Mechanistic investigations of the hydrolysis of amides, oxoesters and thioesters via kinetic isotope effects and positional isotope exchange

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 11, 2015, Pages 1756-1767

  Robins, Lori I ^a   Fogle, Emily J ^b   Marlier, John F ^b  

^a UNIVERSITY OF WASHINGTON BOTHELL   (United States)

^b CALIFORNIA POLYTECHNIC STATE UNIVERSITY   (United States)

Author keywords

Amide hydrolysis mechanisms; Kinetic isotope effects; Oxoester hydrolysis mechanisms; Positional isotope exchange; Thioester hydrolysis mechanisms

Indexed keywords

AMIDE; CHOLINESTERASE; CHYMOTRYPSIN; ESTER DERIVATIVE; FORMAMIDE; FORMIC ACID DERIVATIVE; HYDROXYUREA; ISOTOPE; OXOESTER; THIOESTER; UNCLASSIFIED DRUG; UREASE; ENZYME; ESTER; OXYGEN;

CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME MECHANISM; HYDROLYSIS; POSITIONAL ISOTOPE EXCHANGE; PRIORITY JOURNAL; REVIEW; BIOCATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; METABOLISM; PH;

AMIDES; BIOCATALYSIS; ENZYMES; ESTERS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; OXYGEN ISOTOPES;

EID: 84943350388     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.12.016     Document Type: Review

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