    Acquaviva, J.2    Friedland, J.C.3
  • 63
    • 79960085862 scopus 로고    scopus 로고
    • Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
    • Chmielecki J, Foo J, Oxnard GR, et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med. 2011; 3 (90): 90ra59.
    • (2011) Sci Transl Med. , vol.3 , Issue.90 , pp. 90ra59
    • Chmielecki, J.1    Foo, J.2    Oxnard, G.R.3
  • 64
    • 78650660439 scopus 로고    scopus 로고
    • Clinical responses to EGFRtyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: A retrospective analysis
    • Watanabe S, Tanaka J, Ota T, et al. Clinical responses to EGFRtyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis. BMC Cancer. 2011; 11 : 1.
    • (2011) BMC Cancer. , vol.11 , pp. 1
    • Watanabe, S.1    Tanaka, J.2    Ota, T.3
  • 65
    • 79952711946 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation
    • Oxnard GR, Arcila ME, Sima CS, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation . Clin Cancer Res. 2011; 17 (6): 1616-1622.
    • (2011) Clin Cancer Res. , vol.17 , Issue.6 , pp. 1616-1622
    • Oxnard, G.R.1    Arcila, M.E.2    Sima, C.S.3
  • 66
    • 84866751861 scopus 로고    scopus 로고
    • Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR - Mutant lung cancer [abstract]
    • Oxnard GR, Lo P, Jackman DM, et al. Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR - mutant lung cancer [abstract]. J Clin Oncol. 2012;30(suppl 491): 7547.
    • (2012) J Clin Oncol. , vol.30 , pp. 7547
    • Oxnard, G.R.1    Lo, P.2    Jackman, D.M.3
  • 67
    • 84915773642 scopus 로고    scopus 로고
    • LBA2-PR: Gefitinib/chemotherapy vs chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) after progression on first-line gefitinib: The phase III, randomized IMPRESS study
    • Mok TSK, Wu Y, Nakagawa W, et al. LBA2-PR: gefitinib/chemotherapy vs chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) after progression on first-line gefitinib: the phase III, randomized IMPRESS study. Ann Oncol. 2014;25(5):1-41.
    • (2014) Ann Oncol. , vol.25 , Issue.5 , pp. 1-41
    • Mok, T.S.K.1    Wu, Y.2    Nakagawa, W.3
  • 68
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]
    • Spigel DR, Ervin TJ, Ramlau R, et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]. J Clin Oncol. 2011 ;29(suppl):7505.
    • (2011) J Clin Oncol. , vol.29 , pp. 7505
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.3
  • 69
    • 84904679830 scopus 로고    scopus 로고
    • Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebocontrolled METLung (OAM4971g) global trial [abstract]
    • Spigel DR, Ervin TJ, O'Byrne K, et al. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: results from the pivotal phase III randomized, multicenter, placebocontrolled METLung (OAM4971g) global trial [abstract]. J Clin Oncol. 2014;32(suppl 5):8000.
    • (2014) J Clin Oncol. , vol.32 , pp. 8000
    • Spigel, D.R.1    Ervin, T.J.2    O'Byrne, K.3
  • 70
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007; 131 (6): 1190-1203.
    • (2007) Cell. , vol.131 , Issue.6 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 71
    • 84883451574 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced ROS1 -rearranged nonsmall cell lung cancer (NSCLC) [abstract]
    • Ou SHI, Bang Y-J, Camidge DR, et al. Efficacy and safety of crizotinib in patients with advanced ROS1 -rearranged nonsmall cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2013; 31 (suppl):8032.
    • (2013) J Clin Oncol. , vol.31 , pp. 8032
    • Ou, S.H.I.1    Bang, Y.-J.2    Camidge, D.R.3
  • 72
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Cancer Genome Project
    • Wan PT, Garnett MJ, Roe SM, et al; Cancer Genome Project. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004; 116 (6): 855-867.
    • (2004) Cell. , vol.116 , Issue.6 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3
  • 73
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol. 2011; 29 (26): 3574-3579.
    • (2011) J Clin Oncol. , vol.29 , Issue.26 , pp. 3574-3579
    • Marchetti, A.1    Felicioni, L.2    Malatesta, S.3
  • 74
    • 84884999688 scopus 로고    scopus 로고
    • Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients [abstract]
    • Planchard D, Mazieres J, Riely GJ, et al. Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients [abstract]. J Clin Oncol. 2013;31(suppl):8009.
    • (2013) J Clin Oncol. , vol.31 , pp. 8009
    • Planchard, D.1    Mazieres, J.2    Riely, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.