A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression

Biological Psychiatry

Volumn 72, Issue 11, 2012, Pages 943-949

  Watson, Stuart ^a   Gallagher, Peter ^a   Porter, Richard J ^e   Smith, Margaret S ^a   Herron, Lisa J ^a   Bulmer, Samantha ^a   Young, Allan H ^c,d   Ferrier, I Nicol ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b TYNE AND WEAR NHS FOUNDATION TRUST   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d LEEDS AND YORK PARTNERSHIP NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Bipolar disorder; glucocorticoid receptor; mifepristone; neuropsychological; progesterone; spatial working memory (SWM)

Indexed keywords

HYDROCORTISONE; MIFEPRISTONE; PLACEBO;

ADJUVANT THERAPY; ARTICLE; BIPOLAR DEPRESSION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; MOOD; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AFFECT; ATTENTION; BIPOLAR DISORDER; DOUBLE-BLIND METHOD; EXECUTIVE FUNCTION; FEMALE; HORMONE ANTAGONISTS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; MIFEPRISTONE; NEUROPSYCHOLOGICAL TESTS; PITUITARY-ADRENAL SYSTEM; TREATMENT OUTCOME; VERBAL LEARNING;

EID: 84868215259     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.05.029     Document Type: Article

References (49)

1. S. Watson, P. Gallagher, J.C. Ritchie, I.N. Ferrier, A.H. Young Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder Br J Psychiatry 184 2004 496 502
2. E.A. Young, M. Altemus, J.F. Lopez, J.H. Kocsis, A.F. Schatzberg, C. DeBattista HPA axis activation in major depression and response to fluoxetine: A pilot study Psychoneuroendocrinology 29 2004 1198 1204
3. M.F. Juruena, C.M. Pariante, A.S. Papadopoulos, L. Poon, S. Lightman, A.J. Cleare The prednisolone suppression test in depression: Prospective study of the role of HPA axis dysfunction in treatment resistance Br J Psychiatry 194 2009 342 349
4. M. Ising, S. Horstmann, S. Kloiber, S. Lucae, E.B. Binder, N. Kern Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biol Psychiatry 62 2007 47 54
5. S.E. Gartside, M.M. Leitch, A.H. Young Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: Implications for the treatment of depression Neuropsychopharmacol 28 2003 1572 1578
6. D.A. Johnson, C.D. Ingram, E.J. Grant, M. Craighead, S.E. Gartside Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter Neuropsychopharmacol 34 2009 399 409
7. L.J. Robinson, J.M. Thompson, P. Gallagher, U. Goswami, A.H. Young, I.N. Ferrier A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder J Affect Disord 93 2006 105 115
8. B. Arts, N. Jabben, L. Krabbendam, J. van Os Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives Psychol Med 38 2008 771 785
9. J.M. Thompson, P. Gallagher, J.H. Hughes, S. Watson, J.M. Gray, I.N. Ferrier Neurocognitive impairment in euthymic patients with bipolar affective disorder Br J Psychiatry 186 2005 32 40
10. S. Watson, J.M. Thompson, J.C. Ritchie, I. Nicol Ferrier, A.H. Young Neuropsychological impairment in bipolar disorder: The relationship with glucocorticoid receptor function Bipolar Disord 8 2006 85 90
11. K.E. Burdick, J.F. Goldberg, M. Harrow Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up Acta Psychiatr Scand 122 2010 499 506
12. G.S. Malhi, B. Ivanovski, D. Hadzi-Pavlovic, P.B. Mitchell, E. Vieta, P. Sachdev Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia Bipolar Disord 9 2007 114 125
13. K.E. Burdick, T.E. Goldberg, B.A. Cornblatt, R.S. Keefe, C.B. Gopin, P. DeRosse The MATRICS consensus cognitive battery in patients with bipolar I disorder Neuropsychopharmacol 36 2011 1587 1592
14. K.E. Burdick, R.J. Braga, J.F. Goldberg, A.K. Malhotra Cognitive dysfunction in bipolar disorder: Future place of pharmacotherapy CNS Drugs 21 2007 971 981
15. F. Spiga, D.M. Knight, S.K. Droste, B. Conway-Campbell, Y. Kershaw, C.P. MacSweeney Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding J Psychopharmacol 25 2011 211 221
16. M.S. Oitzl, M. Fluttert, W. Sutanto, E.R. de Kloet Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats Eur J Neurosci 10 1998 3759 3766
17. A.H. Young, P. Gallagher, S. Watson, D. Del-Estal, B.M. Owen, I.N. Ferrier Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder Neuropsychopharmacol 29 2004 1538 1545
18. C.M. Blasey, T.S. Block, J.K. Belanoff, R.L. Roe Efficacy and safety of mifepristone for the treatment of psychotic depression J Clin Psychopharmacol 31 2011 436 440
19. C.G. Bachmann, A.C. Linthorst, F. Holsboer, J.M. Reul Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis Neuropsychopharmacol 28 2003 1056 1067
20. J.K. Belanoff, B.H. Flores, M. Kalezhan, B. Sund, A.F. Schatzberg Rapid reversal of psychotic depression using mifepristone J Clin Psychopharmacol 21 2001 516 521
21. J.K. Belanoff, A.J. Rothschild, F. Cassidy, C. DeBattista, E.E. Baulieu, C. Schold An open label trial of C-1073 (mifepristone) for psychotic major depression Biol Psychiatry 52 2002 386 392
22. M.B. First, R.L. Spitzer, J.B.W. Williams, M. Gibbon Structured Clinical Interview for DSM-IV (SCID-I), Research Version 1995 Biometrics Research Department, New York State Psychiatric Institute New York
23. M.D. Lezak Neuropsychological Assessment 3rd ed. 1995 Oxford University Press New York
24. E.A. Shirtcliff, D.A. Granger, E. Schwartz, M.J. Curran Use of salivary biomarkers in biobehavioral research: Cotton-based sample collection methods can interfere with salivary immunoassay results Psychoneuroendocrinology 26 2001 165 173
25. P. Gallagher, M.M. Leitch, A.E. Massey, R.H. McAllister-Williams, A.H. Young Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: Effects of collection method J Psychopharmacol 20 2006 643 649
26. J. Cohen Statistical Power Analysis for the Behavioural Sciences 2nd ed. 1988 Lawrence Erlbaum Associates Mahwah, New Jersey
27. SPSS SPSS for Windows Version 9 9th ed. 1998 SPSS Chicago
28. G.M. Simpson, A. El Sheshai, N. Loza, S.J. Kingsbury, M. Fayek, A. Rady An 8-week open-label trial of a 6-day course of mifepristone for the treatment of psychotic depression J Clin Psychiatry 66 2005 598 602
29. B.H. Flores, H. Kenna, J. Keller, H.B. Solvason, A.F. Schatzberg Clinical and biological effects of mifepristone treatment for psychotic depression Neuropsychopharmacology 31 2005 628 636
30. C. DeBattista, J. Belanoff, S. Glass, A. Khan, R.L. Horne, C. Blasey Mifepristone versus placebo in the treatment of psychosis in patients with psychotic major depression Biol Psychiatry 60 2006 1343 1349
31. C.M. Blasey, C. DeBattista, R. Roe, T. Block, J.K. Belanoff A multisite trial of mifepristone for the treatment of psychotic depression: A site-by-treatment interaction Contemp Clin Trials 30 2009 284 288
32. G. Paslakis, B. Krumm, M. Gilles, U. Schweiger, I. Heuser, I. Richter Discrimination between patients with melancholic depression and healthy controls: Comparison between 24-h cortisol profiles, the DST and the Dex/CRH test Psychoneuroendocrinology 36 2011 691 698
33. P. Gallagher, S. Watson, C. Elizabeth Dye, A.H. Young, I. Nicol Ferrier Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia J Psychiatr Res 42 2008 1037 1041
34. M. van Asselen, R.P.C. Kessels, S.F.W. Neggers, L.J. Kappelle, C.J.M. Frijns, A. Postma Brain areas involved in spatial working memory Neuropsychologia 44 2006 1185 1194
35. W. Deng, J.B. Aimone, F.H. Gage New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11 2010 339 350
36. E. Gould, C.S. Woolley, B.S. McEwen Adrenal steroids regulate postnatal development of the rat dentate gyrus: I Effects of glucocorticoids on cell death J Comp Neurol 313 1991 479 485
37. E.Y.H. Wong, J. Herbert Roles of mineralocorticoid and glucocorticoid receptors in the regulation of progenitor proliferation in the adult hippocampus Eur J Neurosci 22 2005 785 792
38. C.A. Oomen, J.L. Mayer, E.R. De Kloet, M. Joëls, P.J. Lucassen Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stress Eur J Neurosci 26 2007 3395 3401
39. J.L. Mayer, L. Klumpers, S. Maslam, E.R. De Kloet, M. Joëls, P.J. Lucassen Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis J Neuroendocrinol 18 2006 629 631
40. M. Lai, K. Horsburgh, S.-E. Bae, R.N. Carter, D.J. Stenvers, J.H. Fowler Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia Eur J Neurosci 25 2007 1832 1842
41. V. Brinks, M.H. van der Mark, E.R. de Kloet, M.S. Oitzl Differential MR/GR activation in mice results in emotional states beneficial or impairing for cognition Neural Plast 2007 2007 90163
42. M. Joëls, H. Karst, R. DeRijk, E.R. de Kloet The coming out of the brain mineralocorticoid receptor Trends Neurosci 31 2008 1 7
43. Y. Revsin, N.V. Rekers, M.C. Louwe, F.E. Saravia, A.F. De Nicola, E.R. de Kloet Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice Neuropsychopharmacol 34 2008 747 758
44. N.N. Sarkar Mifepristone: bioavailability, pharmacokinetics and use-effectiveness Eur J Obstet Gynecol Reprod Biol 101 2002 113 120
45. P.O. Wilkinson, I.M. Goodter Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: A vulnerability model for depressive disorders Dev Psychopathol 23 2011 1017 1037
46. M.C. Lewis, P.T. Orr, K.M. Frick Differential effects of acute progesterone administration on spatial and object memory in middle-aged and aged female C57BL/6 mice Horm Behav 54 2008 455 462
47. W.L. Sun, V.N. Luine, L. Zhou, H.B. Wu, K.M. Weierstall, S. Jenab Acute progesterone treatment impairs spatial working memory in intact male and female rats 20 suppl 1 2010 S1-83S1-87
48. S.A. Farr, J.F. Flood, J.F. Scherrer, F.E. Kaiser, G.T. Taylor, J.E. Morley Effect of ovarian steroids on footshock avoidance learning and retention in female mice Physiol Behav 58 1995 715 723
49. I.-M. Johansson, V. Birzniece, C. Lindblad, T. Olsson, T. Bäckström Allopregnanolone inhibits learning in the Morris water maze Brain Res 934 2002 125 131