A kinetic isotope effect and isotope exchange study of the nonenzymatic and the equine serum butyrylcholinesterase-catalyzed thioester hydrolysis

Journal of Organic Chemistry

Volumn 78, Issue 23, 2013, Pages 12029-12039

  Robins, Lori I ^a,b   Meisenheimer, Kristen M ^a   Fogle, Emily J ^a   Chaplan, Cory A ^a   Redman, Richard L ^a   Vacca, Joseph T ^a   Tellier, Michelle R ^a   Collins, Brittney R ^a   Duong, Dorothea H ^a   Schulz, Kathrin ^a,c   Marlier, John F ^a  

^a CALIFORNIA POLYTECHNIC STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON BOTHELL   (United States)

^c LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE CONDITIONS; BUTYRYLCHOLINESTERASE; DISPLACEMENT MECHANISMS; ISOTOPE EXCHANGE; KINETIC ISOTOPE EFFECTS; NEUTRAL CONDITIONS; SPECTROSCOPIC METHOD; TETRAHEDRAL INTERMEDIATES;

ALKALINITY; CARRIER MOBILITY; HYDROLYSIS; ISOTOPES; NUCLEOPHILES; REACTION INTERMEDIATES; SOLVENTS; SPECTROSCOPIC ANALYSIS;

CATALYSIS;

CHOLINESTERASE; ISOTOPE; NUCLEOPHILE; THIOESTER;

ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; FRACTIONATION; HYDROLYSIS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOPHILICITY; PH; SYNTHESIS;

BIOCATALYSIS; BUTYRYLCHOLINESTERASE; DEUTERIUM OXIDE; ESTERS; KINETICS; MOLECULAR STRUCTURE; OXYGEN ISOTOPES; SULFHYDRYL COMPOUNDS;

EID: 84890197180     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo402063k     Document Type: Article

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