Ex vivo culture of human fetal gonads: Manipulation of meiosis signalling by retinoic acid treatment disrupts testis development

Human Reproduction

Volumn 30, Issue 10, 2015, Pages 2351-2363

  Jorgensen A ^a   Nielsen, J E ^a   Perlman, S ^a   Lundvall, L ^a   Mitchell, R T ^b,c   Juul, A ^a   Rajpert De Meyts, E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

Author keywords

Germ cell differentiation; Gonad development; Gonadal dysgenesis; Human fetal gonad culture; Meiosis; Retinoic acid

Indexed keywords

CASPASE 3; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 2; KI 67 ANTIGEN; MUELLERIAN INHIBITING FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OCTAMER TRANSCRIPTION FACTOR 4; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR FOXL2; UNCLASSIFIED DRUG; DMRT1 PROTEIN; NR2F2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BRDU ASSAY; CELL COUNTING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; GERM CELL; GESTATIONAL AGE; GONAD; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; MEIOSIS; OOCYTE; PHENOTYPE; SERTOLI CELL; SEX DIFFERENTIATION; SIGNAL TRANSDUCTION; SOMATIC CELL; TESTIS DEVELOPMENT; TISSUE CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EMBRYO CULTURE; EMBRYOLOGY; FETUS; GRANULOSA CELL; METABOLISM; OOGONIUM; ORGAN CULTURE TECHNIQUE; OVARY; PATHOLOGY; PROCEDURES; TESTIS;

ANTI-MULLERIAN HORMONE; APOPTOSIS; CELL PROLIFERATION; COUP TRANSCRIPTION FACTOR II; EMBRYO CULTURE TECHNIQUES; FEMALE; FETUS; GERM CELLS; GRANULOSA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LEYDIG CELLS; MALE; MEIOSIS; OOCYTES; OOGONIA; ORGAN CULTURE TECHNIQUES; OVARY; PHENOTYPE; SEX DIFFERENTIATION; SIGNAL TRANSDUCTION; TESTIS; TRANSCRIPTION FACTORS; TRETINOIN;

EID: 84943311812     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev194     Document Type: Article

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