-
1
-
-
80555139776
-
Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC) [abstract]
-
Kris MG, Johnson BE, Kwiatkowski DJ, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: the NCI's Lung Cancer Mutation Consortium (LCMC) [abstract]. J Clin Oncol. 2011; 29 (suppl):CRA7506.
-
(2011)
J Clin Oncol.
, vol.29
, pp. CRA7506
-
-
Kris, M.G.1
Johnson, B.E.2
Kwiatkowski, D.J.3
-
2
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers [published correction in Nature. 2012;491(7426): 288]
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization of squamous cell lung cancers [published correction in Nature. 2012;491(7426):288]. Nature. 2012; 489 (7417): 519-525.
-
(2012)
Nature.
, vol.489
, Issue.7417
, pp. 519-525
-
-
-
3
-
-
53249145767
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
-
Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma . Clin Cancer Res. 2008; 14 (18): 5731-5734.
-
(2008)
Clin Cancer Res.
, vol.14
, Issue.18
, pp. 5731-5734
-
-
Riely, G.J.1
Kris, M.G.2
Rosenbaum, D.3
-
4
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004; 350 (21): 2129-2139.
-
(2004)
N Engl J Med.
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
5
-
-
78149470440
-
Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers
-
Lee SY, Kim MJ, Jin G, et al. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. J Thorac Oncol. 2010; 5 (11): 1734-1740.
-
(2010)
J Thorac Oncol.
, vol.5
, Issue.11
, pp. 1734-1740
-
-
Lee, S.Y.1
Kim, M.J.2
Jin, G.3
-
6
-
-
69349083935
-
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
-
Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res. 2009; 15 (16): 5216-5223.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.16
, pp. 5216-5223
-
-
Rodig, S.J.1
Mino-Kenudson, M.2
Dacic, S.3
-
7
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A. 2007; 104 (52): 20932-20937.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, Issue.52
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
8
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
Kawano O, Sasaki H, Endo K, et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer. 2006; 54 (2): 209-215.
-
(2006)
Lung Cancer.
, vol.54
, Issue.2
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
-
9
-
-
84857929267
-
KIF5B-RET fusions in lung adenocarcinoma
-
Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med. 2012; 18 (3): 375-377.
-
(2012)
Nat Med.
, vol.18
, Issue.3
, pp. 375-377
-
-
Kohno, T.1
Ichikawa, H.2
Totoki, Y.3
-
10
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012; 30 (8): 863-870.
-
(2012)
J Clin Oncol.
, vol.30
, Issue.8
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
-
11
-
-
84883022821
-
Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer
-
Cardarella S, Ogino A, Nishino M, et al. Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. Clin Cancer Res. 2013; 19 (16): 4532-4540.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.16
, pp. 4532-4540
-
-
Cardarella, S.1
Ogino, A.2
Nishino, M.3
-
12
-
-
79958112619
-
Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
-
Dutt A, Ramos AH, Hammerman PS, et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One. 2011; 6 (6): e20351.
-
(2011)
PLoS One.
, vol.6
, Issue.6
, pp. e20351
-
-
Dutt, A.1
Ramos, A.H.2
Hammerman, P.S.3
-
13
-
-
84877679631
-
Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines
-
Socinski MA, Evans T, Gettinger S, et al. Treatment of stage IV non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidencebased clinical practice guidelines. Chest. 2013 ;143(5-suppl): e341S-e368S.
-
(2013)
Chest.
, vol.143
, Issue.5
, pp. e341S-e368S
-
-
Socinski, M.A.1
Evans, T.2
Gettinger, S.3
-
14
-
-
69949162760
-
Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009; 361 (10): 947-957.
-
(2009)
N Engl J Med.
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
15
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica
-
Rosell R, Carcereny E, Gervais R, et al; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012; 13 (3): 239-246.
-
(2012)
Lancet Oncol.
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
16
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
-
Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012; 13 (5): 539-548.
-
(2012)
Lancet Oncol.
, vol.13
, Issue.5
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
-
17
-
-
84866655838
-
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations [abstract]
-
Yang JC-H, Schuler MH, Yamamoto N, et al. LUX-Lung 3: a randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations [abstract]. J Clin Oncol. 2012;30(suppl):LBA7500.
-
(2012)
J Clin Oncol.
, vol.30
, pp. LBA7500
-
-
Jc-H, Y.1
Schuler, M.H.2
Yamamoto, N.3
-
18
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010; 363(18): 1693-1703.
-
(2010)
N Engl J Med.
, vol.363
, Issue.18
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
19
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005; 97 (5): 339-346.
-
(2005)
J Natl Cancer Inst.
, vol.97
, Issue.5
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
20
-
-
33745307617
-
Ras PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006; 441 (7092): 424-430.
-
(2006)
Nature.
, vol.441
, Issue.7092
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
21
-
-
4143066760
-
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
-
Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science. 2004; 305 (5687): 1163-1167.
-
(2004)
Science.
, vol.305
, Issue.5687
, pp. 1163-1167
-
-
Sordella, R.1
Bell, D.W.2
Haber, D.A.3
Settleman, J.4
-
22
-
-
5644293135
-
Gefitinib induces apoptosis in the EGFRL858R non-smallcell lung cancer cell line H3255
-
Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Jänne PA. Gefitinib induces apoptosis in the EGFRL858R non-smallcell lung cancer cell line H3255. Cancer Res. 2004; 64 (20): 7241-7244.
-
(2004)
Cancer Res.
, vol.64
, Issue.20
, pp. 7241-7244
-
-
Tracy, S.1
Mukohara, T.2
Hansen, M.3
Meyerson, M.4
Johnson, B.E.5
Jänne, P.A.6
-
23
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005; 366 (9496): 1527-1537.
-
(2005)
Lancet.
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
24
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013; 31 (27): 3327-3334.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
25
-
-
84863892117
-
Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
-
Jänne PA, Wang X, Socinski MA, et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol. 2012; 30 (17): 2063-2069.
-
(2012)
J Clin Oncol.
, vol.30
, Issue.17
, pp. 2063-2069
-
-
Jänne, P.A.1
Wang, X.2
Socinski, M.A.3
-
26
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
West Japan Oncology Group
-
Mitsudomi T, Morita S, Yatabe Y, et al; West Japan Oncology Group. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010; 11 (2): 121-128.
-
(2010)
Lancet Oncol.
, vol.11
, Issue.2
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
27
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
North-East Japan Study Group
-
Maemondo M, Inoue A, Kobayashi K, et al; North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010; 362 (25): 2380-2388.
-
(2010)
N Engl J Med.
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
28
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutationpositive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutationpositive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011; 12 (8): 735-742.
-
(2011)
Lancet Oncol.
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
29
-
-
84892997539
-
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial
-
Wu Y-L, Zhou C, Hu CP, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014; 15 (2): 213-222.
-
(2014)
Lancet Oncol.
, vol.15
, Issue.2
, pp. 213-222
-
-
Wu, Y.-L.1
Zhou, C.2
Hu, C.P.3
-
30
-
-
84964698676
-
Management and future directions in non-small cell lung cancer with known activating mutations
-
Gerber D, Gandhi L, Costa DB. Management and future directions in non-small cell lung cancer with known activating mutations. Am Soc Clin Oncol Educ Book. 2014:e353-e365.
-
(2014)
Am Soc Clin Oncol Educ Book.
, pp. e353-e365
-
-
Gerber, D.1
Gandhi, L.2
Costa, D.B.3
-
31
-
-
84883055532
-
Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): A randomised controlled trial
-
TAILOR Trialists
-
Garassino MC, Martelli O, Broggini M, et al; TAILOR Trialists. Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol. 2013; 14 (10): 981-988.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.10
, pp. 981-988
-
-
Garassino, M.C.1
Martelli, O.2
Broggini, M.3
-
32
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
National Cancer Institute of Canada Clinical Trials Group
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005; 353 (2): 123-132.
-
(2005)
N Engl J Med.
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
33
-
-
84855310079
-
EGFR exon 20 insertion mutations in non-small-cell lung cancer: Preclinical data and clinical implications
-
Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol. 2012; 13 (1): e23-e31.
-
(2012)
Lancet Oncol.
, vol.13
, Issue.1
, pp. e23-e31
-
-
Yasuda, H.1
Kobayashi, S.2
Costa, D.B.3
-
34
-
-
75349110926
-
Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
-
Eck MJ, Yun CH. Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta. 2010 ;1804(3):559-566.
-
(2010)
Biochim Biophys Acta.
, vol.1804
, Issue.3
, pp. 559-566
-
-
Eck, M.J.1
Yun, C.H.2
-
35
-
-
74549120147
-
Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: A preliminary report
-
Girard N, Lou E, Azzoli CG, et al. Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report. Clin Cancer Res. 2010; 16 (2): 755-763.
-
(2010)
Clin Cancer Res.
, vol.16
, Issue.2
, pp. 755-763
-
-
Girard, N.1
Lou, E.2
Azzoli, C.G.3
-
36
-
-
28444455958
-
Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
-
Bell DW, Gore I, Okimoto RA, et al. Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR. Nat Genet. 2005; 37 (12): 1315-1316.
-
(2005)
Nat Genet.
, vol.37
, Issue.12
, pp. 1315-1316
-
-
Bell, D.W.1
Gore, I.2
Okimoto, R.A.3
-
37
-
-
79960856289
-
Drug-induced effects on erlotinib metabolism
-
Mir O, Blanchet B, Goldwasser F. Drug-induced effects on erlotinib metabolism. N Engl J Med. 2011; 365 (4): 379-380.
-
(2011)
N Engl J Med.
, vol.365
, Issue.4
, pp. 379-380
-
-
Mir, O.1
Blanchet, B.2
Goldwasser, F.3
-
38
-
-
33646238486
-
Effects of smoking on the pharmacokinetics of erlotinib
-
Hamilton M, Wolf JL, Rusk J, et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res. 2006; 12 (7): 2166-2171.
-
(2006)
Clin Cancer Res.
, vol.12
, Issue.7
, pp. 2166-2171
-
-
Hamilton, M.1
Wolf, J.L.2
Rusk, J.3
-
39
-
-
84857002194
-
BIM expression in treatmentnaive cancers predicts responsiveness to kinase inhibitors
-
Faber AC, Corcoran RB, Ebi H, et al. BIM expression in treatmentnaive cancers predicts responsiveness to kinase inhibitors. Cancer Discov. 2011; 1 (4): 352-365.
-
(2011)
Cancer Discov.
, vol.1
, Issue.4
, pp. 352-365
-
-
Faber, A.C.1
Corcoran, R.B.2
Ebi, H.3
-
40
-
-
84862777672
-
A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
-
Ng KP, Hillmer AM, Chuah CT, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med. 2012; 18(4): 521-528.
-
(2012)
Nat Med.
, vol.18
, Issue.4
, pp. 521-528
-
-
Ng, K.P.1
Hillmer, A.M.2
Chuah, C.T.3
-
41
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011; 3 (75): 75ra26.
-
(2011)
Sci Transl Med.
, vol.3
, Issue.75
, pp. 75ra26
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
42
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun CH, Mengwasser KE, Toms AV, et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A. 2008; 105 (6): 2070-2075.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, Issue.6
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
-
43
-
-
35648949422
-
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
-
Costa DB, Halmos B, Kumar A, et al. BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. PLoS Med. 2007; 4 (10): 1669-1679.
-
(2007)
PLoS Med.
, vol.4
, Issue.10
, pp. 1669-1679
-
-
Costa, D.B.1
Halmos, B.2
Kumar, A.3
-
44
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007; 316 (5827): 1039-1043.
-
(2007)
Science.
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
45
-
-
56449089812
-
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
-
Yano S, Wang W, Li Q, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 2008; 68 (22): 9479-9487.
-
(2008)
Cancer Res.
, vol.68
, Issue.22
, pp. 9479-9487
-
-
Yano, S.1
Wang, W.2
Li, Q.3
-
46
-
-
84864524696
-
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
-
Ohashi K, Sequist LV, Arcila ME, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A. 2012; 109 (31): E2127-E2133.
-
(2012)
Proc Natl Acad Sci U S A.
, vol.109
, Issue.31
, pp. E2127-E2133
-
-
Ohashi, K.1
Sequist, L.V.2
Arcila, M.E.3
-
47
-
-
84868010326
-
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors
-
Ercan D, Xu C, Yanagita M, et al. Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2012; 2 (10): 934-947.
-
(2012)
Cancer Discov.
, vol.2
, Issue.10
, pp. 934-947
-
-
Ercan, D.1
Xu, C.2
Yanagita, M.3
-
48
-
-
84864621910
-
Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers
-
Cheung HW, Du J, Boehm JS, et al. Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers. Cancer Discov. 2011; 1 (7): 608-625.
-
(2011)
Cancer Discov.
, vol.1
, Issue.7
, pp. 608-625
-
-
Cheung, H.W.1
Du, J.2
Boehm, J.S.3
-
49
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol. 2012; 13 (5): 528-538.
-
(2012)
Lancet Oncol.
, vol.13
, Issue.5
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
50
-
-
84904657511
-
First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations of EGFR (activating and T790M) [abstract]
-
Sequist LV, Soria J-C, Gadgeel SM, et al. First-in-human evaluation of CO-1686, an irreversible, highly selective tyrosine kinase inhibitor of mutations of EGFR (activating and T790M) [abstract]. J Clin Oncol. 2014;32(suppl 5):8010.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 8010
-
-
Sequist, L.V.1
Soria, J.-C.2
Gadgeel, S.M.3
-
51
-
-
84904624695
-
Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) [abstract]
-
Janne PA, Ramalingam SS, Yang JC-H, et al. Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients (pts) with EGFR inhibitor-resistant non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2014;32(suppl 5):8009.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 8009
-
-
Janne, P.A.1
Ramalingam, S.S.2
Jc-H, Y.3
-
52
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007; 448 (7153): 561-566.
-
(2007)
Nature.
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
53
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009; 27 (26): 4247-4253.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.26
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
54
-
-
78049426513
-
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
-
ALK Lung Cancer Study Group
-
Choi YL, Soda M, Yamashita Y, et al; ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010; 363 (18): 1734-1739.
-
(2010)
N Engl J Med.
, vol.363
, Issue.18
, pp. 1734-1739
-
-
Choi, Y.L.1
Soda, M.2
Yamashita, Y.3
-
55
-
-
79954592031
-
Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
-
Takezawa K, Okamoto I, Nishio K, Jänne PA, Nakagawa K. Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. Clin Cancer Res. 2011; 17 (8): 2140-2148.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.8
, pp. 2140-2148
-
-
Takezawa, K.1
Okamoto, I.2
Nishio, K.3
Jänne, P.A.4
Nakagawa, K.5
-
56
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013; 368 (25): 2385-2394.
-
(2013)
N Engl J Med.
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
57
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
Katayama R, Shaw AT, Khan TM, et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med. 2012; 4 (120): 120ra17.
-
(2012)
Sci Transl Med.
, vol.4
, Issue.120
, pp. 120ra17
-
-
Katayama, R.1
Shaw, A.T.2
Khan, T.M.3
-
58
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012 ;18(5):1472-1482.
-
(2012)
Clin Cancer Res.
, vol.18
, Issue.5
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
-
59
-
-
80052793410
-
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
-
Sasaki T, Koivunen J, Ogino A, et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res. 2011; 71 (18): 6051-6060.
-
(2011)
Cancer Res.
, vol.71
, Issue.18
, pp. 6051-6060
-
-
Sasaki, T.1
Koivunen, J.2
Ogino, A.3
-
60
-
-
81355124049
-
Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen
-
Zhang S, Wang F, Keats J, et al. Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011; 78 (6): 999-1005.
-
(2011)
Chem Biol Drug Des.
, vol.78
, Issue.6
, pp. 999-1005
-
-
Zhang, S.1
Wang, F.2
Keats, J.3
-
61
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw AT, Kim D-W, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014; 370 (13): 1189-1197.
-
(2014)
N Engl J Med.
, vol.370
, Issue.13
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.-W.2
Mehra, R.3
-
62
-
-
84877679409
-
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
-
Sang J, Acquaviva J, Friedland JC, et al. Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. Cancer Discov. 2013; 3 (4): 430-443.
-
(2013)
Cancer Discov.
, vol.3
, Issue.4
, pp. 430-443
-
-
Sang, J.1
Acquaviva, J.2
Friedland, J.C.3
-
63
-
-
79960085862
-
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
-
Chmielecki J, Foo J, Oxnard GR, et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Sci Transl Med. 2011; 3 (90): 90ra59.
-
(2011)
Sci Transl Med.
, vol.3
, Issue.90
, pp. 90ra59
-
-
Chmielecki, J.1
Foo, J.2
Oxnard, G.R.3
-
64
-
-
78650660439
-
Clinical responses to EGFRtyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: A retrospective analysis
-
Watanabe S, Tanaka J, Ota T, et al. Clinical responses to EGFRtyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis. BMC Cancer. 2011; 11 : 1.
-
(2011)
BMC Cancer.
, vol.11
, pp. 1
-
-
Watanabe, S.1
Tanaka, J.2
Ota, T.3
-
65
-
-
79952711946
-
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation
-
Oxnard GR, Arcila ME, Sima CS, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation . Clin Cancer Res. 2011; 17 (6): 1616-1622.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.6
, pp. 1616-1622
-
-
Oxnard, G.R.1
Arcila, M.E.2
Sima, C.S.3
-
66
-
-
84866751861
-
Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR - Mutant lung cancer [abstract]
-
Oxnard GR, Lo P, Jackman DM, et al. Delay of chemotherapy through use of post-progression erlotinib in patients with EGFR - mutant lung cancer [abstract]. J Clin Oncol. 2012;30(suppl 491): 7547.
-
(2012)
J Clin Oncol.
, vol.30
, pp. 7547
-
-
Oxnard, G.R.1
Lo, P.2
Jackman, D.M.3
-
67
-
-
84915773642
-
LBA2-PR: Gefitinib/chemotherapy vs chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) after progression on first-line gefitinib: The phase III, randomized IMPRESS study
-
Mok TSK, Wu Y, Nakagawa W, et al. LBA2-PR: gefitinib/chemotherapy vs chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) after progression on first-line gefitinib: the phase III, randomized IMPRESS study. Ann Oncol. 2014;25(5):1-41.
-
(2014)
Ann Oncol.
, vol.25
, Issue.5
, pp. 1-41
-
-
Mok, T.S.K.1
Wu, Y.2
Nakagawa, W.3
-
68
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]
-
Spigel DR, Ervin TJ, Ramlau R, et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]. J Clin Oncol. 2011 ;29(suppl):7505.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 7505
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
-
69
-
-
84904679830
-
Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebocontrolled METLung (OAM4971g) global trial [abstract]
-
Spigel DR, Ervin TJ, O'Byrne K, et al. Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: results from the pivotal phase III randomized, multicenter, placebocontrolled METLung (OAM4971g) global trial [abstract]. J Clin Oncol. 2014;32(suppl 5):8000.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 8000
-
-
Spigel, D.R.1
Ervin, T.J.2
O'Byrne, K.3
-
70
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007; 131 (6): 1190-1203.
-
(2007)
Cell.
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
71
-
-
84883451574
-
Efficacy and safety of crizotinib in patients with advanced ROS1 -rearranged nonsmall cell lung cancer (NSCLC) [abstract]
-
Ou SHI, Bang Y-J, Camidge DR, et al. Efficacy and safety of crizotinib in patients with advanced ROS1 -rearranged nonsmall cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2013; 31 (suppl):8032.
-
(2013)
J Clin Oncol.
, vol.31
, pp. 8032
-
-
Ou, S.H.I.1
Bang, Y.-J.2
Camidge, D.R.3
-
72
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Cancer Genome Project
-
Wan PT, Garnett MJ, Roe SM, et al; Cancer Genome Project. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004; 116 (6): 855-867.
-
(2004)
Cell.
, vol.116
, Issue.6
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
-
73
-
-
80053014471
-
Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
-
Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol. 2011; 29 (26): 3574-3579.
-
(2011)
J Clin Oncol.
, vol.29
, Issue.26
, pp. 3574-3579
-
-
Marchetti, A.1
Felicioni, L.2
Malatesta, S.3
-
74
-
-
84884999688
-
Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients [abstract]
-
Planchard D, Mazieres J, Riely GJ, et al. Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients [abstract]. J Clin Oncol. 2013;31(suppl):8009.
-
(2013)
J Clin Oncol.
, vol.31
, pp. 8009
-
-
Planchard, D.1
Mazieres, J.2
Riely, G.J.3
|