Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells

Cell Reports

Volumn 13, Issue 1, 2015, Pages 52-60

  Lee, Bum Kyu ^a   Shen, Wenwen ^a   Lee, Jiwoon ^a   Rhee, Catherine ^a   Chung, Haewon ^a   Kim, Kun Yong ^b   Park, In Hyun ^b   Kim, Jonghwan ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; HISTONE DEACETYLASE 1; OCTAMER TRANSCRIPTION FACTOR 4; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR TGIF1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACTIVIN; HDAC1 PROTEIN, MOUSE; HDAC2 PROTEIN, MOUSE; HISTONE DEACETYLASE 2; HOMEODOMAIN PROTEIN; NANOG PROTEIN, MOUSE; POU5F1 PROTEIN, MOUSE; REPRESSOR PROTEIN; SOX2 PROTEIN, MOUSE; TGIF PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GENE TARGETING; MESODERM; MOUSE; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TARGETING; UPREGULATION; ANIMAL; CYTOLOGY; ECTODERM; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; MAMMALIAN EMBRYO; METABOLISM; MOUSE EMBRYONIC STEM CELL; SIGNAL TRANSDUCTION;

ACTIVINS; ANIMALS; CELL DIFFERENTIATION; ECTODERM; EMBRYO, MAMMALIAN; ENDODERM; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HOMEODOMAIN PROTEINS; MESODERM; MICE; MOUSE EMBRYONIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84943233655     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.08.067     Document Type: Article

References (30)

1. Bartholin L., Powers S.E., Melhuish T.A., Lasse S., Weinstein M., Wotton D. TGIF inhibits retinoid signaling. Mol. Cell. Biol. 2006, 26:990-1001.
2. Bartholin L., Melhuish T.A., Powers S.E., Goddard-Léon S., Treilleux I., Sutherland A.E., Wotton D. Maternal Tgif is required for vascularization of the embryonic placenta. Dev. Biol. 2008, 319:285-297.
3. Beck S., Lee B.K., Rhee C., Song J., Woo A.J., Kim J. CpG island-mediated global gene regulatory modes in mouse embryonic stem cells. Nat. Commun. 2014, 5:5490.
4. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., Fry B., Meissner A., Wernig M., Plath K., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125:315-326.
5. Cole M.F., Johnstone S.E., Newman J.J., Kagey M.H., Young R.A. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Genes Dev. 2008, 22:746-755.
6. Fei T., Zhu S., Xia K., Zhang J., Li Z., Han J.D., Chen Y.G. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010, 20:1306-1318.
7. Fidalgo M., Shekar P.C., Ang Y.S., Fujiwara Y., Orkin S.H., Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells 2011, 29:1705-1716.
8. Gripp K.W., Wotton D., Edwards M.C., Roessler E., Ades L., Meinecke P., Richieri-Costa A., Zackai E.H., Massagué J., Muenke M., Elledge S.J. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat. Genet. 2000, 25:205-208.
9. Jaenisch R., Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008, 132:567-582.
10. James D., Levine A.J., Besser D., Hemmati-Brivanlou A. TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005, 132:1273-1282.
11. Kelly V.R., Xu B., Kuick R., Koenig R.J., Hammer G.D. Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Mol. Endocrinol. 2010, 24:2281-2291.
12. Kieffer-Kwon K.R., Tang Z., Mathe E., Qian J., Sung M.H., Li G., Resch W., Baek S., Pruett N., Grøntved L., et al. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell 2013, 155:1507-1520.
13. Kim J., Chu J., Shen X., Wang J., Orkin S.H. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008, 132:1049-1061.
14. Kim J., Woo A.J., Chu J., Snow J.W., Fujiwara Y., Kim C.G., Cantor A.B., Orkin S.H. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010, 143:313-324.
15. Kopp J.L., Ormsbee B.D., Desler M., Rizzino A. Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells. Stem Cells 2008, 26:903-911.
16. Liu F. PCTA: a new player in TGF-beta signaling. Sci. Signal. 2008, 1:pe49.
17. Mar L., Hoodless P.A. Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. Mol. Cell. Biol. 2006, 26:4302-4310.
18. Marks H., Kalkan T., Menafra R., Denissov S., Jones K., Hofemeister H., Nichols J., Kranz A., Stewart A.F., Smith A., Stunnenberg H.G. The transcriptional and epigenomic foundations of ground state pluripotency. Cell 2012, 149:590-604.
19. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., Okita K., Mochiduki Y., Takizawa N., Yamanaka S. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 2008, 26:101-106.
20. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
21. Pera M.F., Tam P.P. Extrinsic regulation of pluripotent stem cells. Nature 2010, 465:713-720.
22. Powers S.E., Taniguchi K., Yen W., Melhuish T.A., Shen J., Walsh C.A., Sutherland A.E., Wotton D. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development 2010, 137:249-259.
23. Shen J., Walsh C.A. Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol. Cell. Biol. 2005, 25:3639-3647.
24. Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., Paulovich A., Pomeroy S.L., Golub T.R., Lander E.S., Mesirov J.P. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 2005, 102:15545-15550.
25. Sun C., Nakatake Y., Akagi T., Ura H., Matsuda T., Nishiyama A., Koide H., Ko M.S., Niwa H., Yokota T. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Mol. Cell. Biol. 2009, 29:4574-4583.
26. Wang J., Rao S., Chu J., Shen X., Levasseur D.N., Theunissen T.W., Orkin S.H. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006, 444:364-368.
27. Wang Z.X., Teh C.H., Chan C.M., Chu C., Rossbach M., Kunarso G., Allapitchay T.B., Wong K.Y., Stanton L.W. The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes. Stem Cells 2008, 26:2791-2799.
28. Wotton D., Lo R.S., Lee S., Massagué J. A Smad transcriptional corepressor. Cell 1999, 97:29-39.
29. Wotton D., Lo R.S., Swaby L.A., Massagué J. Multiple modes of repression by the Smad transcriptional corepressor TGIF. J. Biol. Chem. 1999, 274:37105-37110.
30. Young R.A. Control of the embryonic stem cell state. Cell 2011, 144:940-954.