cAMP-dependent Protein Kinase

Handbook of Cell Signaling: Volume 1-3

Volumn 1-3, Issue , 2003, Pages 471-477

  Taylor, Susan S ^a,b   Radzio Andzelm, Elzbieta ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84943253089     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012124546-7/50560-X     Document Type: Chapter

References (66)

1. D.A. Walsh, J.P. Perkins and E.G. Krebs (1968) An adenosine 3′,5′-mono-phosphate-dependent protein kinase from rabbit skeletal muscle. J. Biol. Chem. 243 3763-3765.
2. S. Shoji, L.H. Ericsson, D.A. Walsh, E.H. Fischer and K. Titani (1983) Amino acid sequence of the catalytic subunit of bovine type II adenosien cyclic 3′,5′-phosphate dependent protein kinase. Biochemistry 22 3702-3709.
3. M.D. Uhler, D.F. Carmichael, D.C. Lee, J.C. Chivia, E.G. Krebs and G.S. McKnight (1986) Isolation of cDNA clones for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA 83 1300-1304.
4. D.R. Knighton, J. Zheng, L.F. Ten Eyck, V.A. Ashford, N.-H. Xuong, S.S. Taylor and J.M. Sowadski (1991) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase. Science 253 407-414.
5. S.S. Taylor, J.A. Buechler and W. Yonemoto (1990) cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59 971-1005.
6. S.H. Francis and J.D. Corbin (1994) Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 56 237-272.
7. J.J. Michel and J.D. Scott (2002) AKAP mediated signal transduction. Annu. Rev. Pharmacol. Toxicol. 42 235-257.
8. D.A. Walsh, K.L. Angelos, S.M. Van Patten, D.B. Glass and L.P. Garetto (1990) B.E. Kemp (Eds) Peptides and Protein Phosphorylation Boca Raton: CRC Press 43-84.
9. W. Wen, J.L. Meinkoth, R.Y. Tsien and S.S. Taylor (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82(3), 463-473.
10. M.O. Showers and R.A. Maurer (1986) A cloned bovine cDNA encodes an alternate form of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 261(35), 16288-16291.
11. S. Beebe, O. Oyen, M. Sandberg, A. Froysa, V. Hansson and T. Jahnsen (1990) Molecular cloning of a tissue-specific protein kinase (C Gamma) from human testis—representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol. Endocrinol. 4 465-475.
12. J.T. San Agustin, C.G. Wilkerson and G.B. Witman (2000) The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative Ca mRNA expressed specifically in spermatogenic cells. Mol. Biol. Cell 11 3031-3044.
13. C. Guthrie, B.S. Skalhegg and G.S. McKnight (1997) Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase. J. Biol. Chem. 272(47), 29560-295605.
14. S.A. Carr, K. Biemann, S. Shoji, D.C. Parmalee and K. Titani (1982) n-Tetradecanoyl in the NH2 terminal blocking group of the catalytic subunit of the cyclic AMP-dependent protein kinase from bovine cardiac muscle. Proc. Natl. Acad. Sci. USA 79(20), 6128-6131.
15. S. Shoji, K. Titani, J.G. Demaille and E.H. Fischer (1979) Sequence of two phosphorylated sites in the catalytic subunit of bovine cardiac, muscle adenosine 3′,5′-monophosphate-dependent protein kinase. J. Biol. Chem. 254 6211-6214.
16. J.A. Adams, M.L. McGlone, R.M. Gibson and S.S. Taylor (1995) Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry 34 2447-2454.
17. W. Yonemoto, M.L. McGlone, B. Grant and S.S. Taylor (1997) Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Eng. 10(8), 915-925.
18. J. Toner-Webb, S.M. van Patten, D.A. Walsh and S.S. Taylor (1992) Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 267(35), 25174-25180.
19. V. Kinzel, N. Konig, R. Pipkorn, D. Bossemeyer and W. Lehmann (2000) The amino terminus of PKA catalytic subunit-a site for introduction of postranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymes. Protein Sci. 11 2269-2277.
20. F. Li, M. Gangal, C. Juliano, E. Gorfain, S.S. Taylor and D.A. Johnson (2002) Evidence for an internal entropy, contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase. J. Mol. Biol. 315(3), 459-469.
21. Ö.Z. Zetterqvist, U. Ragnarsson and L. Engstrom (1990) B.E. Kemp (Eds) Peptides and Protein Phosphorylation Boca Raton: CRC Press 171-187.
22. J.A. Adams (2001) Kinetic and catalytic mechanisms of protein kinases. Chem. Rev. 101(8), 2271-2290.
23. J.A. Adams and S.S. Taylor (1992) The energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry 31(36), 8516-8522.
24. J.A. Adams and S.S. Taylor (1993) Effects of pH on the phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 268(11), 7747-7752.
25. D.R. Knighton, J. Zheng, L.F. Ten Eyck, N.-H. Xuong, S.S. Taylor and J.M. Sowadski (1991) Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253 414-420.
26. J. Zheng, D.R. Knighton, L.F. Ten Eyck, R. Karlsson, N.-H. Xuong, S.S. Taylor and J.M. Sowadski (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32(9), 2154-2161.
27. J. Zheng, D.R. Knighton, N.-H. Xuong, S.S. Taylor, J.M. Sowadski and L.F. Ten Eyck (1993) Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal, open and closed conformations. Protein Sci. 2 1559-1573.
28. S.S. Taylor, D.R. Knighton, J. Zheng, L.F. Ten Eyck and J.M. Sowadski (1992) Structural framework for the protein kinase family. Annu. Rev. Cell Biol. 8 429-462.
29. M. Veron, E. Radzio-Andzelm, I. Tsigelny, L.F. Ten Eyck and S.S. Taylor (1993) A conserved helix motif complements the protein kinase core. Proc. Natl. Acad. Sci. USA 90 10618-10622.
30. M. Batkin, I. Schvartz and S. Shaltiel (2000) Snapping of the carboxyl terminal tail of the catalytic subunit of PKA onto its core: characterization of the sites by mutagenesis. Biochemistry 39(18), 5366-5373.
31. N. Narayana, S. Cox, N.-H. Xuong, L.F. Ten Eyck and S.S. Taylor (1997) A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. Structure 5 921-935.
32. S.K. Hanks and T. Hunter (1995) Protein kinases 6. The eukaryotic kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 8 576-596.
33. M.J. Zoller and S.S. Taylor (1979) Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5′-adenosine: Identification of a modified lysine residue. J. Biol. Chem. 254 8363-8368.
34. J.A. Buechler and S.S. Taylor (1988) Identification of Asp 184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase. Biochemistry 27 7356-7361.
35. S.S. Taylor, D.R. Knighton, J. Zheng, J.M. Sowadski, C.S. Gibbs and M.J. Zoller (1993) A template for the protein kinase family. Trends Biochem. Sci. 18(3), 84-89.
36. D.A. Johnson, P. Akamine, E. Radzio-Andzelm, Madhusudan and S.S. Taylor (2001) Dynamics of cAMP-dependent protein kinase. Chem. Rev. 101(8), 2243-2270.
37. D. Bossemeyer, R.A. Engh, V. Kinzel, H. Ponstingl and R. Huber (1993) Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 structure of the complex with Mn2+ adenyl imidodiphosphate and inhibitor peptide PKI(5–24). EMBO J. 12(3), 849-859.
38. Madhusudan, P. Akamine, N.-H. Xuong and S.S. Taylor (2002) Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat. Struct. Biol. 9(4), 273-277.
39. R.T. Aimes, W. Hemmer and S.S. Taylor (2000) Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors. Biochemistry 39(28), 8325-8332.
40. L. Johnson, M. Noble and D. Owen (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85(2), 149-158.
41. J. Zhou and J.A. Adams (1997) Is there a catalytic base in the active site of cAMP-dependent protein kinase? Biochemistry 10 2977-2984.
42. X. Cheng, Y. Ma, M. Moore, B.A. Hemmings and S.S. Taylor (1998) Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc. Natl. Acad. Sci. 95 9849-9854.
43. R.D. Cauthron, K.B. Carter, S. Liauw and R.A. Steinberg (1998) Physiological phosphorylation of protein kinase A at Thr-197 is by a protein kinase A kinase. Mol. Cell Biol. 18 1416-1423.
44. J.A. Hauer, P. Barthe, S.S. Taylor, J. Parello and A. Padille (1999) Two well defined motifs in the cAMP-dependent protein kinase inhibitior (PKIa) correlate with inhibitory and nuclear export function. Protein Sci. 8 545-553.
45. F. Li, M. Gangal, J.M. Jones, J. Deich, K.E. Lovett, S.S. Taylor and D.A. Johnson (2000) Consequences of cAMP and catalyticsubnit binding on the flexibility of the A-kinase regulatory subunit. Biochemistry 39(50), 15626-15632.
46. C.A. Stratakis, W.R. Miller, E. Severin, K.V. Chin, J. Bertherat, P.S. Amieux, C. Eng, G.M. Kammer, J.E. Dumont, G. Tortora, M.A. Beaven, T.T. Puck, S.M. Jan De Beur, L.S. Weinstein and Y.S. Cho-Chung (2002) Protein-kinase A and human disease: the core of cAMP-dependent signaling in health and disease. Horm. Metab Res. 34(4), 169-175.
47. D.E. Cummings, E.P. Brandon, J.V. Planas, K. Motamed, R.L. Idzerda and G.S. McKnight (1996) Genetically lean mice result from targeted disruption of the RII ebeta subunit of protein kinase A [see comments]. Nature 382(6592), 622-626.
48. P.S. Amieux, D.E. Cummings, K. Motamed, E.P. Brandon, L.A. Wailes, K. Le, R.L. Idzerda and G.S. McKnight (1997) Compensatory regulation of RIa protein levels in protein kinase A mutant mice. J. Biol. Chem. 272 3993-3998.
49. T.E. Thiele, B. Willis, J. Stadler, J.G. Reynolds, I.L. Bernstein and G.S. McKnight (2000) High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice. J. Neurosci. 20 1-6.
50. L.S. Kirschner, J.A. Carney, D.P. Svetlana, S.E. Taymans, C. Giatzkis, Y.S. Cho, Y.S. Cho-Chung and C.A. Stratakis (2000) Mutations of the gene encoding the protein kinase A type I-a regulatory subunit in patients with Carney, complex. Nature Genet. 26 89.
51. F.W. Herberg, M.L. Doley, S. Cox and S.S. Taylor (1999) Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry 38 6352-6360.
52. G.G. Cadd, M.D. Uhler and G.S. McKnight (1990) Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides. J. Biol. Chem. 265(32), 19502-19506.
53. S.F. Steinberg and L.L. Brunton (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu. Rev. Pharmacol. Toxicol. 41 751-773.
54. J. Bubis, J.J. Neitzel, L.D. Saraswat and S.S. Taylor (1998) A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. J. Biol. Chem. 263 9668-9673.
55. L.J. Huang and S.S. Taylor (1998) Dissecting cAMP binding domain A in the RIa subunit of cAMP-dependent protein kinase: distinct subsites for recognition of cAMP and the catalytic subunit. J. Biol. Chem. 273 26739-26746.
56. D. Øgreid and S.O. Døskeland (1983) Cyclic nucleotides modulate the release of [^3H]adenosine Cyclic 3′,5′-phosphate bound to the regulatory moiety of protein kinase I by the catalytic subunit of the kinase. Biochemistry 22 1686-1696.
57. J.M. Canaves and S.S. Taylor (2002) Classification and phylogenetic analysis of cAMP-dependent protein kinase regulatory subunit family. J. Mol. Evol. 54(1), 17-29.
58. W. Bonigk, et al. (1999) The native rat olfactory cyclic nucleotidegated channel is composed of three distinct subunits. J. Neurosci. 19 5332-5347.
59. J. de Rooij, F.J.T. Zwawrtkruis, M.H.G. Verheijen, R.H. Cool, S.M.B. Nijman, A. Wittinghofer and J.L. Bos (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396(6710), 474-477.
60. G. Anand, C. Hughes, J. Jones, S. Taylor and E. Komives (2002) Amide H/2H exchange reveals communication between the cAMP- and catalytic subunit-binding sites in the RIα subunit of protein kinase A. J. Mol. Biol. In press
61. Y. Su, W.R.G. Dostmann, F.W. Herberg, K. Durick, N.-H. Xuong, L.F. Ten Eyck, S.S. Taylor and K.I. Varughese (1995) Regulatory (RIa) subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science 269 807-819.
62. T.C. Diller, N.-H. Xuong and S.S. Taylor (2000) Type IIB regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization. Protein Express. Purific. 20 357-364.
63. P. Banky, M.G. Newlon, M. Roy, S. Garrod, S.S. Taylor and P.A. Jennings (2000) Isoform-specific differences between the type Ia and IIa cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J. Biol. Chem. 275 35146-35152.
64. M.G. Newlon, M. Roy, D. Morikis, D.W. Carr, R. Westphal, J.D. Scott and P.A. Jennings (2001) A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J. 7 1651-1662.
65. M. Gangal, F. Li, J.M. Jones, J. Deich, K. Lovett, S.S. Taylor and D.A. Johnson (2000) Consequences of cAMP and catalytic subunit binding on the flexibility of the A-kinase of the regulatory subunit. Biochemistry 39(50), 15626-15632.
66. C.S. Tung, D.A. Walsh and J. Trewhella (2002) A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase. J. Biol. Chem. 277(14), 12423-12431.