CXCL16 Haplotypes in Patients with Human Carotid Atherosclerosis: Preliminary Results

Journal of Atherosclerosis and Thrombosis

Volumn 22, Issue 1, 2015, Pages 10-20

  Zivković, Maja ^a   Djurić, Tamara ^a   Stojković, Ljiljana ^a   Jovanović, Ivan ^a   Končar, Igor ^b,c   Davidović, Lazar ^b,c   Veljković, Nevena ^a   Alavantić, Dragan ^a   Stanković, Aleksandra ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Carotid plaque; CXCL16; CXCR6; Gene expression; Haplotype

Indexed keywords

CHEMOKINE RECEPTOR CXCR6; CXCL16 CHEMOKINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; ALPHA CHEMOKINE; CHEMOKINE RECEPTOR; CXCL16 PROTEIN, HUMAN; CXCR6 PROTEIN, HUMAN; MESSENGER RNA; SCAVENGER RECEPTOR; VIRUS RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; ATHEROSCLEROSIS; CAROTID ATHEROSCLEROSIS; CAROTID ENDARTERECTOMY; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE INTERACTION; GENETIC ANALYSIS; HAPLOTYPE; HUMAN; HUMAN TISSUE; INTERNAL CAROTID ARTERY; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SPECTROPHOTOMETRY; ULTRASOUND; ULTRASOUND TRANSDUCER; BLOOD; CAROTID ARTERY DISEASE; CASE CONTROL STUDY; COMPARATIVE STUDY; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; CHEMOKINES, CXC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CHEMOKINE; RECEPTORS, SCAVENGER; RECEPTORS, VIRUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84943240571     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.24299     Document Type: Article

References (29)

1. Hansson GK, Libby P: The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol, 2006; 6: 508-519
2. Shimaoka T, Kume N, Minami M, Hayashida K, Kataoka H, Kita T, Yonehara S: Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SRPSOX, on macrophages. J Biol Chem, 2000; 275: 40663-40666
3. Kang S, Yang C, Luo R: LysoPtdOH enhances CXCL16 production stimulated by LPS from macrophages and regulates T cell migration. Lipids, 2008; 43: 1075-1083
4. Barlic J, Zhu W, Murphy PM: Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion. J Immunol, 2009; 182: 7928-7936
5. Tabata S, Kadowaki N, Kitawaki T, Shimaoka T, YoneharaS, Yoshie O, Uchiyama T: Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4+ T cells. J Leukoc Biol, 2005; 77: 777-786
6. van der Voort R, Verweij V, de Witte TM, Lasonder E, Adema GJ, Dolstra H: An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells. J Leukoc Biol, 2010; 87: 1029-1039
7. Hofnagel O, Luechtenborg B, Plenz G, Robenek H: Expression of the novel scavenger receptor SR-PSOX in cultured aortic smooth muscle cells and umbilical endothelial cells. Arterioscler Thromb Vasc Biol, 2002; 22: 710-711
8. Wågsäter D, Olofsson PS, Norgren L, Stenberg B, Sirsjö A: The chemokine and scavenger receptor CXCL16/SRPSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma. Biochem Biophys Res Commun, 2004; 325: 1187-1193
9. Wilbanks A, Zondlo SC, Murphy K, Mak S, Soler D, Langdon P, Andrew DP, Wu L, Briskin M.: Expression cloning of the STRL33/BONZO/TYMSTR ligand reveals elements of CC, CXC, and CX3C chemokines. J Immunol, 2001; 166: 5145-5154
10. Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW: A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J Immunol, 2004; 172: 3678-3685
11. Minami M, Kume N, Shimaoka T, Kataoka H, Hayashida K, Akiyama Y, Nagata I, Ando K, Nobuyoshi M, Hanyuu M, Komeda M, Yonehara S, Kita T: Expression of SRPSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol, 2001; 21: 1796-1800
12. Wuttge DM, Zhou X, Sheikine Y, Wågsäter D, Stemme V, Hedin U, Stemme S, Hansson GK, Sirsjö A: CXCL16/ SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions. Arterioscler Thromb Vasc Biol, 2004; 24: 750-755
13. Galkina E, Harry BL, Ludwig A, Liehn EA, Sanders JM, Bruce Bruce A, Weber C, Ley K: CXCR6 promotes atherosclerosis by supporting T-cell homing, interferongamma production, and macrophage accumulation in the aortic wall. Circulation, 2007; 116: 1801-1811
14. Aslanian AM, Charo I: Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation, 2006; 114: 583-590
15. Sheikine Y, Bang CS, Nilsson L, Samnegård A, Hamsten A, Jonasson L, Eriksson P, Sirsjö A: Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease. Atherosclerosis, 2006; 188: 462-466
16. Lundberg GA, Kellin A, Samnegård A, Lundman P, Tornvall P, Dimmeler S, Zeiher AM, Hamsten A, Hansson GK, Eriksson P: Severity of coronary artery stenosis is associated with a polymorphism in the CXCL16/SRPSOX gene. J Intern Med, 2005; 257: 415-422
17. Huang M, Han Y, Zhang X, Pei F, Deng J, Kang J, Yan C: An intron polymorphism in the CXCL16 gene is associated with increased risk of coronary artery disease in Chinese Han population: a large angiography-based study. Atherosclerosis, 2009; 210: 160-165
18. Petit SJ, Wise EL, Chambers JC, Sehmi J, Chayen NE, Kooner JS, Pease JE: The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease. Arterioscler Thromb Vasc Biol, 2011; 31: 914-920
19. North American Symptomatic Carotid Endarterectomy Trial Collaborators: Beneficial effect of carotid endarterectomy in symptomatic patients with highgrade carotid stenosis. N Engl J Med, 1991; 325: 445-453
20. Gray-Weale AC, Graham JC, Burnett JR, Byrne K, Lusby RJ: Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg (Torino), 1988; 29: 676-68
21. Livak KJ, Schmittgen TD.: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 2001; 25: 402-408
22. Veljkovic V, Veljkovic N, Esté JA, Hüther A, Dietrich U: Application of the EIIP/ISM bioinformatics concept in development of new drugs. Curr Med Chem, 2007; 14: 441-453
23. Tregouet DA, and Garelle V: A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies. Bioinformatics, 2007; 23: 1038-1039
24. Tregouet DA, Escolano S, Tiret L, Mallet A, Golmard JL: A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm. Ann Hum Genet, 2004; 68: 165-177
25. Pfaffl MW, Horgan GW, Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res, 2002; 30(9): e36
26. Menashe I, Rosenberg PS, Chen BE: PGA, power calculator for case-control genetic association analyses. BMC Genet, 2008; 9: 36
27. Lehrke M, Millington SC, Lefterova M, Cumaranatunge RG, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP: CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol, 2007; 49: 442-449
28. Shimaoka T, Nakayama T, Hieshima K, Kume N, Fukumoto N, Minami M, Hayashida K, Kita T, Yoshie O, Yonehara S: Chemokines generally exhibit scavenger receptor activity through their receptor-binding domain. J Biol Chem, 2004; 279: 26807-26810
29. Chandrasekar B, Bysani S, Mummidi S: CXCL16 signals via Gi, PI3 kinase, Akt, Ikappa B kinase and nuclear factor- kappa B, and induces cell-cell adhesion and aortic smooth muscle cell proliferation. J Biol Chem, 2004; 279: 3188-3196