Cardiomyocyte mineralocorticoid receptor activation impairs acute cardiac functional recovery after ischemic insult

Hypertension

Volumn 66, Issue 5, 2015, Pages 970-977

  Bienvenu, Laura A ^a,b   Reichelt, Melissa E ^b   Morgan, James ^a   Fletcher, Elizabeth K ^a   Bell, James R ^b   Rickard, Amanda J ^a   Delbridge, Lea M ^b   Young, Morag J ^a  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

deoxycorticosterone; ischemia; mineralocorticoids; myocyte, cardiac; receptors, mineralocorticoid; reperfusion

Indexed keywords

CALCIUM ION; DEOXYCORTICOSTERONE; ELONGATION FACTOR 2 KINASE; ESTROGEN RECEPTOR; MINERALOCORTICOID RECEPTOR; PROTON; SODIUM CHLORIDE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CARDITIS; CELL DEATH; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; CORONARY ARTERY BLOOD FLOW; EXTRASYSTOLE; FEMALE; GENOTYPE; HEART ARRHYTHMIA; HEART CONTRACTION; HEART FUNCTION; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE RELAXATION; HEART RHYTHM; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART WEIGHT; MACROPHAGE; MOUSE; MUSCLE CONTRACTURE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VOLKMANN CONTRACTURE; WILD TYPE; ANIMAL; DEFICIENCY; DISEASE MODEL; GENETICS; HEART; KNOCKOUT MOUSE; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; SEX DIFFERENCE;

ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; HEART; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; RECEPTORS, ESTROGEN; RECEPTORS, MINERALOCORTICOID; RECOVERY OF FUNCTION; SEX FACTORS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 84943383684     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05981     Document Type: Article

References (31)

1. Swedberg K, Zannad F, McMurray JJ, Krum H, Van Veldhuisen DJ, Shi H, Vincent J, Pitt B, EMPHASIS-HF Study Investigators Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study. J Am Coll Cardiol 2012 59 1598 1603. doi: 10.1016/j.jacc.2011.11.063
2. Pitt B, Reichek N, Willenbrock R, Zannad F, Phillips RA, Roniker B, Kleiman J, Krause S, Burns D, Williams GH., Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study. Circulation 2003 108 1831 1838. doi: 10.1161/01.CIR.0000091405.00772.6E.
3. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J., The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999 341 709 717. doi: 10.1056/NEJM199909023411001
4. Barbato JC, Mulrow PJ, Shapiro JI, Franco-Saenz R., Rapid effects of aldosterone and spironolactone in the isolated working rat heart. Hypertension 2002 40 130 135
5. Barbato JC, Rashid S, Mulrow PJ, Shapiro JI, Franco-Saenz R., Mechanisms for aldosterone and spironolactone-induced positive inotropic actions in the rat heart. Hypertension 2004 44 751 757. doi: 10.1161/01.HYP.0000144466.11568.7e.
6. 2+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes. Cardiovasc Res 2011 90 105 112. doi: 10.1093/cvr/cvq379
7. Rougier JS, Muller O, Berger S, Centeno G, Schütz G, Firsov D, Abriel H., Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes. Pflugers Arch 2008 456 407 412. doi: 10.1007/s00424-007-0387-z.
8. Wenzel S, Tastan I, Abdallah Y, Schreckenberg R, Schlüter KD., Aldosterone improves contractile function of adult rat ventricular cardiomyocytes in a non-acute way: potential relationship to the calcium paradox of aldosteronism. Basic Res Cardiol 2010 105 247 256. doi: 10.1007/s00395-009-0059-6
9. Matsui S, Satoh H, Kawashima H, Nagasaka S, Niu CF, Urushida T, Katoh H, Watanabe Y, Hayashi H., Non-genomic effects of aldosterone on intracellular ion regulation and cell volume in rat ventricular myocytes. Can J Physiol Pharmacol 2007 85 264 273. doi: 10.1139/y07-017
10. Ouvrard-Pascaud A, Sainte-Marie Y, Bénitah JP, Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 2005 111 3025 3033. doi: 10.1161/CIRCULATIONAHA.104.503706
11. Fraccarollo D, Berger S, Galuppo P, Kneitz S, Hein L, Schütz G, Frantz S, Ertl G, Bauersachs J., Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation 2011 123 400 408. doi: 10.1161/CIRCULATIONAHA.110.983023
12. He BJ, Joiner ML, Singh MV, Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nat Med 2011 17 1610 1618. doi: 10.1038/nm.2506
13. Rickard AJ, Morgan J, Bienvenu LA, Fletcher EK, Cranston GA, Shen JZ, Reichelt ME, Delbridge LM, Young MJ., Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis. Hypertension 2012 60 1443 1450. doi: 10.1161/HYPERTENSIONAHA.112.203158
14. Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ., Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function. Endocrinology 2014 155 4461 4472. doi: 10.1210/en.2014-1270
15. Schmidt K, Tissier R, Ghaleh B, Drogies T, Felix SB, Krieg T., Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion. Eur Heart J 2010 31 1655 1662. doi: 10.1093/eurheartj/ehp555
16. Chai W, Garrelds IM, De Vries R, Danser AH., Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone? Hypertension 2006 47 665 670. doi: 10.1161/01.HYP.0000205831.39339.a5
17. Ayoub IM, Kolarova J, Yi Z, Trevedi A, Deshmukh H, Lubell DL, Franz MR, Maldonado FA, Gazmuri RJ., Sodium-hydrogen exchange inhibition during ventricular fibrillation: beneficial effects on ischemic contracture, action potential duration, reperfusion arrhythmias, myocardial function, and resuscitability. Circulation 2003 107 1804 1809. doi: 10.1161/01.CIR.0000058704.45646.0D.
18. 2+ sex and sex steroids. Clin Exp Pharmacol Physiol 2011 38 717 723. doi: 10.1111/j.1440-1681.2011.05567.x.
19. Vila-Petroff M, Mundiña-Weilenmann C, Lezcano N, Snabaitis AK, Huergo MA, Valverde CA, Avkiran M, Mattiazzi A., Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation. J Mol Cell Cardiol 2010 49 106 112. doi: 10.1016/j.yjmcc.2009.12.007
20. Vaughan-Jones RD, Spitzer KW, Swietach P., Intracellular pH regulation in heart. J Mol Cell Cardiol 2009 46 318 331. doi: 10.1016/j.yjmcc.2008.10.024
21. Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L., Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function. Hypertension 2011 57 746 754. doi: 10.1161/HYPERTENSIONAHA.110.163287
22. Parviz Y, Iqbal J, Pitt B, Adlam D, Al-Mohammad A, Zannad F., Emerging cardiovascular indications of mineralocorticoid receptor antagonists. Trends Endocrinol Metab 2015 26 201 211. doi: 10.1016/j.tem.2015.01.007
23. Silvestre JS, Robert V, Escoubet B, Heymes C, Oubénaïssa A, Desopper C, Swynghedauw B, Delcayre C., Different regulation of cardiac and renal corticosteroid receptors in aldosterone-salt treated rats: effect of hypertension and glucocorticoids. J Mol Cell Cardiol 2000 32 1249 1263. doi: 10.1006/jmcc.2000.1159
24. Loan Le TY, Mardini M, Howell VM, Funder JW, Ashton AW, Mihailidou AS., Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction. Hypertension 2012 59 1164 1169. doi: 10.1161/HYPERTENSIONAHA.111.190488
25. Arriza JL, Simerly RB, Swanson LW, Evans RM., The neuronal mineralocorticoid receptor as a mediator of glucocorticoid response. Neuron 1988 1 887 900
26. Funder JW, Pearce PT, Smith R, Smith AI., Mineralocorticoid action: Target tissue specificity is enzyme, not receptor, mediated. Science 1988 242 583 585
27. Lombès M, Alfaidy N, Eugene E, Lessana A, Farman N, Bonvalet JP., Prerequisite for cardiac aldosterone action. Mineralocorticoid receptor and 11 beta-hydroxysteroid dehydrogenase in the human heart. Circulation 1995 92 175 182
28. Odermatt A, Kratschmar DV., Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases: An overview. Mol Cell Endocrinol 2012 350 168 186. doi: 10.1016/j.mce.2011.07.020
29. Mihailidou AS, Loan Le TY, Mardini M, Funder JW., Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction. Hypertension 2009 54 1306 1312. doi: 10.1161/HYPERTENSIONAHA.109.136242
30. Nagase M, Ayuzawa N, Kawarazaki W, Ishizawa K, Ueda K, Yoshida S, Fujita T., Oxidative stress causes mineralocorticoid receptor activation in rat cardiomyocytes: role of small GTPase Rac1. Hypertension 2012 59 500 506. doi: 10.1161/HYPERTENSIONAHA.111.185520
31. Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ., Aldosterone promotes vascular remodeling by direct effects on smooth muscle cell mineralocorticoid receptors. Arterioscler Thromb Vasc Biol 2014 34 355 364. doi: 10.1161/ATVBAHA.113.302854