Is IVF-served two different ways-more cost-effective than IUI with controlled ovarian hyperstimulation?

Human Reproduction

Volumn 30, Issue 10, 2015, Pages 2331-2339

  Tjon Kon Fat, R I ^a   Bensdorp, A J ^a   Bossuyt, P M M ^a   Koks, C ^b   Oosterhuis, G J E ^c   Hoek, A ^d   Hompes, P ^e   Broekmans, F J ^f   Verhoeve, H R ^g   De Bruin, J P ^h   Van Golde, R ⁱ   Repping, S ^a   Cohlen, B J ^j   Lambers, M D A ^k   Van Bommel, P F ^l   Slappendel, E ^m   Perquin, D ⁿ   Smeenk, J ^o   Pelinck, M J ^p   Gianotten, J ^q   Hoozemans, D A ^r   Maas, J W M ^b   Groen, H ^d   Eijkemans, M J C ^f   Van Der Veen, F ^a   Mol, B W J ^s   Van Wely, M ^a   more..

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MÁXIMA MEDICAL CENTER   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^h JEROEN BOSCH HOSPITAL   (Netherlands)

ⁱ MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^j ISALA HOSPITAL   (Netherlands)

^k ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^l AMPHIA HOSPITAL   (Netherlands)

^m CATHARINA HOSPITAL   (Netherlands)

ⁿ MEDICAL CENTER LEEUWARDEN   (Netherlands)

^o CPRLab   (Netherlands)

^p Scheper Ziekenhuis   (Netherlands)

^q Infection and Immunology   (Netherlands)

^r MEDISCH SPECTRUM TWENTE   (Netherlands)

^s UNIVERSITY OF ADELAIDE   (Australia)

more..

Author keywords

Cost effectiveness; In vitro fertilization; Intrauterine insemination; Modified natural cycle; Single embryo transfer

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; GONADORELIN ANTAGONIST;

ARTICLE; COMPARATIVE STUDY; CONCEPTION; CONTROLLED OVARIAN HYPERSTIMULATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DOWN REGULATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HEALTH CARE COST; HUMAN; INTRAUTERINE INSEMINATION; MALE; MILD MALE SUBFERTILITY; MULTICENTER STUDY; MULTIPLE PREGNANCY; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; PREGNANCY RATE; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; SUBFERTILITY; TRANSVAGINAL ECHOGRAPHY; UNEXPLAINED MALE SUBFERTILITY; ADULT; ARTIFICIAL INSEMINATION; COST BENEFIT ANALYSIS; CRYOPRESERVATION; ECONOMICS; FERTILIZATION; INFERTILITY, MALE; NETHERLANDS; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PROCEDURES; SINGLE EMBRYO TRANSFER; STATISTICAL MODEL;

ADULT; COST-BENEFIT ANALYSIS; CRYOPRESERVATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, MALE; INSEMINATION, ARTIFICIAL; MALE; MODELS, ECONOMIC; NETHERLANDS; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; PROGNOSIS; SINGLE EMBRYO TRANSFER;

EID: 84943240485     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev193     Document Type: Article

References (36)

1. Baart EB, Martini E, Eijkemans MJ, Van Opstal D, Beckers GM, Verhoeff A, Macklon NS, Fauser BCJM. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 2007;22:980-988.
2. Bensdorp AJ, Slappendel E, Koks C, Oosterhuis J, Hoek A, Hompes P, Broekmans F, Verhoeve H, de Bruin JP, van Weert JM et al. The INeS study: prevention of multiple pregnancies: a randomised controlled trial comparing IUI COH versus IVF e SET versus MNC IVF in couples with unexplained or mild male subfertility. BMC Womens Health 2009;9:35.
3. Bensdorp AJ, Tjon-Kon-Fat RI, Bossuyt PMM, Koks CAM, Oosterhuis GJE, Hoek A, Hompes PGA, Broekmans FJM, Verhoeve HR, de Bruin JP et al. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine inse. BMJ 2015;350:g7771.
4. Berwick DM, Hackbarth AD. Eliminatingwaste in US health care. JAMA 2012; 307:1513-1516.
5. Boivin J, Griffiths E, Venetis CA. Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies. BMJ 2011;342:d223.
6. Braakhekke M, Kamphuis EI, Dancet EA, Mol F, van der Veen F, Mol BW. Ongoing pregnancy qualifies best as the primary outcome measure of choice in trials in reproductive medicine: an opinion paper. Fertil Steril 2014;101:1203-1204.
7. Brandes M, Hamilton CJCM, Bergevoet KAYJ, de Bruin JP, Nelen WLDM, Kremer JAM. Origin of multiple pregnancies in a subfertile population. Acta Obstet Gynecol Scand 2010;89:1149-1154.
8. ChambersGM, Sullivan EA, Shanahan M, HoMT, Priester K, ChapmanMG. Is in vitro fertilisation more effective than stimulated intrauterine insemination as a first-line therapy for subfertility? A cohort analysis. Aust N Z J Obstet Gynaecol 2010;50:280-288.
9. Chambers GM, Adamson GD, Eijkemans MJC. Acceptable cost for the patient and society. Fertil Steril 2013;100:319-327.
10. Clarke JF, van Rumste MME, Farquhar CM, Johnson NP, Mol BWJ, Herbison P. Measuring outcomes in fertility trials: can we rely on clinical pregnancy rates? Fertil Steril 2010;94:1647-1651.
11. Devroey P, Bourgain C, Macklon NS, Fauser BCJM. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84-90.
12. Groen H, Tonch N, Simons AHM, van derVeen F, Hoek A, Land JA. Modified natural cycle versus controlled ovarian hyperstimulation IVF: a cost-effectiveness evaluation of three simulated treatment scenarios. Hum Reprod 2013;28:3236-3246.
13. Hunault CC, Habbema JDF, Eijkemans MJC, Collins JA, Evers JLH, te Velde ER. Two new prediction rules for spontaneous pregnancy leading to live birth among subfertile couples, based on the synthesis of three previous models. Hum Reprod 2004;19:2019-2026.
14. IBM SPSS Statistics for Windows, version 22. 0. Armonk, NY, USA: IBM Corp, 2011.
15. Kamphuis E, Bhattacharya S, van der Veen F, MolBW, Templeton A. Arewe overusing IVF? BMJ 2014;252:1-5.
16. Lukassen HGM, Schönbeck Y, Adang EMM, Braat DDM, Zielhuis GA, Kremer JAM. Cost analysis of singleton versus twin pregnancies after in vitro fertilization. Fertil Steril 2004;81:1240-1246.
17. Nargund G, Chian RC. ISMAAR: leading the global agenda for a more physiological, patient-centred, accessible and safer approaches in ART. J Assist Reprod Genet 2013;30:155-156.
18. National Collaborating Centre for Women's and Children's Health. Fertility: assessment and treatment for people with fertility problems. London, UK: National Collaborating Centre for Women's and Children's Health, 2013. www. nice. org. uk/guidance/cg156 (5 March 2015, date last accessed).
19. Neumann PJ, Johannesson M. The willingness to pay for in vitro fertilization: a pilot study using contingent valuation. Med Care 1994;32:686-699.
20. OECD. Health at a Glance 2013: OECD indicators. Paris, France: OECD Publishing, 2013. http://dx. doi. org/10. 1787/health-glance-2013-en (5 March 2015, date last accessed).
21. Pelinck MJ, Vogel NEA, Arts EGJM, Simons AHM, Heineman MJ, Hoek A. Cumulative pregnancy rates after a maximum of nine cycles of modified natural cycle IVF and analysis of patient drop-out: a cohort study. Hum Reprod 2007;22:2463-2470.
22. Pharmacotherapeutic Compass. Diemen. The Netherlands: College voor zorgverzekeringen, 2013. www. fk. cvz. nl (14 January 2013, date last accessed).
23. Puissant F, VanRysselberge M, BarlowP, Deweze J, Leroy F. Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod 1987;2:705-708.
24. Reindollar RH, ReganMM, Neumann PJ, Levine B-S, Thornton KL, AlperMM, Goldman MB. Arandomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial. Fertil Steril 2010;94:888-899.
25. Reinhardt UE, Hussey PS, Anderson GF. U. S. health care spending in an international context. Health Aff 2004;23:10-25.
26. Romundstad LB, Opdahl S, Pinborg A. Which treatment option for couples with unexplained or mild male subfertility? BMJ 2015;350:g7843.
27. Statistics Netherlands: Statline Consumers Pricing Index, 2014. Den Haag/Heerlen, The Netherlands: Statistics Netherlands. www. statline. cbs. nl (5 March 2015, date last accessed).
28. Steures P, van der Steeg JW, Hompes PGA, Bossuyt PMM, Habbema JDF, Eijkemans MJC, Koks CAM, Boudrez P, van der Veen F, Mol BWJ. The additional value of ovarian hyperstimulation in intrauterine insemination for couples with an abnormal postcoital test and a poor prognosis: a randomized clinical trial. Fertil Steril 2007;88:1618-1624.
29. The Practice Committee of the American Society for Reproductive Medicine. Effectiveness and treatment for unexplained infertility. Fertil Steril 2006; 86:S111-S114.
30. Tilburt JC, Wynia MK, Sheeler RD, Thorsteinsdottir B, JamesKM, Egginton JS, Liebow M, Hurst S, Danis M, Goold SD. Views of US physicians about controlling health care costs. JAMA 2013;310:380-388.
31. Van Der Steeg JW, Steures P, Eijkemans MJC, Habbema JDF, Hompes PGA, Broekmans FJ, Van Dessel HJHM, Bossuyt PMM, Van Der Veen F et al. Pregnancy is predictable : a large-scale prospective external validation of the prediction of spontaneous pregnancy in subfertile couples. Hum Reprod 2006;1316:1-7.
32. van Rumste MME, Custers IM, van der Veen F, van Wely M, Evers JLH, Mol BWJ. The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Hum Reprod Update 2008;14:563-570.
33. van Rumste MME, Custers IM, van Wely M, Koks CA, van Weering HGI, Beckers NGM, Scheffer GJ, Broekmans FJM, Hompes PGA, Mochtar MH et al. IVF with planned single-embryo transfer versus IUI with ovarian stimulation in couples with unexplained subfertility: an economic analysis. Reprod Biomed Online 2014;28:336-342.
34. VerbergMFG, MacklonNS, Nargund G, FrydmanR, Devroey P, Broekmans FJ, Fauser BCJM. Mild ovarian stimulation for IVF. Hum Reprod Update 2009; 15:13-29.
35. Visser GHA, Eilers PHC, Elferink-Stinkens PM, Merkus HMWM, Wit JM. New Dutch reference curves for birthweight by gestational age. Early Hum Dev 2009;85:737-744.
36. Wong KM, Mastenbroek S, Repping S. Cryopreservation of human embryos and its contribution to in vitro fertilization success rates. Fertil Steril 2014; 102:19-26.