메뉴 건너뛰기




Volumn 1345, Issue 1, 2015, Pages 67-73

Issues encountered in recent attempts to develop novel antidepressant agents

Author keywords

Antidepressants; Glutamate; Ketamine; Major depression; Onabotulinumtoxin

Indexed keywords

AGOMELATINE; ANTIDEPRESSANT AGENT; BOTULINUM TOXIN A; GLUCOCORTICOID ANTAGONIST; KETAMINE; MELATONIN RECEPTOR AGONIST; SEROTONIN 2 ANTAGONIST; VILAZODONE; VORTIOXETINE; BENZOFURAN DERIVATIVE; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SULFIDE;

EID: 84943378191     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12716     Document Type: Article
Times cited : (12)

References (44)
  • 1
    • 57049188862 scopus 로고    scopus 로고
    • Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD
    • Papakostas, G.I. & M. Fava . 2009. Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD. Eur. Neuropsychopharm. 19: 34-40.
    • (2009) Eur. Neuropsychopharm , vol.19 , pp. 34-40
    • Papakostas, G.I.1    Fava, M.2
  • 2
    • 0037051872 scopus 로고    scopus 로고
    • Placebo response in studies of major depression: variable, substantial, and growing
    • Walsh, B.T., S.N. Seidman, R. Sysko, et al. 2002. Placebo response in studies of major depression: variable, substantial, and growing. JAMA 287: 1840-1847.
    • (2002) JAMA , vol.287 , pp. 1840-1847
    • Walsh, B.T.1    Seidman, S.N.2    Sysko, R.3
  • 3
    • 80052999964 scopus 로고    scopus 로고
    • Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant
    • Laughren, T.P., J. Gobburu, R.J. Temple, et al. 2011. Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant. J. Clin. Psychiatry 72: 1166-1173.
    • (2011) J. Clin. Psychiatry , vol.72 , pp. 1166-1173
    • Laughren, T.P.1    Gobburu, J.2    Temple, R.J.3
  • 4
    • 84862132965 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
    • Katona, C., T. Hansen & C.K. Olsen . 2012. A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int. Clin. Psychopharmacol. 27: 215-223.
    • (2012) Int. Clin. Psychopharmacol. , vol.27 , pp. 215-223
    • Katona, C.1    Hansen, T.2    Olsen, C.K.3
  • 5
    • 84938074907 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults
    • McIntyre, R.S., S. Lophaven & C.K. Olsen . 2014. A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults. Int. J. Neuropsychopharmacol. 17: 1557-1567.
    • (2014) Int. J. Neuropsychopharmacol. , vol.17 , pp. 1557-1567
    • McIntyre, R.S.1    Lophaven, S.2    Olsen, C.K.3
  • 6
    • 34250832737 scopus 로고    scopus 로고
    • Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial
    • Raskin, J., C.G. Wiltse, A. Siegal, et al. 2007. Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial. Am. J. Psychiatry 164: 900-909.
    • (2007) Am. J. Psychiatry , vol.164 , pp. 900-909
    • Raskin, J.1    Wiltse, C.G.2    Siegal, A.3
  • 7
    • 84949103662 scopus 로고    scopus 로고
    • (lisdexamfetamine dimesylate) Capsules (CII) as an Adjunctive Treatment for Adults with Major Depressive Disorder. Press Release, February 6
    • Shire Reports Top-line Results from Two Phase 3 Studies for Vyvanse® (lisdexamfetamine dimesylate) Capsules (CII) as an Adjunctive Treatment for Adults with Major Depressive Disorder. Press Release, February 6, 2014.
    • (2014) Shire Reports Top-line Results from Two Phase 3 Studies for Vyvanse®
  • 9
    • 0033969685 scopus 로고    scopus 로고
    • Antidepressant effects of ketamine in depressed patients
    • Berman, R.M., A. Cappiello, A. Anand, et al. 2000. Antidepressant effects of ketamine in depressed patients. Biol. Psychiatry 47: 351-354.
    • (2000) Biol. Psychiatry , vol.47 , pp. 351-354
    • Berman, R.M.1    Cappiello, A.2    Anand, A.3
  • 10
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression
    • Zarate, C.A., Jr., J.B. Singh, P.J. Carlson, et al. 2006. A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch. Gen. Psychiatry 63: 856-864.
    • (2006) Arch. Gen. Psychiatry , vol.63 , pp. 856-864
    • Zarate, C.A.1    Singh, J.B.2    Carlson, P.J.3
  • 11
    • 84885214350 scopus 로고    scopus 로고
    • Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
    • Murrough, J.W., D.V. Iosifescu, L.C. Chang, et al. 2013. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am. J. Psychiatry 170: 1134-1142.
    • (2013) Am. J. Psychiatry , vol.170 , pp. 1134-1142
    • Murrough, J.W.1    Iosifescu, D.V.2    Chang, L.C.3
  • 12
    • 84895744144 scopus 로고    scopus 로고
    • Do the dissociative side effects of ketamine mediate its antidepressant effects?
    • Luckenbaugh, D.A., M.J. Niciu, D.F. Ionescu, et al. 2014. Do the dissociative side effects of ketamine mediate its antidepressant effects? J. Affect. Disord. 159: 56-61.
    • (2014) J. Affect. Disord , vol.159 , pp. 56-61
    • Luckenbaugh, D.A.1    Niciu, M.J.2    Ionescu, D.F.3
  • 13
    • 84880767967 scopus 로고    scopus 로고
    • Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression
    • Murrough, J.W., A.M. Perez, S. Pillemer, et al. 2013. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol. Psychiatry 74: 250-256.
    • (2013) Biol. Psychiatry , vol.74 , pp. 250-256
    • Murrough, J.W.1    Perez, A.M.2    Pillemer, S.3
  • 14
    • 77949625234 scopus 로고    scopus 로고
    • Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
    • Mathew, S.J., J.W. Murrough, M. aan het Rot, et al. 2010. Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. Int. J. Neuropsychopharmacol. 13: 71-82.
    • (2010) Int. J. Neuropsychopharmacol , vol.13 , pp. 71-82
    • Mathew, S.J.1    Murrough, J.W.2    aan het Rot, M.3
  • 15
    • 30044450251 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of memantine in the treatment of major depression
    • Zarate, C.A., Jr., J.B. Singh, J.A. Quiroz, et al. 2006. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am. J. Psychiatry 163: 153-155.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 153-155
    • Zarate, C.A.1    Singh, J.B.2    Quiroz, J.A.3
  • 16
    • 84887043337 scopus 로고    scopus 로고
    • Antidepressant augmentation using the N-methyl-d-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial
    • Smith, E.G., K.M. Deligiannidis, C.M. Ulbricht, et al. 2013. Antidepressant augmentation using the N-methyl-d-aspartate antagonist memantine: a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry 74: 966-973.
    • (2013) J. Clin. Psychiatry , vol.74 , pp. 966-973
    • Smith, E.G.1    Deligiannidis, K.M.2    Ulbricht, C.M.3
  • 17
    • 84908572031 scopus 로고    scopus 로고
    • Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
    • Sanacora, G., M.A. Smith, S. Pathak, et al. 2013. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol. Psychiatry 19: 978-985.
    • (2013) Mol. Psychiatry , vol.19 , pp. 978-985
    • Sanacora, G.1    Smith, M.A.2    Pathak, S.3
  • 18
    • 84941036014 scopus 로고    scopus 로고
    • Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequent response to antidepressants: primary results from a randomized, placebocontrolled study (PURSUIT)
    • Hollywood, FL.
    • Sanacora, G., A. Khan, S. Atkinson, et al. 2014. Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequent response to antidepressants: primary results from a randomized, placebocontrolled study (PURSUIT). Presented at American Society of Clinical Psychiatry, Hollywood, FL.
    • (2014) Presented at American Society of Clinical Psychiatry
    • Sanacora, G.1    Khan, A.2    Atkinson, S.3
  • 19
    • 84949095143 scopus 로고    scopus 로고
    • A phase 2, randomized single blind, single intravenous dose of GLYX-12, an NMDA receptor glycine site functional partial agonist, in subjects with major depressive disorder with inadequate response to antidepressant medication
    • Hollywood, FL.
    • Burch, R. 2012. A phase 2, randomized single blind, single intravenous dose of GLYX-12, an NMDA receptor glycine site functional partial agonist, in subjects with major depressive disorder with inadequate response to antidepressant medication. Presented at 51st Annual Meeting, American College of Neuropyschopharmacology, Hollywood, FL.
    • (2012) Presented at 51st Annual Meeting, American College of Neuropyschopharmacology
    • Burch, R.1
  • 20
    • 84886644646 scopus 로고    scopus 로고
    • Inhibition of glycine transporter-I as a novel mechanism for the treatment of depression
    • Huang, C.C., I.H. Wei, C.L. Huang, et al. 2013. Inhibition of glycine transporter-I as a novel mechanism for the treatment of depression. Biol. Psychiatry 74: 734-741.
    • (2013) Biol. Psychiatry , vol.74 , pp. 734-741
    • Huang, C.C.1    Wei, I.H.2    Huang, C.L.3
  • 21
    • 84874654554 scopus 로고    scopus 로고
    • A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression
    • Heresco-Levy, U., G. Gelfin, B. Bloch, et al. 2013. A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression. Int. J. Neuropsychopharmacol. 16: 501-506.
    • (2013) Int. J. Neuropsychopharmacol , vol.16 , pp. 501-506
    • Heresco-Levy, U.1    Gelfin, G.2    Bloch, B.3
  • 22
    • 84898747772 scopus 로고    scopus 로고
    • A word to the wise about ketamine
    • Schatzberg, A.F. 2014. A word to the wise about ketamine. Am. J. Psychiatry 171: 262-264.
    • (2014) Am. J. Psychiatry , vol.171 , pp. 262-264
    • Schatzberg, A.F.1
  • 23
    • 84856025168 scopus 로고    scopus 로고
    • Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors
    • Mehta, A.K., S. Halder, N. Khanna, et al. 2012. Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors. Hum. Exp. Toxicol. 31: 51-56.
    • (2012) Hum. Exp. Toxicol , vol.31 , pp. 51-56
    • Mehta, A.K.1    Halder, S.2    Khanna, N.3
  • 24
    • 84906958262 scopus 로고    scopus 로고
    • Participation of AT1 and Mas receptors in the modulation of inflammatory pain
    • Costa, A.C., T.R. Romero, D.F. Pacheco, et al. 2014. Participation of AT1 and Mas receptors in the modulation of inflammatory pain. Peptides 61: 17-22.
    • (2014) Peptides , vol.61 , pp. 17-22
    • Costa, A.C.1    Romero, T.R.2    Pacheco, D.F.3
  • 25
    • 84899618176 scopus 로고    scopus 로고
    • Rapid antidepressant effects and abuse liability of ketamine
    • Yang, C. & K. Hashimoto . 2014. Rapid antidepressant effects and abuse liability of ketamine. Psychopharmacology 231: 2041-2042.
    • (2014) Psychopharmacology , vol.231 , pp. 2041-2042
    • Yang, C.1    Hashimoto, K.2
  • 26
    • 77955909841 scopus 로고    scopus 로고
    • mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    • Li, N., B. Lee, R.J. Liu, et al. 2010. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329: 959-964.
    • (2010) Science , vol.329 , pp. 959-964
    • Li, N.1    Lee, B.2    Liu, R.J.3
  • 27
    • 33846271423 scopus 로고    scopus 로고
    • Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial
    • O'Reardon, J.P., H.B. Solvason, P.G. Janicak, et al. 2007. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatry 62: 1208-1216.
    • (2007) Biol. Psychiatry , vol.62 , pp. 1208-1216
    • O'Reardon, J.P.1    Solvason, H.B.2    Janicak, P.G.3
  • 28
    • 84863436099 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice
    • Carpenter, L.L., P.G. Janicak, S.T. Aaronson, et al. 2012. Transcranial magnetic stimulation (TMS) for major depression: a multisite, naturalistic, observational study of acute treatment outcomes in clinical practice. Depress. Anxiety 29: 587-596.
    • (2012) Depress. Anxiety , vol.29 , pp. 587-596
    • Carpenter, L.L.1    Janicak, P.G.2    Aaronson, S.T.3
  • 29
    • 84949108923 scopus 로고    scopus 로고
    • New approach to depression
    • The New York Times.
    • Rabin, R.C. 2013. New approach to depression. The New York Times.
    • (2013)
    • Rabin, R.C.1
  • 30
    • 14644402983 scopus 로고    scopus 로고
    • Deep brain stimulation for treatment-resistant depression
    • Mayberg, H.S., A.M. Lozano, V. Voon, et al. 2005. Deep brain stimulation for treatment-resistant depression. Neuron 45: 651-660.
    • (2005) Neuron , vol.45 , pp. 651-660
    • Mayberg, H.S.1    Lozano, A.M.2    Voon, V.3
  • 31
    • 84856757431 scopus 로고    scopus 로고
    • Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression
    • Holtzheimer, P.E., M.E. Kelley, R.E. Gross, et al. 2012. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch. Gen. Psychiatry 69: 150-158.
    • (2012) Arch. Gen. Psychiatry , vol.69 , pp. 150-158
    • Holtzheimer, P.E.1    Kelley, M.E.2    Gross, R.E.3
  • 32
    • 84900825260 scopus 로고    scopus 로고
    • Deep brain stimulation of the human reward system for major depression-rationale, outcomes and outlook
    • Schlaepfer, T.E., B.H. Bewernick, S. Kayser, et al. Deep brain stimulation of the human reward system for major depression-rationale, outcomes and outlook. Neuropsychopharmacology 39: 1303-1314.
    • Neuropsychopharmacology , vol.39 , pp. 1303-1314
    • Schlaepfer, T.E.1    Bewernick, B.H.2    Kayser, S.3
  • 33
    • 84858958438 scopus 로고    scopus 로고
    • Facing depression with botulinum toxin: a randomized controlled trial
    • Wollmer, M.A., C. deBoer, N. Kalak, et al. 2012. Facing depression with botulinum toxin: a randomized controlled trial. J. Psychiatr. Res. 46: 574-581.
    • (2012) J. Psychiatr. Res. , vol.46 , pp. 574-581
    • Wollmer, M.A.1    de Boer, C.2    Kalak, N.3
  • 34
    • 84895886129 scopus 로고    scopus 로고
    • Treatment of depression with onabotulinumtoxin A: a randomized, double-blind, placebo controlled trial
    • Finzi, E. & N.E. Rosenthal . 2014. Treatment of depression with onabotulinumtoxin A: a randomized, double-blind, placebo controlled trial. J. Psychiatr. Res. 52: 1-6.
    • (2014) J. Psychiatr. Res. , vol.52 , pp. 1-6
    • Finzi, E.1    Rosenthal, N.E.2
  • 35
    • 84905159054 scopus 로고    scopus 로고
    • The face of negative affect: trial-by-trial corrugator responses to negative pictures are positively associated with amygdala and negatively associated with ventromedial prefrontal cortex activity
    • Heller, A.S., R.C. Lapate, K.E. Mayer, et al. 2014. The face of negative affect: trial-by-trial corrugator responses to negative pictures are positively associated with amygdala and negatively associated with ventromedial prefrontal cortex activity. J. Cogn. Neurosci. 26: 2102-2110.
    • (2014) J. Cogn. Neurosci , vol.26 , pp. 2102-2110
    • Heller, A.S.1    Lapate, R.C.2    Mayer, K.E.3
  • 36
    • 84920854307 scopus 로고    scopus 로고
    • Anna-Monika Award Lecture, DGPPN Kongress, 2013: the role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression
    • Schatzberg, A.F. 2014. Anna-Monika Award Lecture, DGPPN Kongress, 2013: the role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression. World J. Biol. Psychiatry 16: 2-11.
    • (2014) World J. Biol. Psychiatry , vol.16 , pp. 2-11
    • Schatzberg, A.F.1
  • 38
    • 33244489555 scopus 로고    scopus 로고
    • Clinical and biological effects of mifepristone treatment for psychotic depression
    • Flores, B.H., H. Kenna, J. Keller, et al. 2006. Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology 31: 628-636.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 628-636
    • Flores, B.H.1    Kenna, H.2    Keller, J.3
  • 39
    • 33750483274 scopus 로고    scopus 로고
    • Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression
    • DeBattista, C., J. Belanoff, S. Glass, et al. 2006. Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression. Biol. Psychiatry 60: 1343-1349.
    • (2006) Biol. Psychiatry , vol.60 , pp. 1343-1349
    • DeBattista, C.1    Belanoff, J.2    Glass, S.3
  • 40
    • 79960612871 scopus 로고    scopus 로고
    • Efficacy and safety of mifepristone for the treatment of psychotic depression
    • Blasey, C.M., T.S. Block, J.K. Belanoff, et al. 2011. Efficacy and safety of mifepristone for the treatment of psychotic depression. J. Clin. Psychopharmacol. 31: 436-440.
    • (2011) J. Clin. Psychopharmacol , vol.31 , pp. 436-440
    • Blasey, C.M.1    Block, T.S.2    Belanoff, J.K.3
  • 41
    • 84868215259 scopus 로고    scopus 로고
    • A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression
    • Watson, S., P. Gallagher, R.J. Porter, et al. 2012. A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression. Biol. Psychiatry 72: 943-949.
    • (2012) Biol. Psychiatry , vol.72 , pp. 943-949
    • Watson, S.1    Gallagher, P.2    Porter, R.J.3
  • 42
    • 73749086978 scopus 로고    scopus 로고
    • A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker?
    • Buckley, T.M. & A.F. Schatzberg . 2010. A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker? J. Psychiatr. Res. 44: 69-74.
    • (2010) J. Psychiatr. Res. , vol.44 , pp. 69-74
    • Buckley, T.M.1    Schatzberg, A.F.2
  • 43
    • 77952156000 scopus 로고    scopus 로고
    • Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial
    • Zajecka, J., A.F. Schatzberg, S. Stahl, et al. 2010. Efficacy and safety of agomelatine in the treatment of major depressive disorder: a multicenter, randomized, double-blind, placebo-controlled trial. J. Clin. Psychopharmacol. 30: 135-144.
    • (2010) J. Clin. Psychopharmacol , vol.30 , pp. 135-144
    • Zajecka, J.1    Schatzberg, A.F.2    Stahl, S.3
  • 44
    • 84883478692 scopus 로고    scopus 로고
    • Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials
    • Koesters, M., G. Guaiana, A. Cipriani, et al. 2013. Agomelatine efficacy and acceptability revisited: systematic review and meta-analysis of published and unpublished randomised trials. Br. J. Psychiatry 203: 179-187.
    • (2013) Br. J. Psychiatry , vol.203 , pp. 179-187
    • Koesters, M.1    Guaiana, G.2    Cipriani, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.